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Identification of chromosome rearrangements between the laboratory mouse (Mus musculus) and the Indian spiny mouse (Mus platythrix) by comparative FISH analysis

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Abstract

Comparative chromosome painting was applied to the Indian spiny mouse (Mus platythrix) with mouse (M. musculus) chromosome-specific probes for understanding the process of chromosome rearrangements between the two species. The chromosome locations of the 5S and 18S-28S ribosomal RNA genes and the order of the 119 and Tcp-1 genes in the In(17)2 region of the t-complex were also compared. All the painting probes were successfully hybridized to the Indian spiny mouse chromosomes, and a total of 27 segments homologous to mouse chromosomes were identified. The comparative FISH analysis revealed that tandem fusions were major events in the chromosome evolution of the Indian spiny mouse. In addition, other types of chromosome rearrangements, i.e. reciprocal translocations and insertions, were also included.

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Authors and Affiliations

  1. Laboratory of Cytogenetics, Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University, North 10 West 8, Kita-ku, Sapporo, 060-0810, Japan

    Kazumi Matsubara, Chizuko Nishida-Umehara & Yoichi Matsuda

  2. Laboratory of Animal Cytogenetics, Center for Advanced Science and Technology, Hokkaido University, North 10 West 8, Kita-ku, Sapporo, 060-0810, Japan

    Chizuko Nishida-Umehara, Asato Kuroiwa & Yoichi Matsuda

  3. Chromosome Research Unit, Faculty of Science, Hokkaido University, North 10 West 8, Kita-ku, Sapporo, 060-0810, Japan

    Chizuko Nishida-Umehara & Yoichi Matsuda

  4. Laboratory of Wild Animals, Department of Zootechnical Sciences, Faculty of Agriculture, Tokyo University of Agriculture, 1737 Funako, Atsugi, Kanagawa, 234-0034, Japan

    Kimiyuki Tsuchiya

Authors
  1. Kazumi Matsubara
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  2. Chizuko Nishida-Umehara
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  3. Asato Kuroiwa
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  4. Kimiyuki Tsuchiya
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  5. Yoichi Matsuda
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Matsubara, K., Nishida-Umehara, C., Kuroiwa, A. et al. Identification of chromosome rearrangements between the laboratory mouse (Mus musculus) and the Indian spiny mouse (Mus platythrix) by comparative FISH analysis. Chromosome Res 11, 57–64 (2003). https://doi.org/10.1023/A:1022010116287

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