Article

Genetica

, Volume 118, Issue 2, pp 157-170

The Fucosyltransferase Gene Family: An Amazing Summary of the Underlying Mechanisms of Gene Evolution

  • Christophe JavaudAffiliated withUnité de Génétique Moléculaire Animale
  • , Fabrice DupuyAffiliated withEA 3176, Institut des Sciences de la Vie et de la Santé, Faculté des Sciences, Laboratoire de Glycobiologie et Biotechnologie
  • , Abderrahman MaftahAffiliated withEA 3176, Institut des Sciences de la Vie et de la Santé, Faculté des Sciences, Laboratoire de Glycobiologie et Biotechnologie
  • , Raymond JulienAffiliated withUnité de Génétique Moléculaire Animale Email author 
  • , Jean-Michel PetitAffiliated withUnité de Génétique Moléculaire Animale

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Abstract

The fucosyltransferase gene family encodes enzymes that transfer fucose in α1,2, α1,3/4 and α1,6 linkages on a large variety of glycans. The most ancient genes harbour a split coding sequence, and encode enzyme that transfer fucose at or near O- and N-peptidic sites (serine, threonine or chitobiose unit). Conversely, the more recent genes have a monoexonic coding sequence, and encode enzymes that transfer fucose at the glycan periphery. All basic mechanisms of gene evolution contribute to this amazing scenario: exon shuffling, transposition, point mutations, and duplication. As typical examples: (i) exon shuffling leads to the ancestral organization of the α1,6 fucosyltransferase gene; (ii) the ancestor of α1,2 fucosyltransferase genes is reshaped by retrotransposition at the same locus; (iii) duplication associated to point mutations leads to the most recent α1,3/4 fucosyltransferase genes.

duplication evolution fucosyltransferase mutation pseudogenes retrotransposition