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Verbal Declarative Memory Dysfunction in Schizophrenia: From Clinical Assessment to Genetics and Brain Mechanisms

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Abstract

The recent literature on the neuropsychology of schizophrenia has emphasized memory deficits as a key area of impairment. Abnormalities in the medial temporal lobe, a brain region crucial for long-term memory formation, have also consistently been reported. We conducted a comprehensive review of verbal declarative memory (VDM) in schizophrenia with the aim of systematically addressing the nature of this impairment. We conclude that verbal declarative memory is significantly impaired in schizophrenia and is largely accounted for by deficits in the encoding stage. Subtle impairments in increased rates of forgetting are present, but are mild compared with those in amnestic disorders. Impairment in other cognitive domains studied thus far (e.g., attention), medication effects, or fluctuations in symptoms do not completely account for the deficit. VDM is among the most impaired neurocognitive domains in schizophrenia (along with attention and executive functions). Milder encoding deficits are present in high-risk subjects and non-psychotic relatives of individuals with schizophrenia suggesting that components of the deficit are associated with a genetic vulnerability to the illness, and are independent of the frank psychotic illness. Furthermore, VDM is observed in individuals experiencing their first-psychotic episode and it remains fairly consistent over time. Preliminary imaging studies and other work suggest abnormalities in prefrontal-hippocampal processing networks. Future work should emphasize delineating specific information processing components contributing to the deficit. This would allow imaging studies to determine which brain regions contribute to specific information processing deficits in schizophrenia.

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REFERENCES

  • Abbruzzese, M., and Scarone, S. (1993). Memory and attention dysfunctions in story recall in schizophrenia: Evidence of a possible frontal malfunctioning. Biol. Psychol. 35: 51-58.

    PubMed  Google Scholar 

  • Addington, J., Addington, D., and Maticka-Tyndale, E. (1991). Cognitive functioning and positive and negative symptoms in schizophrenia. Schizophr. Res. 5: 123-134.

    PubMed  Google Scholar 

  • Adler, L. E., Pachtman, E., Franks, R. D., Pechevich, M., Waldo, M. C., and Freedman, R. (1982). Neurophysiological evidence for a defect in neural mechanisms involved in sensory gating in schizophrenia. Biol. Psychiatry 17: 639-654.

    PubMed  Google Scholar 

  • Adler, L. E., Olincy, A., Waldo, M., Harris, J. G., Griffith, J., Stevens, K., et al. (1998). Schizophrenia, sensory gating, and nicotinic receptors. Schizophr. Bull. 24: 189-202.

    PubMed  Google Scholar 

  • Aggleton, J. P., and Shaw, C. (1996). Amnesia and recognition memory: A re-analysis of psychometric data. Neuropsychologia 34: 51-62.

    PubMed  Google Scholar 

  • Albus, M., Hubman, W., Ehrenberg, C., Forcht, U., Mohr, F., Sobizack, N., et al. (1996). Neuropsychological impairment in first-episode and chronic schizophrenic patients. Eur.Arch. Psychiatry Clin. Neurosci. 246: 249-255.

    PubMed  Google Scholar 

  • Aleman, A., Hijman, R., de Haan, E. H. F., and Kahn, R. S. (1999). Memory impairment in schizophrenia: A meta-analysis. Am. J. Psychiatry 156: 1358-1366.

    PubMed  Google Scholar 

  • American Psychiatric Association. (1980). Diagnostic and statistical manual of mental disorder (3rd ed.). Washington, DC: Author.

    Google Scholar 

  • Ammons, R. B., and Ammons, C. H. (1962). The Quick Test (QT): Provisional Manual. Psychological Reports (Monograph Supplement I-VII), 111-161.

  • Arango, C., Bartko, J. J., Gold, J. M., and Buchanan, R.W. (1999). Prediction of neuropsychological performance by neurological signs in schizophrenia. Am. J. Psychiatry 156: 1349-1357.

    PubMed  Google Scholar 

  • Atkinson, R. C., and Shiffrin, R. M. (1968). Human memory: A proposed system and its control processes. In: Spence, K.W. (ed.), The Psychology of Learning and Motivation: Advances in Research and Theory, Academic Press, New York, pp. 89-195.

    Google Scholar 

  • Aylward, E., Walker, E., and Bettes, B. (1984). Intelligence in schizophrenia: Meta-analysis of the research. Schizophr. Bull. 10: 430-459.

    PubMed  Google Scholar 

  • Baaré, W. F. C., Hulshoff Pol, H. E., Hilman, R., Mali, W. P. T., Viergever, M. A., and Kahn, R. S. (1999). Volumetric analysis of frontal lobe regions in schizophrenia: Relation to cognitive function and symptomatology. Biol. Psychiatry 45: 1597-1605.

    PubMed  Google Scholar 

  • Baddeley, A. D. (2000). Short-term and working memory. In: Tulving, E., and Craik, F. I. M. (eds.), The Oxford Handbook of Memory, Oxford University Press, New York, pp. 77-92.

    Google Scholar 

  • Baddeley, A. D., and Hitch, G. J. (1974). Working memory. In: Bower, G. A. (ed.), The Psychology of Learning and Motivation, Academic Press, New York, pp. 47-89.

    Google Scholar 

  • Baker, L. A., Cheng, L. Y., and Amara, I. B. (1983). The withdrawal of benztropine mesylate in chronic schizophrenic patients. Br. J. Psychiatry 143: 584-590.

    PubMed  Google Scholar 

  • Barker, W. J. (1977). The role of retrieval in schizophrenic memory process. Can. J. Behav. Sci. 9: 176-186.

    Google Scholar 

  • Basso, M. R., Nasrallah, H. A., Olson, S. C., and Bornstein, R. A. (1998). Neuropsychological correlates of negative, disorganized and psychotic symptoms in schizophrenia. Schizophr. Res. 31: 99-111.

    PubMed  Google Scholar 

  • Bassos, C. A. (1973). Affective content and contextual constraint in recall by paranoid, nonparanoid, and nonpsychiatric patients. J. Consult. Clin. Psychol. 40: 126-132.

    PubMed  Google Scholar 

  • Bauer, R. M., Tobias, B., and Valenstein, E. (1993). Amnesic disorders. In: Heilman, K. M., and Valenstein, E. (eds.), Clinical Neuropsychology, Oxford University Press, New York, pp. 523-602.

    Google Scholar 

  • Bauman, E. (1971). Schizophrenic short-term memory: The role of organization at input. J. Consult. Clin. Psychol. 36: 14-19.

    PubMed  Google Scholar 

  • Bauman, E., and Murray, D. J. (1968). Recognition versus recall in schizophrenia. Can. J. Psychol. 22: 18-25.

    PubMed  Google Scholar 

  • Beatty, W. M., Jocic, Z., Monson, N., and Staton, R. D. (1993). Memory and frontal lobe dysfunction in schizophrenia and schizoaffective disorder. J. Nerv. Ment. Dis. 181: 448-453.

    PubMed  Google Scholar 

  • Benes, F. M. (1999). Evidence for altered trisynaptic circuitry in schizophrenic hippocampus. Biol. Psychiatry 46: 589-599.

    PubMed  Google Scholar 

  • Berg, P. A., and Leventhal, D. B. (1977). The effect of distractor strength versus rate of item presentation on retention in individuals with schizophrenia. Br. J. Soc. Clin. Psychol. 16: 147-152.

    PubMed  Google Scholar 

  • Bilder, R. M., Mukherjee, S., Reider, R. O., and Pandurangi, A. K. (1985). Symptomatic and neuropsychological components of defect states. Schizophr. Bull. 11: 409-419.

    PubMed  Google Scholar 

  • Bilder, R. M., Goldman, R. S., Robinson, D., Reiter, G., Bell, L., Bates, J. A., et al. (2000). Neuropsychology of first-episode schizophrenia: Initial characterization and clinical correlates. Am. J. Psychiatry 157: 549-559.

    PubMed  Google Scholar 

  • Binder, J., Albus, M., Hubmann, W., Scherer, J., Sobizack, N., Franz, U., et al. (1998). Neuropsychological impairment and psychopathology in first-episode schizophrenic patients related to the early course of illness. Eur. Arch. Psychiatry Clin. Neurosci. 248: 70-77.

    PubMed  Google Scholar 

  • Blanchard, J. J., and Neale, J. M. (1994). The neuropsychological signature of schizophrenia: Generalized or differential deficit? Am. J. Psychiatry 151: 40-48.

    PubMed  Google Scholar 

  • Bleuler, E. (1950). Dementia Praecox (translated by J. Zinkin), International Universities Press, New York.

    Google Scholar 

  • Bornstein, R. A., Nasrallah, H. A., Olson, S. C., Coffman, J. A., Torello, M., and Schwarzkopf, S. B. (1990). Neuropsychological deficit in schizophrenic subtypes: Paranoid, non-paranoid, and schizoaffective subgroups. Psychiatry Res. 31: 15-24.

    PubMed  Google Scholar 

  • Braff, D. L., Heaton, R., Kuck, J., Cullum, M., Moranville, J., Grant, I., et al. (1991). The generalized pattern of neuropsychological deficits in outpatients with chronic schizophrenia with heterogeneous Wisconsin Card Sorting Test Results. Arch. Gen. Psychiatry 48: 891-898.

    PubMed  Google Scholar 

  • Brébion, G., Amador, X., Smith, M.J., and Gorman, J.M.(1997a). Mechanisms underlying memory impairment in schizophrenia. Psychol. Med. 27: 383-393.

    PubMed  Google Scholar 

  • Brébion, G., Smith, M. J., Amador, X., Malaspina, D., and Gorman, J. (1997b). Clinical correlates of memory in schizophrenia: Differential links between depression, positive and negative symptoms, and two types of memory impairment. Am. J. Psychiatry 154: 1538-1543.

    PubMed  Google Scholar 

  • Brébion, G., Amador, X., Smith, M. J., and Gorman, J. M. (1998). Memory impairment and schizophrenia: The role of processing speed. Schizophr. Res. 30: 31-39.

    PubMed  Google Scholar 

  • Brébion, G., Smith, M. J., Gorman, J. M., Malaspina, D., Sharif, Z., and Amador, X. (2000). Memory and schizophrenia: Differential link of processing speed and selective attention with two levels of encoding. J. Psychiatr. Res. 34: 121-127.

    PubMed  Google Scholar 

  • Brébion, G., Gorman, J. M., Malaspina, D., Sharif, Z., and Amador, X. (2001). Clinical and cognitive factors associated with verbal memory task performance in patients with schizophrenia. Am. J. Psychiatry 158: 758-764.

    PubMed  Google Scholar 

  • Brodal, P. (1992). The Central Nervous System: Structure and Function, Oxford University Press, New York.

    Google Scholar 

  • Broga, M. I., and Neufeld, R. W. J. (1981). Multivariate cognitive performance levels and response styles among paranoid and nonparanoid schizophrenics. J. Abnorm. Psychol. 90: 495-509.

    PubMed  Google Scholar 

  • Buchanan, R. W., Strauss, M. E., Kirkpatrick, B., Holstein, C., Breier, A., and Carpenter, W. T. (1994). Neuropsychological impairment in deficit versus nondeficit forms of schizophrenia. Arch. Gen. Psychiatry 51: 804-811.

    PubMed  Google Scholar 

  • Buckley, P. F., Moore, C., Long, H., Larkin, C., Thompson, P., Mulvany, F., et al. (1994). H-Magnetic resonance spectroscopy of the left temporal, and frontal lobes in schizophrenia: Clinical, neurodevelopmental, and cognitive correlates. Biol. Psychiatry 36: 792-800.

    PubMed  Google Scholar 

  • Buckner, R. L., and Koutstaal, W. (1998). Functional neuroimaging studies of encoding, priming, and explicit memory retrieval. Proc. Natl. Acad. Sci. USA 95: 891-898.

    PubMed  Google Scholar 

  • Buckner, R. L., Kelley, W. M., and Petersen, S. E. (1999). Frontal cortex contributes to human memory formation. Nat. Neurosci. 2: 311-314.

    PubMed  Google Scholar 

  • Busatto, G. F., Costa, D. C., Ell, P. J., Pilowsky, L. S., David, A. S., and Kerwin, R. W. (1994). Regional cerebral blood flow (rCBF) in schizophrenia during verbal memory activation:A99mTc-HMPAO single photon emission tomography (SPET) study. Psychol. Med. 24: 463-472.

    PubMed  Google Scholar 

  • Busatto, G. F., David, A. S., Costa, D. C., Ell, P. J., Pilowsky, L. S., Lucey, J. V., et al. (1995). Schizophrenic auditory hallucinations are associated with increased regional cerebral blood flow during verbal memory activation in a study using single photon emission computed tomography. Psychiatry Res. 61: 255-264.

    PubMed  Google Scholar 

  • Butters, N., Salmon, D. P., Cullum, C. M., Cairns, P., Tröster, A. I., and Jacobs, D. (1988). Differentiation of amnesic and demented patients with the Wechsler Memory Scale-Revised. Clin. Neuropsychol. 2: 133-148.

    Google Scholar 

  • Byrne, M., Hodges, A., Grant, E., Owens, D. C., and Johnstone, E. C. (1999). Neuropsychological assessment of young people at high genetic risk for developing schizophrenia compared with controls: Preliminary findings of the Edinburgh High Risk Study (EHRS). Psychol. Med. 29: 1161-1173.

    PubMed  Google Scholar 

  • Calev, A. (1984a). Recall and recognition in chronic nondemented individuals with schizophrenia: Use of matched tasks. J. Abnorm. Psychol. 93: 172-177.

    PubMed  Google Scholar 

  • Calev, A. (1984b). Recall and recognition in mildly disturbed individuals with schizophrenia: Use of matched tasks. Psychol. Med. 14: 425-429.

    PubMed  Google Scholar 

  • Calev, A., and Monk, A. F. (1982). Verbal memory tasks showing no deficit in schizophrenia-fact or artefact? Br. J. Psychiatry 141: 528-530.

    Google Scholar 

  • Calev, A., Venables, P. H., and Monk, A. F. (1983). Evidence for distinct verbal memory pathologies in severely and mildly disturbed individuals with schizophrenia. Schizophr. Bull. 9: 247-264.

    PubMed  Google Scholar 

  • Calev, A., Berlin, H., and Lerer, B. (1987a). Remote and recent memory in long hospitalized chronic individuals with schizophrenia. Biol. Psychiatry 22: 79-85.

    PubMed  Google Scholar 

  • Calev, A., Korin, Y., Kugelmass, S., and Lerer, B. (1987b). Performance of individuals with schizophrenia on matched word and design recall tasks. Biol. Psychiatry 22: 699-709.

    PubMed  Google Scholar 

  • Calev, A., Edelist, S., Kugelmass, S., and Lerer, B. (1991a). Performance of long-stay individuals with schizophrenia on matched verbal and visuospatial recall tasks. Psychol. Med. 21: 655-660.

    PubMed  Google Scholar 

  • Calev, A., Nigal, D., Kugelmass, S., Weller, P. I., and Lerer, B. (1991b). Performance of long-stay individuals with schizophrenia after drug withdrawal on matched immediate and delayed recall tasks. Br. J. Clin. Psychol. 30: 241-245.

    PubMed  Google Scholar 

  • Calhoun, J. F. (1970). Effects of performance payoff and cues on recall by hospitalized individuals with schizophrenia. J. Abnorm. Psychol. 76: 485-491.

    PubMed  Google Scholar 

  • Calhoun, J. F., and Moss, R. A. (1981). The role of level of functioning in the modification of psychological deficits in individuals with schizophrenia. J. Psychiatr. Res. 16: 205-211.

    PubMed  Google Scholar 

  • Cannon, T. D., Mednick, S. A., Parnas, J., Schulsinger, F., Praestholm, J., and Vestergaard, A. (1993). Developmental brain abnormalities in the offspring of schizophrenic mothers. Arch. Gen. Psychiatry 50: 551-564.

    PubMed  Google Scholar 

  • Cantor-Graae, E., Warkentin, S., and Nilsson, A. (1995). Neuropsychological assessment of schizophrenic patients during a psychotic episode: Persistent cognitive deficit. Acta Psychiatr. Scand. 87: 283-288.

    Google Scholar 

  • Cassens, G., Inglis, A. K., Appelbaum, P. S., and Gutheil, T. G. (1990). Neuroleptics: Effects on neuropsychological function in chronic schizophrenic patients. Schizophr. Bull. 16: 477-499.

    PubMed  Google Scholar 

  • Chan, A. S., Kwok, I. C., Chiu, H., Lam, L., Pang, A., and Chow, L. (2000). Memory and organizational strategies in chronic and acute schizophrenic patients. Schizophr. Res. 41: 431-445.

    PubMed  Google Scholar 

  • Chapman, L. J., and Chapman, J. P. (1978). The measurement of differential deficit. J. Psychiatr. Res. 14: 303-311.

    PubMed  Google Scholar 

  • Chapman, L. J., and Chapman, J. P. (1989). Strategies for resolving the heterogeneity of individuals with schizophrenia and their relatives using cognitive measures. J. Abnorm. Psychol. 98: 357-366.

    PubMed  Google Scholar 

  • Chen, E. Y., Lam, L. C., Chen, R. Y., Nguyen, D. G., Chan, C. K., and Wilkins, A. J. (1997). Neuropsychological correlates of sustained attention in schizophrenia. Schizophr. Res. 24: 299-310.

    PubMed  Google Scholar 

  • Cohen, N. J., and Eichenbaum, H. (1993). Memory, Amnesia, and the Hippocampal System, Cambridge, The MIT Press.

    Google Scholar 

  • Colombo, C., Abbruzzese, M., Livian, S., Scotti, G., Locatelli, M., Bonfanti, A., et al. (1993). Memory functions and temporal-limbic morphology in schizophrenia. Psychiatry Res. 50: 45-56.

    PubMed  Google Scholar 

  • Condray, R., Steinhauer, S. R., van Kammen, D. P., and Kasparek, A. (1996). Working memory capacity predicts language comprehension in schizophrenic patients. Schizophr. Res. 20: 1-13.

    PubMed  Google Scholar 

  • Cornblatt, B. A., and Keilp, J. G. (1994). Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr. Bull. 20: 31-46.

    PubMed  Google Scholar 

  • Cowan, N. (1988). Evolving conceptions of memory storage, selective attention, and their mutual contraints within the human informationprocessing system. Psychol. Bull. 104: 163-191.

    PubMed  Google Scholar 

  • Cowan, N. (1997). Attention and Memory, Oxford University Press, New York.

    Google Scholar 

  • Craik, F. I. M., and Lockhart, R. S. (1972). Levels of processing: A framework for memory research. J. Verb. Learn. Verb. Behav. 11: 671-684.

    Google Scholar 

  • Craik, F. I. M., and Tulving, E. (1975). Depth of processing and the retention of words in episodic memory. J. Exp. Psychol. Gen. 3: 268-294.

    Google Scholar 

  • Crespo-Facorro, B., Paradiso, S., Andreasen, N. C., O'Leary, D. S., Watkins, G. L., Ponto, L. L. B., et al. (1999). Recallingword lists reveals "cognitive dysmetria" in schizophrenia: A positron emission tomography study. Am. J. Psychiatry 156: 386-392.

    PubMed  Google Scholar 

  • Cuesta, M. J., and Peralta, V. (1995). Cognitive disorders in the positive, negative, and disorganization syndromes of schizophrenia. Psychiatry Res. 58: 227-235.

    PubMed  Google Scholar 

  • Culver, L. C., Kunen, S., and Zinkgraf, S. A. (1986). Patterns of recall in individuals with schizophrenia and normal subjects. J. Nerv. Ment. Dis. 174: 620-623.

    PubMed  Google Scholar 

  • Cutting, J. (1979). Memory in functional psychosis. J. Neurol. 42: 1031-1037.

    Google Scholar 

  • Delis, D. C., Kramer, J. H., Kaplan, E., and Ober, B. A. (1987). The California Verbal Learning Test-Research Edition, Psychological Corporation, New York.

    Google Scholar 

  • Delis, D. C., Massman, P. J., Butters, N., Salmon, D. P., Cermak, L. S., and Kramer, J. H. (1991). Profiles of demented and amnesic patients on the California Verbal Learning Test: Implications for the assessment of memory disorders. Psychol. Assess. 3: 19-26.

    Google Scholar 

  • DeLisi, L. E. (2001). Speech disorder in schizophrenia: Review of the literature and exploration of its relation to the uniquely human capacity for language. Schizophr. Bull. 27: 481-496.

    PubMed  Google Scholar 

  • Dickerson, F. B., Ringel, N. B., and Boronow, J. J. (1991). Neuropsychological deficits in chronic individuals with schizophrenia. Relationship with symptoms and behavior. J. Nerv. Ment. Dis. 179: 744-749.

    Google Scholar 

  • Duffy, L., and O'Carroll, R. (1994). Memory impairment in schizophrenia-a comparison with that observed in the Alcoholic Korsakoff Syndrome. Psychol. Med. 24: 155-165.

    PubMed  Google Scholar 

  • Durkin, T. P., Messier, C., deBoer, P., and Westerink, B. H. C. (1992). Raised glucose levels enhance scopolamine-induced acetylcholine overflow from the hippocampus: An in vivo microdialysis study in the rat. Behav. Brain Res. 49: 181-188.

    PubMed  Google Scholar 

  • Eitan, N., Levin, Y., Ben-Artzi, E., Levy, A., and Neumann, M. (1992). Effects of antipsychotic drugs on memory functions of schizophrenic patients. Acta Psychiatr. Scand. 85: 74-76.

    PubMed  Google Scholar 

  • Faraone, S. V., Seidman, L. J., Kremen, W. S., Toomey, R., Pepple, J. R., Lyons, M. J., et al. (1995). Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: A diagnostic efficiency analysis. J. Abnorm. Psychol. 104: 286-304.

    PubMed  Google Scholar 

  • Faraone, S. V., Seidman, L. J., Kremen, W. S., Toomey, R., Pepple, J. R., and Tsuang, M. T. (1999). Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: A four-year follow-up study. J. Abnorm. Psychol. 108: 176-181.

    PubMed  Google Scholar 

  • Faraone, S. V., Seidman, L. J., Kremen, W. S., Toomey, R., Pepple, J. R., and Tsuang, M. T. (2000). Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: The effect of genetic loading. Biol. Psychiatry 48: 120-126.

    PubMed  Google Scholar 

  • Fayen, M., Goldman, M. B., Moulthrop, M. A., and Luchins, D. J. (1988). Differential memory function with dopaminergic versus anticholinergic treatment of drug-induced extrapyramidal symptoms. Am. J. Psychiatry 145: 483-486.

    PubMed  Google Scholar 

  • Fernández, G., and Tendolkar, I. (2001). Integrated brain activity in medial temporal and prefrontal areas predicts subsequent memory performance: Human declarative memory formation at the system level. Brain Res. Bull. 55: 1-9.

    PubMed  Google Scholar 

  • Fletcher, P. C., McKenna, P. J., Frith, C. D., Grasby, P. M., Fristin, K. J., and Dolan, R. J. (1998). Brain activations in schizophrenia during a graded memory task studied with functional imaging. Arch. Gen. Psychiatry 55: 1001-1008.

    PubMed  Google Scholar 

  • Foster, J. K., and Jelicic, M. (eds.) (1999). Memory: Systems, Process, or Function, Oxford University Press, New York.

    Google Scholar 

  • Fucetola, R., Seidman, L. J., Kremen, W. S., Faraone, S. V., Goldstein, J. M., and Tsuang, M. T. (2000). Age and neuropsychological function in schizophrenia: A decline in executive abilities beyond that observed in healthy volunteers. Biol. Psychiatry 48: 137-146.

    PubMed  Google Scholar 

  • Gabrieli, J. D. E., Poldrack, R. A., and Desmond, J. E. (1998). The role of the left prefrontal cortex in language and memory. Proc. Natl. Acad. Sci. USA 95: 906-913.

    PubMed  Google Scholar 

  • Ganguli, R., Carter, C., Mintun, M., Brar, J., Becker, J., Sarma, R., et al. (1997). PET brain mapping study of auditory verbal supraspan memory versus visual fixation in schizophrenia. Biol. Psychiatry 41: 33-42.

    PubMed  Google Scholar 

  • Gilbertson, M. W., and van Kammen, D. P. (1997). Recent and remote memory dissociation: Medication effects and hippocampal function in schizophrenia. Biol. Psychiatry 42: 585-595.

    PubMed  Google Scholar 

  • Gold, J. M., and Harvey, P.D. (1993). Cognitive deficits in schizophrenia. Psychiatr. Clin. North Am. 16: 295-312.

    PubMed  Google Scholar 

  • Gold, J. M., Blaxton, T. A., Hermann, B. P., Randolph, C., Fedio, P., Goldberg, T. E., et al. (1995). Memory and intelligence in lateralized temporal lobe epilepsy and schizophrenia. Schizophr. Res. 17: 59-65.

    PubMed  Google Scholar 

  • Gold, J. M., Randolph, C., Carpenter, C. J., Goldberg, T. E., and Weinberger, D. R. (1992a). The performance of patients with schizophrenia on theWechsler Memory Scale-Revised. Clin. Neuropsychol. 6: 367-373.

    Google Scholar 

  • Gold, J. M., Randolph, C., Carpenter, C. J., Goldberg, T. E., and Weinberger, D. R. (1992b). Forms of memory failure in schizophrenia. J. Abnorm. Psychol. 101: 487-494.

    PubMed  Google Scholar 

  • Gold, J. M., Rehkemper, G., Binks, S. W., 3rd, Carpenter, C. J., Fleming, K., Goldberg, T. E., et al. (2000). Learning and forgetting in schizophrenia. J. Abnorm. Psychol. 109: 534-538.

    PubMed  Google Scholar 

  • Gold, S., Arndt, S., Nopoulos, P., O'Leary, D. S., and Andreasen, N. (1999). Longitudinal study of cognitive function in first-episode and recent-onset schizophrenia. Am. J. Psychiatry 156: 1342-1348.

    PubMed  Google Scholar 

  • Goldberg, T. E., and Weinberger, D. R. (1996). Effects of neuroleptic medications on the cognition of patients with schizophrenia: A review of recent studies. J. Clin. Psychiatry 57: 62-65.

    PubMed  Google Scholar 

  • Goldberg, T. E., Weinberger, D. R., Pliskin, N. H., Berman, K. F., and Podd, M. H. (1989). Recall memory deficit in schizophrenia. A possible manifestation of prefrontal dysfunction. Schizophr. Res. 2: 251-257.

    Google Scholar 

  • Goldberg, T. E., Ragland, J. D., Torrey, E. F., Gold, J. M., Bigelow, L. B., and Weinberger, D. R. (1990). Neuropsychological assessment of monozygotic twins discordant for schizophrenia. Arch. Gen. Psychiatry 47: 1066-1072.

    PubMed  Google Scholar 

  • Goldberg, T. E., Gold, J. M., Greenberg, R., Griffin, S., Schulz, S. C., Pickar, D., et al. (1993a). Contrasts between patients with affective disorders and patients with schizophrenia on a neuropsychological test battery. Am. J. Psychiatry 150: 1355-1362.

    PubMed  Google Scholar 

  • Goldberg, T. E., Torrey, E. F., Gold, J. M., Ragland, J. D., Bigelow, L. B., and Weinberger, D. R. (1993b). Learning and memory in monozygotic twins discordant for schizophrenia. Psychol. Med. 23: 71-85.

    PubMed  Google Scholar 

  • Goldberg, T. E., Torrey, E. F., Gold, J. M., Bigelow, L. B., Ragland, R. D., Taylor, E., et al. (1995). Genetic risk of neuropsychological impairment in schizophrenia: A study of monozygotic twins discordant and concordant for the disorder. Schizophr. Res. 17: 77-84.

    PubMed  Google Scholar 

  • Goldman-Rakic, P. S. (1994). Working memory dysfunction in schizophrenia. J. Neuropsychiatry Clin. Neurosci. 6: 348-357.

    PubMed  Google Scholar 

  • Goldsamt, L. A., Barros, J., Schwartz, B. J., Weinstein, C., and Iqbal, N. (1993). Neuropsychological correlates of schizophrenia. Psychiatr. Ann. 23: 151-157.

    Google Scholar 

  • Goldstein, G., Allen, D. N., and van Kammen, D. P. (1998a). Individual differences in cognitive decline in schizophrenia. Am. J. Psychiatry 155: 1117-1118.

    PubMed  Google Scholar 

  • Goldstein, J. M., Seidman, L. J., Goodman, J. M., Koren, D., Lee, H., Weintraub, S., et al. (1998b). Are there sex differences in neuropsychological functions among schizophrenic patients? Results from a case-control study. Am. J. Psychiatry 155: 1358-1364.

    PubMed  Google Scholar 

  • Goldstein, J. M., Goodman, J. M., Seidman, L. J., Kennedy, D. N., Makris, N., Lee, H., et al. (1999). Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging. Arch. Gen. Psychiatry 56: 537-547.

    PubMed  Google Scholar 

  • Gras-Vincendon, A., Danion, J., Grangé, D., Bilik, M., Willard-Schroeder, D., Sichel, J., et al. (1994). Explicit memory, repetition priming and cognitive skill learning in schizophrenia. Schizophr. Res. 13: 117-126.

    PubMed  Google Scholar 

  • Green, M. F. (1996). What are the functional consequences of neurocognitive deficits in schizophrenia? Am. J. Psychiatry 153: 321-330.

    PubMed  Google Scholar 

  • Green, M. F., and Walker, E. (1985). Neuropsychological performance and positive and negative symptoms in schizophrenia. J. Abnorm. Psychol. 94: 460-469.

    PubMed  Google Scholar 

  • Green, M. F., Kern, R. S., Braff, D. L., and Mintz, J. (2000). Neurocognitive deficits and functional outcome in schizophrenia: Are we measuring the "right stuff"? Schizophr. Bull. 26: 119-136.

    Google Scholar 

  • Gruzelier, J., Seymour, K., Wilson, L., Jolley, A., and Hirsch, S. (1988). Impairment on neuropsychologic tests of temporohippocampal and frontohippocampal functions and word fluency in remitting schizophrenia and affective disorders. Arch. Gen. Psychiatry 45: 623-629.

    PubMed  Google Scholar 

  • Gur, R. E., Jaggi, J. L., Shtasel, D. L., Ragland, J. D., and Gur, R. C. (1994). Cerebral blood flow in schizophrenia: Effects of memory processing on regional activation. Biol. Psychiatry 35: 3-15.

    PubMed  Google Scholar 

  • Gur, R. E., Cowell, P., Turetsky, B. I., Gallacher, F., Cannon, T., Bilker, W., et al. (1998). A follow-up magnetic resonance imaging study of schizophrenia: Relationship of neuroanatomical changes to clinical and neurobehavioral measures. Arch. Gen. Psychiatry 55: 145-152.

    Google Scholar 

  • Hallack, M., Kupsky, W. J., Hotra, J. W., and Irtenkauf, S. M. (1997). Fetal rat brain injury: Effect of transient maternal hypoxemia. Fetal Diagn. Ther. 12: 68-71.

    PubMed  Google Scholar 

  • Harris, J. G., Adler, L. E., Young, D. A., Cullum, C. M., Rilling, L. M., Cicerello, A., et al. (1996). Neuropsychological dysfunction in parents of individuals with schizophrenia. Schizophr. Res. 20: 253-260.

    PubMed  Google Scholar 

  • Harrison, P. J. (1999). The neuropathology of schizophrenia: A critical review of the data and their interpretation. Brain 122: 593-624.

    PubMed  Google Scholar 

  • Harvey, P. D. (2001). Cognitive and functional impairments in elderly patients with schizophrenia: A review of the recent literature. Harv. Rev. Psychiatry 9: 59-68.

    PubMed  Google Scholar 

  • Harvey, P. D., and Keefe, R. S. E. (2001). Studies of cognitive change with treatment in schizophrenia. Am. J. Psychiatry 158: 176-184.

    PubMed  Google Scholar 

  • Harvey, P. D., and Serper, M. R. (1990). Linguistic and cognitive failures in schizophrenia. A multivariate analysis. J. Nerv. Ment. Dis. 178: 487-494.

    Google Scholar 

  • Harvey, P. D., Earle-Boyer, E. A., Wielgus, M. S., and Levinson, J. C. (1986). Encoding, memory, and thought disorder in schizophrenia and mania. Schizophr. Bull. 12: 252-261.

    PubMed  Google Scholar 

  • Hawkins, K. A., Sullivan, T. E., and Choi, E. J. (1997). Memory deficits in schizophrenia: Inadequate assimilation or true amnesia? Findings from theWechsler Memory Scale-Revised. J. Psychiatry Neurosci. 22: 169-179.

    PubMed  Google Scholar 

  • Heaton, R., Paulsen, J. S., McAdams, L. A., Kuck, J., Zisook, S., Braff, D., et al. (1994). Neuropsychological deficits in individuals with schizophrenia: Relationship to age, chronicity, and dementia. Arch. Gen. Psychiatry 51: 469-476.

    PubMed  Google Scholar 

  • Heaton, R. K., Gladsjo, J. A., Palmer, B. W., Kuck, J., Marcotte, T. D., and Jeste, D. V. (2001). Stability and course of neuropsychological deficits in schizophrenia. Am. J. Psychiatry 58: 24-32.

    Google Scholar 

  • Heckers, S. (2001). Neuroimaging studies of the hippocampus in schizophrenia. Hippocampus 11: 520-528.

    PubMed  Google Scholar 

  • Heckers, S., Rauch, S. L., Goff, D., Savage, C. R., Schacter, D. L., Fischman, A. J., et al. (1998). Impaired recruitment of the hippocampus during conscious recollection in schizophrenia. Nat. Neurosci. 1: 319-323.

    Google Scholar 

  • Heckers, S., Goff, D., Schacter, D. L., Savage, C. R., Fischman, A. J., Alpert, N. M., et al. (1999). Functional imaging of memory retrieval in deficit and non-deficit schizophrenia. Arch. Gen. Psychiatry 56: 1117-1123.

    PubMed  Google Scholar 

  • Heinrichs, R. W. (1994). Performance on tests of diencephalichippocampal verbal memory function in schizophrenia, Korsakoff's syndrome and personality disorder. Schizophr. Res. 13: 127-132.

    PubMed  Google Scholar 

  • Heinrichs, R. W., and Awad, A. G. (1993). Neurocognitive subtypes of chronic schizophrenia. Schizophr. Res. 9: 49-58.

    PubMed  Google Scholar 

  • Heinrichs, R. W., and Zakzanis, K. K. (1998). Neurocognitive deficit in schizophrenia: A quantitative review of the evidence. Neuropsychology 12: 426-445.

    PubMed  Google Scholar 

  • Hellewell, J. S. E., Connell, J., and Deakin, J. F. W. (1994). Affect judgment and facial recognition memory in schizophrenia. Psychopathology 27: 255-261.

    PubMed  Google Scholar 

  • Hoff, A. L., Riordan, H., O'Donnell, D. W., Morris, L., and DeLisi, L. E. (1992). Neuropsychological functioning of first-episode schizophreniform patients. Am. J. Psychiatry 149: 898-903.

    PubMed  Google Scholar 

  • Hoff, A. L., Weineke, M., Faustman, W. O., Horon, R., Sakuma, M., Blankfeld, H., et al. (1998). Sex differences in neuropsychological functioning of first-episode and chronically ill schizophrenic patients. Am. J. Psychiatry 155: 1437-1439.

    PubMed  Google Scholar 

  • Hoff, A. L., Sakuma, M., Weineke, M., Horon, R., Kushner, M., and DeLisi, L. E. (1999). Longitudinal neuropsychological follow-up study of patients with first-episode schizophrenia. Am. J. Psychiatry 156: 1336-1341.

    PubMed  Google Scholar 

  • Huron, C., Danion, J. M., Giacomoni, F., Grange, D., Robert, P., and Rizzo, L. (1995). Impairment of recognition memory with, but not without, conscious recollection in schizophrenia. Am. J. Psychiatry 152: 1737-1742.

    PubMed  Google Scholar 

  • Iddon, J. L., McKenna, P. J., Sahakian, B. J., and Robbins, T.W. (1998). Impaired generation and use of strategy in schizophrenia: Evidence from visuospatial and verbal tasks. Psychol. Med. 28: 1049-1062.

    PubMed  Google Scholar 

  • Javitt, D. C., Strous, R. D., Grochowski, S., Ritter, W., and Cowan, N. (1997). Impaired precision, but normal retention, of auditory sensory ("echoic") memory information in schizophrenia. J. Abnorm. Psychol. 106: 315-324.

    PubMed  Google Scholar 

  • Jeste, D. V., Heaton, S. C., Paulsen, J. S., Ercoli, L., Harris, J., and Heaton, R. K. (1996). Clinical and neuropsychological comparison of psychotic depression with nonpsychotic depression and schizophrenia. Am. J. Psychiatry 153: 490-496.

    PubMed  Google Scholar 

  • Johnsen, M. H., and Magaro, P. A. (1987). Effects of mood and severity of illness on memory process in depression and mania. Psychol. Bull. 101: 28-40.

    PubMed  Google Scholar 

  • Jones, P., and Cannon, M. (1998). The new epidemiology of schizophrenia. Psychiatr. Clin. North Am. 21: 1-25.

    PubMed  Google Scholar 

  • Kareken, D. A., Moberg, P. J., and Gur, R. (1996). Proactive inhibition and semantic organization: Relationship with verbal memory in patients with schizophrenia. J. Int. Neuropsychol. Soc. 2: 486-493.

    PubMed  Google Scholar 

  • Katz, I. R., Greenberg, W. M., Barr, G. A., Garbarino, C., Buckley, P., and Smith, D. (1985). Screening for cognitive toxicity of anticholinergic drugs. J. Clin. Psychiatry 46: 323-326.

    PubMed  Google Scholar 

  • Kay, S. R. (1982). Conceptual disorder in schizophrenia as a function of encoding orientation. J. Nerv. Ment. Dis. 170: 154-163.

    PubMed  Google Scholar 

  • Kempermann, G., Kuhn, H. G., and Gage, F. H. (1997). More hippocampal neurons in adult mice living in an enriched environment. Nature 386: 493-495.

    PubMed  Google Scholar 

  • Kenny, J. T., and Meltzer, H. Y. (1991). Attention and higher cortical functions in schizophrenia. J. Neuropsychiatry Clin. Neurosci. 3: 269-275.

    PubMed  Google Scholar 

  • Kern, R. S., Green, M. F., Marshall, B. D., Wirshing, W. C., Wirshing, D., McGurk, S. R., et al. (1999). Risperidone versus haloperidol on secondary memory: Can newer medications aid learning? Schizophr. Bull. 25: 223-232.

    Google Scholar 

  • Koh, S. D., and Kayton, L. (1974). Memorization of "unrelated" word strings by young nonpsychotic individuals with schizophrenia. J. Abnorm. Psychol. 83: 14-22.

    PubMed  Google Scholar 

  • Koh, S. D., Kayton, L., and Berry, R. (1973). Mnemonic organization in young nonpsychotic individuals with schizophrenia. J. Abnorm. Psychol. 81: 299-310.

    PubMed  Google Scholar 

  • Koh, S. D., Kayton, L., and Peterson, R. A. (1976). Affective encoding and consequent remembering in schizophrenic young adults. J. Abnorm. Psychol. 85: 156-166.

    PubMed  Google Scholar 

  • Koh, S. D., Marusarz, T. Z., and Rosen, A. J. (1980). Remembering of sentences by schizophrenic young adults. J. Abnorm. Psychol. 89: 291-294.

    PubMed  Google Scholar 

  • Kolb, B., and Whishaw, I. Q. (1983). Performance of schizophrenic patients on tests sensitive to left or right frontal, temporal, or parietal function in neurological patients. J. Nerv. Ment. Dis. 171: 435-443.

    PubMed  Google Scholar 

  • Kraepelin, E. (1971). In: Dementia Praecox and Paraphrenia (p. pp17; translated by R. M. Barclay), Robertson, G. M. (ed.), R. E. Krieger Pub. Co., Huntington, NY (originally in published 1919).

    Google Scholar 

  • Kremen, W. S., Seidman, L. J., Goldstein, J. M., Faraone, S. V., and Tsuang, M. T. (1994). Systematized delusions and neuropsychological function in paranoid and nonparanoid schizophrenia. Schizophr. Res. 12: 223-236.

    PubMed  Google Scholar 

  • Kremen, W. S., Seidman, L. J., Faraone, S. V., Toomey, R., and Tsuang, M. T. (2000). The paradox of neuropsychological function in schizophrenia. J. Abnorm. Psychol. 109: 743-752.

    PubMed  Google Scholar 

  • Kremen, W. S., Seidman, L. J., Faraone, S. V., and Tsuang, M. T. (2001). Intelligence quotient and neuropsychological profiles in patients with schizophrenia and normal volunteers. Biol. Psychiatry 50: 453-462.

    PubMed  Google Scholar 

  • Landrø, N. I. (1994). Memory function in schizophrenia. Acta Psychiatr. Scand. 90(Suppl. 384): 87-94.

    Google Scholar 

  • Landrø, N. I., Ørbeck, A. L., and Rund, B. R. (1993). Memory functioning in chronic and non-chronic individuals with schizophrenia, affectively disturbed patients and normal controls. Schizophr. Res. 10: 85-92.

    PubMed  Google Scholar 

  • Langell, M. E., Purisch, A. D., and Golden, C. T. (1987). Neuropsychological differences between paranoid and non-paranoid individuals with schizophrenia on the Luria-Nebraska Battery. Int. J. Clin. Neuropsychol. 9: 88-94.

    Google Scholar 

  • Larsen, S. F., and Fromholt, P. (1976). Memory organization and free recall in schizophrenia. J. Abnorm. Psychol. 85: 61-65.

    PubMed  Google Scholar 

  • Lawrie, S. M., Whalley, H., Kestelman, J. N., Abukmeil, S. S., Byrne, M., Hodges, A., et al. (1999). Magnetic resonance imaging of brain in people at high risk of developing schizophrenia. Lancet 353: 30-33.

    PubMed  Google Scholar 

  • Levin, S., Yurgelun-Todd, D., and Craft, S. (1989). Contributions of clinical neuropsychology to the study of schizophrenia. J. Abnorm. Psychol. 98: 341-356.

    PubMed  Google Scholar 

  • Liddle, P. F. (1987). Schizophrenic syndromes, cognitive performance, and neurological dysfunction. Psychol. Med. 17: 49-57.

    PubMed  Google Scholar 

  • Lutz, J., and Marsh, T. K. (1981). The effect of a dual level word list on schizophrenic free recall. Schizophr. Bull. 7: 509-515.

    PubMed  Google Scholar 

  • Maher, B. A., Manschreck, T. C., Woods, B. T., Yurgelun-Todd, D. A., and Tsuang, M. T. (1995). Frontal brain volume and context effects in short-term recall in schizophrenia. Biol. Psychiatry 37: 144-150.

    PubMed  Google Scholar 

  • Mahurin, R. K., Velligan, D. I., and Miller, A. L. (1998). Executivefrontal lobe cognitive dysfunction in schizophrenia: A symptom subtype analysis. Psychiatry Res. 79: 139-149.

    PubMed  Google Scholar 

  • Manschreck, T. C., Maher, B. A., Milavetz, J. J., Ames, D., Weisstein, C. C., and Schneyer, M. L. (1988). Semantic priming in thought disordered schizophrenic patients. Schizophr. Res. 1: 61-66.

    PubMed  Google Scholar 

  • Martinez, J. L., and Kesner, R. P. (eds.) (1998). Neurobiology of Learning and Memory, Academic Press, New York.

    Google Scholar 

  • McCarley, R. W., Wible, C. G., Frumin, M., Hirayasu, Y., Levitt, J. L., Fischer, I. A., et al. (1999). MRI anatomy of schizophrenia. Biol. Psychiatry 45: 1099-1119.

    PubMed  Google Scholar 

  • McClain, L. (1983). Encoding and retrieval in schizophrenics' free recall. J. Nerv. Ment. Dis. 171: 471-479.

    PubMed  Google Scholar 

  • McCreadie, R. G., Latha, S., Thara, R., Padmavathi, R., and Ayankaran, J. R. (1997). Poor memory, negative symptoms and abnormalmovements in never-treated Indian patients with schizophrenia. Br. J. Psychiatry 171: 360-363.

    PubMed  Google Scholar 

  • McEnvoy, J. P., and Freter, S. (1989). The dose-response relationship for memory impairment by anticholinergic drugs. Compr. Psychiatry 30: 135-138.

    PubMed  Google Scholar 

  • McGurk, S. R. (1999). The effects of clozapine on cognitive functioning in schizophrenia. J. Clin. Psychiatry 60 (Suppl. 12): 24-29.

    PubMed  Google Scholar 

  • McKenna, P. J., Tamlyn, D., Lund, C. E., Mortimer, A. M., Hammond, S., and Baddeley, A. D. (1990). Amnestic syndrome in schizophrenia. Psychol. Med. 20: 967-972.

    PubMed  Google Scholar 

  • McNeil, T. F., Cantor-Graae, E., and Weinberger, D. R. (2000). Relationship of obstetric complications and differences in size of brain structures in monozygotic twin pairs discordant for schizophrenia. Am. J. Psychiatry 157: 203-212.

    PubMed  Google Scholar 

  • Medalia, A., Gold, J., and Merriam, A. (1988). The effects of neuroleptics on neuropsychological test results of schizophrenics. Arch. Clin. Neuropsychol. 3: 249-271.

    PubMed  Google Scholar 

  • Meltzer, H. Y., and McGurk, S. R. (1999). The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia. Schizophr. Bull. 25: 233-255.

    PubMed  Google Scholar 

  • Milner, B., Squire, L. R., and Kandel, E. R. (1998). Cognitive neuroscience and the study of memory. Neuron 20: 445-468.

    PubMed  Google Scholar 

  • Mirsky, A. F., Anthony, B. J., Duncan, C. C., Ahern, M. B., and Jellam, S. G. (1991). Analysis of the elements of attention: A neuropsychological approach. Neuropsychol. Rev. 2: 109-145.

    PubMed  Google Scholar 

  • Mishkin, M., Vargha-Khadem, F., and Gadian, D. G. (1998). Amnesia and the organization of the hippocampal system. Hippocampus 8: 212-216.

    PubMed  Google Scholar 

  • Mockler, D., Riordan, J., and Sharma, T. (1997). Memory and intellectual deficits do not decline with age in schizophrenia. Schizophr. Res. 26: 1-7.

    PubMed  Google Scholar 

  • Mohamed, S., Paulsen, J. S., O'Leary, D., Arndt, S., and Andreasen, N. (1999). Generalized cognitive deficits in schizophrenia: A study of first-episode patients. Arch. Gen. Psychiatry 56: 749-754.

    PubMed  Google Scholar 

  • Morrison-Stewart, S. L., Williamson, P. C., Corning, W. C., Kutcher, S. P., Snow, W. G., and Merskey, H. (1992). Frontal and non-frontal lobe neuropsychological test performance and clinical symptomatology in schizophrenia. Psychol. Med. 22: 353-359.

    PubMed  Google Scholar 

  • Mungas, D. (1983). Differential clinical sensitivity of specific parameters of the Rey Auditory-Verbal Learning Test. J. Consult. Clin. Psychol. 51: 848-855.

    PubMed  Google Scholar 

  • Nachmani, G., and Cohen, B. D. (1969). Recall and recognition free learning in schizophrenia. J. Abnorm. Psychol. 74: 511-516.

    PubMed  Google Scholar 

  • Nathaniel-James, J. D., Brown, R., and Ron, M. A. (1996). Memory impairment in schizophrenia: Its relationship to executive impairment. Schizophr. Res. 21: 85-96.

    PubMed  Google Scholar 

  • Nelson, M. D., Saykin, A. J., Flashman, L. A., and Riordan, H. J. (1998). Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: A meta-analytic study. Arch. Gen. Psychiatry 55: 433-440.

    PubMed  Google Scholar 

  • Nestor, P. G., Shenton, M. E., McCarley, R.W., Haimson, J., Smith, R. S., O'Donnell, B., et al. (1993). Neuropsychological correlates of MRI temporal lobe abnormalities in schizophrenia. Am. J. Psychiatry 150: 1849-1855.

    PubMed  Google Scholar 

  • Nestor, P. G., Akdag, S. J., O'Donnell, B. F. O., Niznikiewicz, M., Law, S., Shenton, M. E., et al. (1998a). Word recall in schizophrenia: A connectionist model. Am. J. Psychiatry 155: 1685-1690.

    PubMed  Google Scholar 

  • Nestor, P. G., Shenton, M. E., Wible, C., Hokama, H., O'Donnell, B. F. O., Law, S., et al. (1998b). A neuropsychological analysis of schizophrenic thought disorder. Schizophr. Res. 29: 217-225.

    PubMed  Google Scholar 

  • Newcomer, J.W., Craft, S., Fucetola, R., Moldin, S. O., Selke, G., Paras, L., et al. (1999). Glucose-induced increase in memory performance in patients with schizophrenia. Schizophr. Bull. 25: 321-335.

    PubMed  Google Scholar 

  • Nohara, S., Suzuki, M., Kurachi, M., Yamashita, I., Matsui, M., Seto, H., et al. (2000). Neural correlates of memory organization deficits in schizophrenia. A single photon emission computed tomography study with 99mTc-ethyl-cysteinate dimer during a verbal learning task. Schizophr. Res. 42: 209-222.

    Google Scholar 

  • Nopoulos, P., Flashman, L., Flaum, M., Arndt, S., and Andreasen, N. (1994). Stability of cognitive functioning early in the course of schizophrenia. Schizophr. Res. 14: 29-37.

    PubMed  Google Scholar 

  • Nuechterlein, K. H., and Dawson, M. E. (1984). Information processing and attentional functioning in the developmental course of schizophrenia. Schizophr. Bull. 10: 160-203.

    PubMed  Google Scholar 

  • O'Leary, D. S., Flaum, M., Kesler, M. L., Flashman, L. A., Arndt, S., and Andreasen, N. C. (2000). Cognitive correlates of the negative, disorganized, and psychotic symptom dimensions of schizophrenia. J. Neuropsychiatry Clin. Neurosci. 12: 4-15.

    PubMed  Google Scholar 

  • Olin, S. C., and Mednick, S. A. (1996). Risk factors of psychosis: Identifying vulnerable populations premorbidly. Schizophr. Bull. 22: 223-240.

    PubMed  Google Scholar 

  • Otto, T., and Eichenbaum, H. (1992). Toward a comprehensive account of hippocampal function: Studies of olfactory learning permit an integration of data across multiple levels of neurobiological analysis. In: Squire, L. R., and Butters, N. (eds.), Neuropsychology of Memory, Guilford Press, New York, pp. 415-428.

    Google Scholar 

  • Palmer, B. W., Heaton, R. K., Paulsen, J. S., Kuck, J., Braff, D., Harris, M. J., et al. (1997). Is it possible to be schizophrenic and neuropsychologically normal? Neuropsychology 11: 437-446.

    PubMed  Google Scholar 

  • Park, S., Holzman, P. S., and Goldman-Rakic, P. (1992). Schizophrenics show spatial working memory deficits. Arch. Gen. Psychiatry 49: 975-982.

    PubMed  Google Scholar 

  • Paulsen, J. S., Heaton, R. K., Sadek, J. R., Perry, W., Delis, D. C., Braff, D., et al. (1995). The nature of learning and memory impairments in schizophrenia. J. Int. Neuropsychol. Soc. 1: 88-99.

    PubMed  Google Scholar 

  • Pearlson, G. D., and Marsh, L. (1999). Structural brain imaging in schizophrenia: A selective review. Biol. Psychiatry 46: 627-649.

    PubMed  Google Scholar 

  • Perlick, D., Stastny, P., Katz, I., Mayer, M., and Mattis, S. (1986). Memory deficits and anticholinergic levels in chronic schizophrenia. Am. J. Psychiatry 143: 230-234.

    PubMed  Google Scholar 

  • Perlick, D., Mattis, S., Stastny, P., and Silverstein, B. (1992). Negative symptoms are related to both frontal and non-frontal neuropsychological measures in chronic schizophrenia. Arch. Gen. Psychiatry 49: 245-246.

    PubMed  Google Scholar 

  • Posner, M. I., and Petersen, S. E. (1990). The attention system of the human brain. Annu. Rev. Neurosci. 13: 25-42.

    PubMed  Google Scholar 

  • The Psychological Corporation (1997). Wechsler Adult Intelligence Scale-Third Edition. Wechsler Memory Scale-Third Edition. Technical Manual, Harcourt Brace & Company, San Antonio.

    Google Scholar 

  • Purdon, S. E., Jones, B. D. W., Stip, E., Labelle, A., Addington, D., David, S. R., et al. (2000). Neuropsychological change in early phase schizophrenia during 12 months of treatment with olanzapine, risperidone, or haloperidol. Arch. Gen. Psychiatry 57: 249-258.

    PubMed  Google Scholar 

  • Putnam, K. M., and Harvey, P. D. (1999). Memory performance of geriatric and non-geriatric chronic schizophrenic patients: A crosssectional study. J. Int. Neuropsychol. Soc. 5: 494-501.

    PubMed  Google Scholar 

  • Rapport, L. J., Axelrod, B. N., Theisen, M. E., Brines, D. B., Kalechstein, A. D., and Ricker, J. H. (1997). Relationship of IQ to verbal learning and memory: Test and retest. J. Clin. Exp. Neuropsychol. 19: 655-666.

    PubMed  Google Scholar 

  • Raven, J. C., Court, J. H., and Raven, J. (1976). Manual for Raven's Progressive Matrices, H.K. Lewis, London.

    Google Scholar 

  • Rees, S., Breen, S., Loeliger, M., McCrabb, G., and Harding, R. (1999). Hypoxemia near mid-gestation has long-term effects on fetal brain development. J. Neuropathol. Exp. Neurol. 58: 932-945.

    PubMed  Google Scholar 

  • Rison, R. A., and Stanton, P. K. (1995). Long-term potentiation and N-methyl-d-aspartate receptors: Foundations of memory and neurologic disease. Neurosci. Biobehav. Rev. 19: 533-552.

    PubMed  Google Scholar 

  • Rizzo, L., Danion, J. M., van der Linden, M., and Grange, D. (1996). Patients with schizophrenia remember that an event has occurred, but not when. Br. J. Psychiatry 168: 427-431.

    PubMed  Google Scholar 

  • Rubin, P., Holm, A., Moller-Madsen, S., Videbech, P., Hertel, C., Povlsen, U. J., et al. (1992). Neuropsychological deficit in newly diagnosed patients with schizophrenia or schizophreniform disorder. Acta Psychiatr. Scand. 92: 35-43.

    Google Scholar 

  • Rushe, T. M., Woodruff, P. W. R., Murray, R. M., and Morris, R. G. (1999). Episodic memory and learning in patients with chronic schizophrenia. Schizophr. Res. 35: 85-96.

    PubMed  Google Scholar 

  • Russell, E. W. (1987). A reference scale method for constructing neuropsychological test batteries. J. Clin. Exp. Neuropsychol. 9: 376-392.

    PubMed  Google Scholar 

  • Russell, P. N., and Beekhuis, M. E. (1976). Organization in memory: A comparison of psychotics and normals. J. Abnorm. Psychol. 85: 527-534.

    PubMed  Google Scholar 

  • Salame, P., Danion, J. M., Peretti, S., and Cuervo, C. (1998). The state of functioning of working memory in schizophrenia. Schizophr. Res. 30: 11-29.

    PubMed  Google Scholar 

  • Salmon, D. P., and Butters, N. (1995). Neurobiology of skill and habit learning. In: Squire, L. R., and Kosslyn, S. M. (eds.), Findings and Current Opinion in Cognitive Neuroscience, The MIT Press, Cambridge, MA, pp. 91-97.

    Google Scholar 

  • Sapolsky, R. M. (2000). Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch. Gen. Psychiatry 57: 925-935.

    PubMed  Google Scholar 

  • Sauer, H., Hornstein, C., Richter, P., Mortimer, A., and Hirsch, S. R. (1999). Symptom dimensions of old-age individuals with schizophrenia: Relationship to neuropsychological and motor abnormalities. Schizophr. Res. 39: 31-38.

    PubMed  Google Scholar 

  • Sautter, F. J., McDermott, B. E., Cornwell, J. M., Borges, A., Johnson, J., Vasterling, J. J., et al. (1997). A comparison of neuropsychological deficits in familial individuals with schizophrenia, nonfamilial individuals with schizophrenia, and normal controls. J. Nerv. Ment. Dis. 185: 641-644.

    PubMed  Google Scholar 

  • Saykin, A. J., Gur, R. C., Gur, R. E., Mozley, P. D., Mosley, L. H., Resnick, S. M., et al. (1991). Neuropsychological function in schizophrenia: Selective impairment in memory and learning. Arch. Gen. Psychiatry 48: 619-624.

    Google Scholar 

  • Saykin, A. J., Shtasel, D. L., Gur, R. E., Kester, D. B., Mosley, L. H., Stafiniak, M. S., et al. (1994). Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia. Arch. Gen. Psychiatry 51: 124-131.

    PubMed  Google Scholar 

  • Schacter, D. L. (1987). Memory, amnesia and frontal lobe dysfunction. Psychobiology 15: 21-36.

    Google Scholar 

  • Schacter, D. L., and Wagner, A. D. (1999). Medial temporal lobe activations in fMRI and PET studies of episodic encoding and retrieval. Hippocampus 9: 7-24.

    PubMed  Google Scholar 

  • Schmand, B., Brand, N., and Kuipers, T. (1992a). Procedural learning of cognitive and motor skills in psychotic patients. Schizophr. Res. 8: 157-170.

    PubMed  Google Scholar 

  • Schmand, B., Kop, W. J., Kuipers, T., and Bosveld, J. (1992b). Implicit learning in psychotic patients. Schizophr. Res. 7: 55-64.

    PubMed  Google Scholar 

  • Schmand, B., Kuipers, T., Van Der Gaag, M., Bosveld, J., Bulthuis, F., and Jellema, M. (1994). Cognitive disorders and negative symptoms as correlates of motivational deficits in psychotic patients. Psychol. Med. 24: 869-884.

    PubMed  Google Scholar 

  • Schröder, J., Tittel, A., Stockert, A., and Karr, M. (1996). Memory deficits in subsyndromes of chronic schizophrenia. Schizophr. Res. 21: 19-26.

    PubMed  Google Scholar 

  • Schwartz, B. L., Deutsch, L. H., Cohen, C., Warden, D., and Deutsch, S. I. (1991). Memory for temporal order in schizophrenia. Biol. Psychiatry 29: 329-339.

    PubMed  Google Scholar 

  • Schwartz, B. L., Rosse, R. B., and Deutsch, S. I. (1992). Toward a neuropsychology of memory in schizophrenia. Psychopharmacol. Bull. 28: 341-351.

    PubMed  Google Scholar 

  • Seaton, B. E., Goldstein, G., and Allen, D. N. (2001). Sources of heterogeneity in schizophrenia: The role of neuropsychological functioning. Neuropsychol. Rev. 11: 45-67.

    PubMed  Google Scholar 

  • Seidman, L. J. (1983). Schizophrenia and brain dysfunction: An integration of recent neurodiagnostic findings. Psychol. Bull. 94: 195-238.

    PubMed  Google Scholar 

  • Seidman, L. J., Cassens, G., Kremen, W. S., and Pepple, J. R. (1992). The neuropsychology of schizophrenia. In: White, R. (ed.), Clinical Syndromes in Adult Neuropsychology, The Practitioner's Handbook, Elsevier, Amsterdam, pp. 381-449.

    Google Scholar 

  • Seidman, L. J., Yurgelun-Todd, D., Kremen, W. S., Woods, B. T., Goldstein, J. M., Faraone, S. V., et al. (1994). Relationship of prefrontal and temporal lobe MRI measures to neuropsychological performance in chronic schizophrenia. Biol. Psychiatry 35: 235-246.

    PubMed  Google Scholar 

  • Seidman, L. J., Stone, W. S., Jones, R., Harrison, R. H., and Mirsky, A. F. (1998a). Comparative effects of schizophrenia and temporal lobe epilepsy on memory. J. Int. Neuropsychol. Soc. 4: 342-352.

    PubMed  Google Scholar 

  • Seidman, L. J., Stone, W. S., Sachs, W., Kalinowski, A. G., Patel, J., Schildkraut, J. J., et al. (1998b). Improvement in declarative memory in patients with chronic schizophrenia in response to clozapine: A preliminary report. Presented at the American Psychiatric Association Annual Meeting, Toronto, Canada, May 1998.

  • Seidman, L. J., Faraone, S. V., Goldstein, J. M., Goodman, J. M., Kremen, W. S., Toomey, R., et al. (1999). Thalamic and amygdala-hippocampal volume reductions in first degree relatives of schizophrenic patients: An MRI based morphometric analysis. Biol. Psychiatry 46: 941-954.

    PubMed  Google Scholar 

  • Seidman, L. J., Kremen, W. S., Koren, D., Faraone, S. V., Goldstein, J. M., and Tsuang, M. T. (2002a). A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses. Schizophr. Res. 53: 31-44.

    PubMed  Google Scholar 

  • Seidman, L. J., Faraone, S. V., Goldstein, J. M., Kremen, W. S., Horton, N. J., Makris, N., et al. (2002b). Left hippocampal volume as a vulnerability indicator for schizophrenia: An MRI morphometric study of non-psychotic first degree relatives. Arch. Gen. Psychiatry. 59: 839-849.

    PubMed  Google Scholar 

  • Sengel, R. A., and Lovallo, W. R. (1983). Effects of cueing on immediate and recent memory in individuals with schizophrenia. J. Nerv. Ment. Dis. 171: 426-430.

    PubMed  Google Scholar 

  • Shedlack, K., Lee, G., Sakuma, M., Xie, S., Kushner, M., Pepple, J., et al. (1997). Language processing and memory in ill and well siblings from multiplex families affected with schizophrenia. Schizophr. Res. 25: 43-52.

    PubMed  Google Scholar 

  • Shelley, A. M., Ward, P. B., Catts, S. V., Michie, P. T., Andrews, S., and McConaghy, N. (1991). Mismatch negativity, an index of a preattentive processing deficit in schizophrenia. Biol. Psychiatry 30: 1059-1062.

    PubMed  Google Scholar 

  • Shenton, M. E., Kikinis, R., Jolesz, F. A., Pollak, S. D., LeMay, M., Wible, C. G., et al. (1992). Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N. Engl. J. Med. 327: 604-612.

    PubMed  Google Scholar 

  • Shimamura, A. P. (1995). Memory and frontal lobe function. In: Gazzaniga, M. S. (ed.), The Cognitive Neurosciences, MIT Press, Cambridge, MA, pp. 803-813.

    Google Scholar 

  • Silver, H., and Geraisy, N. (1995). Effects of Biperiden and Amantadine on memory in medicated chronic schizophrenic patients. A double-blind cross-over study. Br. J. Psychiatry 166: 241-243.

    PubMed  Google Scholar 

  • Silverstein, M. L., Schwartz, M. L., and Rennick, P. M. (1973). Recall of verbal material in temporal lobe epilepsy and memory. Dis. Nerv. Syst. 34: 234-240.

    PubMed  Google Scholar 

  • Silverstein, M. L., McDonald, C., and Meltzer, H. Y. (1988). Differential patterns of neuropsychological deficit in psychiatric disorders. J. Clin. Psychol. 44: 412-415.

    PubMed  Google Scholar 

  • Speed, M., Toner, B. B., Shugar, G., and Di Gasbarro, I. (1991). Thought disorder and verbal recall in acutely psychotic patients. J. Clin. Psychol. 47: 736-744.

    Google Scholar 

  • Spitzer, M., Braun, U., Hermle, L., and Maier, S. (1993). Associative semantic network dysfunction in thought-disordered schizophrenic patients: Direct evidence from indirect semantic priming. Biol. Psychiatry 34: 864-877.

    PubMed  Google Scholar 

  • Squire, L. R., and Kandel, E. R. (1999). Memory: >From Mind to Molecules, Scientific American Library, New York.

    Google Scholar 

  • Squire, L. R., and Zola, S. M. (1998). Episodic memory, semantic memory, and amnesia. Hippocampus 8: 205-211.

    PubMed  Google Scholar 

  • Squire, L. R., Cohen, N. J., and Nadel, L. (1984). The medial temporal region and memory consolidation: A new hypothesis. In: Eingartner, H., and Parker, E. (eds.), Memory Consolidation, Erlbaum, Hillsdale, NJ, pp. 185-210.

    Google Scholar 

  • Stefanis, N., Frangou, S., Yakeley, J., Sharma, T., O'Connell, P., Morgan, K., et al. (1999). Hippocampal volume reduction in schizophrenia: Effects of genetic risk and pregnancy and birth complications. Biol. Psychiatry 46: 697-702.

    PubMed  Google Scholar 

  • Stein, R. A., and Strickland, T. L. (1998). A review of the neuropsychological effects of commonly used prescription medication. Arch. Clin. Neuropsychol. 13: 259-284.

    PubMed  Google Scholar 

  • Stip, E., and Lussier, I. (1996). The effect of risperidone on cognition in patients with schizophrenia. Can. J. Psychiatry 41 (Suppl. 2): S35-S40.

    PubMed  Google Scholar 

  • Stirling, J. D., Hellewell, J. S. E., and Hewitt, J. (1997). Verbal memory impairment in schizophrenia: No sparing of short-term recall. Schizophr. Res. 25: 85-95.

    PubMed  Google Scholar 

  • Stolar, N., Berenbaum, H., Banich, M. T., and Barch, D. (1994). Neuropsychological correlates of alogia and affective flattening in schizophrenia. Biological Psychiatry 35: 164-172.

    PubMed  Google Scholar 

  • Stone, M., Gabrieli, J. D. E., Stebbins, G. T., and Sullivan, E. V. (1999a). Working and strategic memory deficits in schizophrenia. Neuropsychology 12: 278-288.

    Google Scholar 

  • Stone, W. S., Seidman, L. J., Wojcik, J., and Green, A. I. (1999b). Glucose effects in schizophrenia. Poster presented at the annual meeting of the Society for Neuroscience, abstract number 830.4, Vol. 25, p. 2074.

    Google Scholar 

  • Suddath, R. L., Christison, G. W., Torrey, E. F., Casanova, M. F., and Weinberger, D. R. (1990). Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N. Engl. J. Med. 322: 789-794.

    PubMed  Google Scholar 

  • Sullivan, E. V., Shear, P. K., Zipursky, R. B., Sagar, H. J., and Pfefferbaum, A. (1994). A deficit profile of executive, memory, and motor functions in schizophrenia. Biol. Psychiatry 36: 641-653.

    PubMed  Google Scholar 

  • Sweeney, J. A., Haas, G. L., Keilp, J. G., and Long, M. (1991). Evaluation of the stability of neuropsychological functioning after acute episodes of schizophrenia: One-year follow-up study. Psychiatry Res. 38: 63-76.

    PubMed  Google Scholar 

  • Tamlyn, D., McKenna, P. J., Mortimer, A. M., Lund, C. E., Hammond, S., and Baddeley, A. D. (1992). Memory impairment in schizophrenia: Its extent affiliations and neuropsychological character. Psychol. Med. 22: 101-115.

    PubMed  Google Scholar 

  • Tiplady, B., Harding, C., McLean, D., Ortner, C., Porter, K., and Wright, P. (1999). Effects of ethanol and temazepam on episodic and semantic memory:Adose-response comparison. Hum. Psychopharmacol. 14: 263-269.

    Google Scholar 

  • Toomey, R., Kremen, W. S., Simpson, J. C., Samson, J. A., Seidman, L. J., Lyons, M. J., et al. (1997). Revisiting the factor structure for positive and negative symptoms: Evidence from a large heterogeneous group of psychiatric patients. Am. J. Psychiatry 154: 371-377.

    PubMed  Google Scholar 

  • Traupmann, K. L. (1975). Effects of categorization and imagery on recognition and recall by process and reactive individuals with schizophrenia. J. Abnorm. Psychol. 84: 307-314.

    PubMed  Google Scholar 

  • Traupmann, K. L. (1980). Encoding processes and memory for categorically related words by schizophrenic patients. J. Abnorm. Psychol. 89: 704-716.

    PubMed  Google Scholar 

  • Tsuang, M. T. (1982). Memory deficit and long-term outcome in schizophrenia: A preliminary study. Psychiatry Res. 6: 355-360.

    PubMed  Google Scholar 

  • Tsuang, M. T., Stone, W. S., and Faraone, S. V. (1999). Schizophrenia: A review of genetic studies. Harv. Rev. Psychiatry 7: 185-207.

    PubMed  Google Scholar 

  • Tulving, E. (1962). Subjective organization in free recall of "unrelated" words. Psychol. Rev. 69: 344-354.

    PubMed  Google Scholar 

  • Tulving, E., and Markowitsch, H. J. (1998). Episodic and declarative memory: Role of the hippocampus. Hippocampus 8: 198-204.

    PubMed  Google Scholar 

  • Tune, L. E., Strauss, M. E., Lew, M. F., Breitlinger, E., and Coyle, J. T. (1982). Serum levels of anticholinergic drugs and impaired recent memory in chronic schizophrenic patients. Am. J. Psychiatry 139: 1460-1465.

    PubMed  Google Scholar 

  • Vargha-Khadem, F., Gadian, D. G., Watkins, K. E., Conneley, A., Van Paesschen, W., and Mishkin, M. (1997). Differential aspects of early hippocampal pathology on episodic and semantic memory. Science 277: 376-380.

    PubMed  Google Scholar 

  • Vinogradov, S., Willis-Shore, J., Poole, J. H., Marten, E., Ober, B. A., and Shenaut, G. K. (1997). Clinical and neurocognitive aspects of source monitoring errors in schizophrenia. Am. J. Psychiatry 154: 1530-1537.

    PubMed  Google Scholar 

  • Wagner, A. D. (1999). Working memory contributions to human learning and remembering. Neuron 22: 19-22.

    PubMed  Google Scholar 

  • Wagner, A. D., Schacter, D. L., Rotte, M., Koutstaal, W., Maril, A., Dale, A., et al. (1998). Building memories: Remembering and forgetting of verbal experiences as predicted by brain activity. Science 281: 1188-1191.

    PubMed  Google Scholar 

  • Wechsler, D. (1955). WAIS Manual, The Psychological Corporation, New York.

    Google Scholar 

  • Wechsler, D. (1981). WAIS-R Manual, The Psychological Corporation, New York.

    Google Scholar 

  • Weinberger, D. R. (1999). Cell biology of the hippocampal formation in schizophrenia. Biol. Psychiatry 45: 395-402.

    PubMed  Google Scholar 

  • Weinberger, D. R., Berman, K. F., Suddath, R., and Torrey, E. F. (1992). Evidence of dysfunction of a prefrontal-limbic network in schizophrenia. Am. J. Psychiatry 149: 890-897.

    PubMed  Google Scholar 

  • Wheeler, M. A., Stuss, D.T., and Tulving, E. (1995). Frontal lobe damage produces episodic memory impairment. J. Int. Neuropsychol. Soc. 1: 525-536.

    PubMed  Google Scholar 

  • Wright, I. C., Rabe-Hesketh, S., Woodruff, P.W. R., David, A. S., Murray, R. M., and Bullmore, E. T. (2000). Meta-analysis of regional brain volumes in schizophrenia. Am. J. Psychiatry 157: 16-25.

    PubMed  Google Scholar 

  • Yesavage, J. A., Portnoff, L. A., and Rode, T. L. (1983). Auditory versus memory deficits in paranoid and chronic undifferentiated individuals with schizophrenia. J. Psychiatr. Treat. Eval. 5: 309-314.

    Google Scholar 

  • Zakzanis, K. K. (1998). Neuropsychological correlates of positive vs. negative schizophrenic symptomatology. Schizophr. Res. 29: 227-233.

    Google Scholar 

  • Zihl, J., Gron, G., and Brunnauer, A. (1998). Cognitive deficits in schizophrenia and affective disorders: Evidence for a final common pathway disorder. Acta Psychiatr. Scand. 97: 351-357.

    PubMed  Google Scholar 

  • Zornberg, G. L., Buka, S. L., and Tsuang, M. T. (2000). Hypoxic-ischemia-related fetal/neonatal complications and risk of schizophrenia and other nonaffective psychoses: A 19-year longitudinal study. J. Abnorm. Psychol. 157: 196-202.

    Google Scholar 

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    Michael A. Cirillo & Larry J. Seidman

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Cirillo, M.A., Seidman, L.J. Verbal Declarative Memory Dysfunction in Schizophrenia: From Clinical Assessment to Genetics and Brain Mechanisms. Neuropsychol Rev 13, 43–77 (2003). https://doi.org/10.1023/A:1023870821631

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