Skip to main content
SpringerLink
Log in

Nanoparticle systems for the targeted release of active principles of proteic nature

  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

The preparation and characterization of nanoparticles based on biodegradable/bioerodible polymers is reported. They have been designed for the controlled-targeted release of proteic drugs such as α-interferon and for the release of active principles in tissue engineering. The amenability of some of the prepared polymeric matrices to be used in the fabrication of micro and nano patterned scaffolds is also described.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. L. G. Griffith, Acta Mater. 48 (2000) 263.

    Google Scholar 

  2. K. E. Uhrich, S. M. Cannizzaro, R. S. Langer and K. M. Shakesheff, Chem. Rev. 99 (1999) 3181.

    Google Scholar 

  3. R. S. Langer, Nature 392 (1998) 5.

    Google Scholar 

  4. A. Vila, A. Sanchez, M. Tobio, P. Calvo and M. J. Alonso, J. Controlled Release 78 (2002) 15.

    Google Scholar 

  5. K. S. Soppimath, T. M. Aminabhavi, A. R. Kulkarni and W. E. Rudzinski, ibid. 70 (2001) 1.

    Google Scholar 

  6. A. S. G. Curtis and M. Riehle, Phys. Med. Biol. 46 (2002) R47.

    Google Scholar 

  7. C. D. W. Wilkinson, M. Riehle, M. Wood, J. Gallagher and A. S. G. Curtis, Mat. Sci. Eng. 19 (2002) 263.

    Google Scholar 

  8. W. M. Saltzman and W. L. Olbricht, Nature Rev. 11 (2002) 177.

    Google Scholar 

  9. R. G. Flemming, C. J. Murphy, G. A. Abrams, S. L. Goodman and P. F. Nealey, Biomaterials 20 (1999) 573.

    Google Scholar 

  10. J. KreuterColloidal Drug Delivery Systems, edited by J. Swarbrick (Marcel Dekker Inc., New York, 1994).

    Google Scholar 

  11. E. Chiellini, E. E. Chiellini, F. Chiellini and R. Solaro, J. Bioact. Compat. Polym. 16 (2001) 441.

    Google Scholar 

  12. E. Chiellini, R. Solaro, G. Leonardi, D. Giannasi, R. Lisciani and G. Mazzanti, J. Controlled Release 22 (1992) 273.

    Google Scholar 

  13. R. Solaro, S. D'Antone, L. Bemporad and E. Chiellini, J. Bioact. Compat. Polym. 8 (1993) 236.

    Google Scholar 

  14. E. Chiellini, L. Bemporad and R. Solaro, ibid. 9 (1994) 152.

    Google Scholar 

  15. R. Solaro, E. Dossi, E. Chiellini and G. Mazzanti, ibid. 12 (1997) 27.

    Google Scholar 

  16. R. Bizzarri, R. Solaro and E. Chiellini, ibid. 14 (1999) 504.

    Google Scholar 

  17. S. Miertus, A. C. Nair, V. Frecher, E. Chiellini, F. Chiellini, R. Solaro and J. Tomasi, J. Incl. Phenom. Macrom. Chem. 34 (1999) 69.

    Google Scholar 

  18. E. Chiellini, R. Bizzarri, P. Bonaguidi, P. Talamelli and R. Solaro, J. Macromol. Sci.-Pure Appl. Chem. A 36 (1999) 901.

    Google Scholar 

  19. E. Chiellini, G. Leonardi, R. Solaro, R. Lisciani and G. Mazzanti, PCT to Istituo Sierovaccinogeno Italiano. Eur. Pat. EP0, 509, 968 (1992).

  20. E. Chiellini, E. E. Chiellini, F. Chiellini and R. SolaroPolymeric Drugs and Drug Delivery Systems, edited by R. M. Ottenbrite and K. S. Wang (Technomic Publishing, Lancaster, PA, 2001).

    Google Scholar 

  21. V. Bocci, Clin. Pharmacokinet. 21 (1991) 274.

    Google Scholar 

  22. C. H. Spiridomidis, Drugs of Today 27 (1991) 35.

    Google Scholar 

  23. G. Ashwell and J. Harford, Ann. Rev. Biochem. 51 (1982) 531.

    Google Scholar 

  24. A. Carlsson, E. E. Chiellini, F. Chiellini, J. Cowdall, J. Davies, G. Mazzanti, M. Roberts, E. Soderlind and R. Solaro, Ital. Pat. IT1293087 (1997); PTC WO9902131 (1999).

  25. A. Carlsson, E. Chiellini, E. E. Chiellini, J. Cowdall, J. Davies, G. Mazzanti, M. Roberts, E. Soderlind and R. Solaro, Ital. Pat. IT1293088 (1997); PCT WO9902135 (1999).

  26. V. H. LeePeptide and Protein Drug Delivery, edited by V. H. Lee (Dekker, New York, 1991).

    Google Scholar 

  27. J. L. Cleland and A. J. S. Jones, US Pat. Appl. US/94/01666; WO Pat. Appl. 94/19020 (1994).

  28. H. Yoshioka, T. Ohmura, M. Hasegawa, S. Hirota, M. Makino and M. Kamiya, J. Pharm. Sci. 82 (1993) 273.

    Google Scholar 

  29. E. Chiellini, E. E. Chiellini, F. Chiellini and R. Solaro, Polym. Prepr. (ACS) 39 (1998) 182.

    Google Scholar 

  30. P. Fournie, D. Domoraud, P. Guerin, C. Braud, M. Vert and R. Pontikis, J. Bioact. Compat. Polym. 7 (1992) 113.

    Google Scholar 

  31. C. Braud and M. Vert, Polym. Bull. 29 (1992) 177.

    Google Scholar 

  32. S. Cammas-Marion and P. Guerin, Macromol. Symp. 153 (2000) 167.

    Google Scholar 

  33. C. Barbaud, S. Cammas-Marion and P. Guerin, Polym. Bull. 43 (1999) 297.

    Google Scholar 

  34. S. Cammas-Marion, M. Bear, A. Harada, P. Guerin and K. Kataoka, Macromol. Chem. Phys. 201 (2000) 355.

    Google Scholar 

  35. S. Cammas-Marion, M. Bear, L. Moine, R. Escalup, G. Ponchel, K. Kataoka and P. Guerin, Int. J. Biol. Macromol. 25 (1999) 273.

    Google Scholar 

  36. L. Moine, S. Cammas, C. Amiel, E. Renard, B. Sebille and P. Guerin, Macromol. Symp. 130 (1998) 45.

    Google Scholar 

  37. H. Rossignol, M. Boustta and M. Vert, Int. J. Biol. Macromol. 25 (1999) 255.

    Google Scholar 

  38. S. Stolnik, M. C. Davies, L. Illum, S. S. Davis, M. Boustta and M. Vert, J. Controlled Release 30 (1994) 57.

    Google Scholar 

  39. R. Bizzarri, F. Chiellini, R. Solaro, E. Chiellini, S. Cammas-Marion and P. Guerin, Macromolecules 35 (2002) 1215.

    Google Scholar 

  40. F. Chiellini, C. Fiumi, F. Signori and C. Boggi, Proceedings of the International Meeting on Advanced Frontiers in Polymer Science (Pisa, Italy, 2002) 23.

  41. M. S. Jhon and J. D. Andrade, J. Biomed. Mater. Res. 7 (1973) 509.

    Google Scholar 

  42. O. Wichterle and D. Lim, Nature 185 (1960) 117.

    Google Scholar 

  43. F. Chiellini, F. Petrucci, E. Ranucci and R. Solaro, J. Appl. Polym. Chem. 85 (2002) 2729.

    Google Scholar 

  44. F. Chiellini, R. Bizzarri, C. K. Ober, D. Schmaljohan, R. Solaro and E. Chiellini, Macromol. Rapid Commun. 22 (2001) 1284.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry and Industrial Chemistry, University of Pisa, via Risorgimento 35, 56126, Pisa, Italy

    R. Solaro, F. Chiellini, F. Signori, C. Fiumi, R. Bizzarri & E. Chiellini

Authors
  1. R. Solaro
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Chiellini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. Signori
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Fiumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. Bizzarri
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E. Chiellini
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to R. Solaro.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Solaro, R., Chiellini, F., Signori, F. et al. Nanoparticle systems for the targeted release of active principles of proteic nature. Journal of Materials Science: Materials in Medicine 14, 705–711 (2003). https://doi.org/10.1023/A:1024963700223

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1024963700223

Keywords

Search

Navigation