Paradoxical Autonomic Response to Mental Tasks in Autism
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Autonomic responses to mental tasks requiring sustained attention were examined in individuals with autism and age- and ability-matched controls. Cardiac autonomic function (CAF) was evaluated based on heart rate variability. While the control group showed a significant decrease in the parasympathetic function during mental tasks, the autistic group showed no significant changes in CAF. When examined individually, parasympathetic function was suppressed in all subjects in the control group. On the other hand, parasympathetic function was activated in half of the autistic subjects. The paradoxical autonomic response suggests that some autistic subjects were more stressed under ‘resting’ conditions than while performing mechanical or repetitive mental tasks. The results seem to support autonomic hyperarousal in some people with autism.
American-Psychiatric-Association. (1994). DSM-IV: Diagnostic and Statistical Manual of Mental Disorders. (4th ed.). Washington, D.C.: American Psychiatric Association.
Anderson, L. T., Campbell, M., Grega, D. M., Perry, R., Small, A. M., & Green, W. H. (1984). Haloperidol in the treatment of infantile autism: Effects on learning and behavioral symptoms. American Journal of Psychiatry, 141, 1195–1202.PubMed
Angus, Z. (1970). Autonomic and cognitive functions in childhood psychosis. Bulletin of British Psychology Society, 23, 228–229.
Anthony, J. (1958). An experimental approach to the psychopathology of childhood: Autism. British Journal of Medical Psychology, 31, 211–225.PubMed
Bartak, L., Rutter, M., & Cox, A. (1975). A comparative study of infantile autism and specific developmental receptive language disorder: I. The children. British Journal of Psychiatry, 126, 127–145.
Bernal, M. E., & Miller, W. H. (1971). Electrodermal and cardiac responses of schizophrenic children to sensory stimuli. Psychophysiology, 7, 155–168.
Cohen, J. D., & Johnson, W. T. (1977). Cardiovascular correlates of attention in normal and psychiatrically disturbed children. Archives of General Psychiatry, 34, 561–567.PubMed
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995). Contributions of anterior cingulate cortex to behaviour. Brain, 118, 279–306.PubMed
Ernst, M., Magee, H. J., Gonzalez, N. M., Locascio, J. J., Rosenberg, C. R., & Campbell, M. (1992). Pimozide in autistic children. Psychopharmacological Bulletin, 28, 187–191.
Fein, D., Pennington, B., Markowitz, P., Braverman, M., & Waterhouse, L. (1986). Toward a neuropsychological model of infantile autism: Are the social deficits primary? Journal of the American Academy of Child Psychiatry, 25, 198–212.PubMed
Fein, D., Pennington, B., & Waterhouse, L. (1987). Implications of social deficits in autism for neurological dysfunction. In E. Schopler & G. B. Mesibov (Eds.), Neurobiological Issues in Autism, (pp. 127–144). New York: Plenum Press.
Fein, D., Skoff, B., & Mirsky, A. F. (1981). Clinical correlates of brainstem dysfunction in autistic children. Journal of Autism and Developmental Disorders, 11, 303–315.PubMed
Findling, R. L., Maxwell, K., & Wiznitzer, M. (1997). An open clinical trial of risperidone monotherapy in young children with autistic disorder. Psychopharmacological Bulletin, 33, 155–159.
Fineman, K. R. (1968). Visual-color reinforcement in establishment of speech by an autistic child. Perceptual and Motor Skills, 26, 761–762.PubMed
Goldfarb, W. (1956). Receptor preferences in schizophrenic children. Archives of Neurology and Psychiatry, 76, 643–652.
Graveling, R. A., & Brooke, J. D. (1978). Hormonal and cardiac response of autistic children to changes in environmental stimulation. Journal of Autism and Childhood Schizophrenia, 8, 441–455.PubMed
Hayano, J., Sakakibara, Y., Yamada, A., Yamada, M., Mukai, S., Fujinami, T., Yokoyama, K., Watanabe, Y., & Takata, K. (1991). Accuracy of assessment of cardiac vagal tone by heart rate variability in normal subjects. American Journal of Cardiology, 67, l99–204.CrossRef
Haznedar, M. M., Buchsbaum, M. S., Metzger, M., Solimando, A., Spiegel-Cohen, J., & Hollander, E. (1997). Anterior cingulate gyrus volume and glucose metabolism in autistic disorder. American Journal of Psychiatry, 154, 1047–1050.PubMed
Haznedar, M. M., Buchsbaum, M. S., Wei, T. C., Hof, P. R., Cartwright, C., Bienstock, C. A., & Hollander, E. (2000). Limbic circuitry in patients with autism spectrum disorders studied with positron emission tomography and magnetic resonance imaging. American Journal of Psychiatry, 157, 1994–2001.PubMed
Hermelin, B., & O'Connor, N. (1968). Measures of the occipital alpha rhythm in normal, subnormal and autistic children. British Journal of Psychiatry, 114, 603–610.
Hutt, C., Forrest, S. J., & Richer, J. (1975). Cardiac arrhythmia and behaviour in autistic children. Acta Psychiatrica Scandinavica, 51, 361–372.PubMed
Hutt, C., Hutt, S. J., Lee, D., & Ounsted, C. (1964). Arousal and childhood autism. Nature, 204, 908–909.PubMed
Hyndman, B. W., & Gregory, J. R. (1975). Spectral analysis of sinus arrhythmia during mental loading. Ergonomics, 18, 255–270.PubMed
Kanner, L. (1943). Autistic disturbances of affective contact. Nervous Child, 2, 217–250.
Kodama, H., Shinagawa, F., & Motegi, M. (1982). Japanese Wechsler Intelligence Scale for Children-Revised. Tokyo: Nihon-Bunka-Kagaku-sha.
Kootz, J. P., & Cohen, J. D. (1981). Modulation of sensory intake in autistic children: Cardiovascular and behavioral indices. Journal of American Academy of Child Psychiatry, 20, 692–701.
Kootz, J. P., Marinelli, B., & Cohen, D. J. (1982). Modulation of response to environmental stimulation in autistic children. Journal of Autism and Developmental Disorders, 12, 185–193.PubMed
Lake, C. R., Ziegler, M. G., & Murphy, D. L. (1977). Increased norepinephrine levels and decreased dopamine-*b-hydroxylase activity in primary autism. Archives of General Psychiatry, 34, 553–556.PubMed
Lucini, D., Covacci, G., Milani, R., Mela, G. S., Malliani, A., & Pagani, M. (1997). A controlled study of the effects of mental relaxation on autonomic excitatory responses in healthy subjects. Psychosomatic Medicine, 59, 541–552.PubMed
MacCulloch, M. J., & Williams, C. (1971). On the nature of infantile autism. Acta Psychiatrica Scandinavica, 47, 295–314.PubMed
Mesulam, M. M. (1981). A cortical network for directed attention and unilateral neglect. Annals of Neurology, 10, 309–325.PubMed
Metz, J. R. (1967). Stimulation level preferences of autistic children. Journal of Abnormal Psychology, 72, 529–535.PubMed
Ornitz, E., & Ritvo, E. R. (1976). Medical Assessment. In E. R. Ritvo (Ed.), Autism. Diagnosis, current research and management, (pp. 7–23). New York: Spectrum Publications.
Ornitz, E. M. (1974). The modulation of sensory input and motor output in autistic children. Journal of Autism and Childhood Schizophrenia, 4, 197–215.PubMed
Ornitz, E. M., & Ritvo, E. R. (1968a). Neurophysiologic mechanisms underlying perceptual inconstancy in autistic and schizophrenic children. Archives of General Psychiatry, 19, 22–27.PubMed
Ornitz, E. M., & Ritvo, E. R. (1968b). Perceptual inconstancy in early infantile autism. Archives of General Psychiatry, 18, 76–98.PubMed
Pagani, M., Furlan, R., Pizzinelli, P., Crivellaro, W., Cerutti, S., & Malliani, A. (1989). Spectral analysis of R-R and arterial pressure variabilities to assess sympatho-vagal interaction during mental stress in humans. Journal of Hypertension, 7, S14-S15.PubMed
Pagani, M., Lombardi, F., Guzzetti, S., Rimoldi, O., Furlan, R., Pizzinelli, P., Sandrone, G., Malfatto, G., Dell'Orto, S., Piccaluga, E., Turiel, M., Baselli, G., Cerutti, S., & Malliani, A. (1986). Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circulation Research, 59, l78–193.
Palkovitz, R. J., & Wiesenfeld, A. R. (1980). Differential autonomic responses of autistic and normal children. Journal of Autism and Developmental Disorders, 10, 347–360.PubMed
Perry, R., Campbell, M., Adams, P., Lynch, N., Spencer, E. K., Curren, E. L., & Overall, J. E. (1989). Long-term efficacy of haloperidol in autistic children: Continuous versus discontinuous drug administration. Journal of American Academy of Child and Adolescent Psychiatry, 28, 87–92.
Posner, M. I., Petersen, S. E., Fox, P. T., & Raichle, M. E. (1988). Localization of cognitive operations in the human brain. Science, 240, 1627–1631.PubMed
Raven, J. C. (1960). Standard Progressive Matrices: Sets A, B, C, D and E. London: H. K. Lewis.
Raven, J. C. (1962). Coloured Progressive Matrices: Sets A, AB, B. London: H. K. Lewis.
Raven, J. C., Court, J. H., & Raven, J. (1995). Section 2. Coloured Progressive Matrices. (1995 edition). Oxford: Oxford Psychologists Press.
Rimland, B. (1964). Infantile autism. The syndrome and its implication for a natural theory of behavior. New York: Meredith Publishing Company.
Robbins, T. W., & Everitt, B. J. (1995). Arousal system and attention. In M. S. Gazzaniga (ed.), The Cognitive Neurosciences, (pp. 703–720). Cambridge, MA: MIT Press.
Rosenblum, S. M., Arick, J. R., Krug, D. A., Stubbs, E. G., Young, N. B., & Pelson, R. O. (1980). Auditory brainstem evoked responses in autistic children. Journal of Autism and Developmental Disorders, 10, 215–225.PubMed
Rutter, M. (1968). Concept of autism: A review of research. Journal of Child Psychology and Psychiatry, 9, 1–25.PubMed
Rutter, M., & Bartak, L. (1971). Causes of infantile autism: Some considerations from recent research. Journal of Autism and Childhood Schizophrenia, 1, 20–32.PubMed
Schechter, M. D., Shurley, J. T., Toussieng, P. W., & Maier, W. J. (1969). Sensory isolation therapy of autistic children: A preliminary report. Journal of Pediatrics, 74, 564–569.PubMed
Schopler, E. (1965). Early infantile autism and receptor processes. Archives of General Psychiatry, 13, 327–335.PubMed
Shinagawa, F., Kobayashi, S., Fujita, K., & Maegawa, H. (1990). Japanese Wechsler Adult Intelligence Scale-Revised. Tokyo: Nihon-Bunka-Kagaku-sha.
Stevens, S., & Gruzelier, J. (1984). Electrodermal activity to auditory stimuli in autistic, retarded, and normal children. Journal of Autism and Developmental Disorders, 14, 245–260.PubMed
Student, M., & Sohmer, H. (1978). Evidence from auditory nerve and brainstem evoked responses for an organic brain lesion in children with autistic traits. Journal of Autism and Childhood Schizophrenia, 8, 13–20.PubMed
Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996). Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Circulation, 93, 1043–1065.
Toichi, M., Murai, T., Sengoku, A., & Miyoshi, K. (1998). Interictal change in cardiac autonomic function associated with EEG abnormalities and clinical symptoms: A longitudinal study following acute deterioration in two patients with temporal lobe epilepsy. Psychiatry and Clinical Neurosciences, 52, 499–505.CrossRefPubMed
Van Engeland, H. (1984). The electrodermal orienting response to auditive stimuli in autistic children, mentally retarded children, and child psychiatric patients. Journal of Autism and Developmental Disorders, 14, 261–279.PubMed
Young, J. G., Cohen, D. J., Brown, S., & Caparulo, B. K. (1978). Decreased urinary free catecholamines in childhood autism. Journal of American Academy of Child Psychiatry, 17, 671–678.
- Paradoxical Autonomic Response to Mental Tasks in Autism
Journal of Autism and Developmental Disorders
Volume 33, Issue 4 , pp 417-426
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers-Plenum Publishers
- Additional Links
- autonomic function
- heart rate
- mental task
- Industry Sectors
- Author Affiliations
- 1. Division of Child & Adolescent Psychiatry, Case Western Reserve University/University Hospitals of Cleveland, Ohio;
- 2. Health and Medical Services Center, Shiga University, Japan
- 3. Department of Neuropsychiatry, Faculty of Medicine, Kyoto Graduate University, Kyoto, Japan