Digestive Diseases and Sciences

, Volume 48, Issue 1, pp 140–145

Intensive Interferon Therapy Does Not Increase Virological Response Rates in African Americans with Chronic Hepatitis C

  • Dickens Theodore
  • Mitchell L. Shiffman
  • Richard K. Sterling
  • Christine J. Bruno
  • Jeffrey Weinstein
  • Jeffrey S. Crippin
  • Gabriel Garcia
  • Teresa L. Wright
  • Hari Conjeevaram
  • Rajender K. Reddy
  • Frederick S. Nolte
  • Michael W. Fried
Article

DOI: 10.1023/A:1021750818611

Cite this article as:
Theodore, D., Shiffman, M.L., Sterling, R.K. et al. Dig Dis Sci (2003) 48: 140. doi:10.1023/A:1021750818611

Abstract

To determine if an intensive regimen of daily, high-dose interferon would improve the initial response rates to therapy for hepatitis C genotype 1 among African American and Caucasian patients, we conducted a retrospective analysis of a treatment trial conducted between October 1995 and June 1997. Patients were randomized to 24 weeks of therapy with interferon −α-2b at either 5 MU daily or 3 MU three times a week. On the standard interferon regimen (3 MU three times a week) African Americans and Caucasians had similar initial response rates. However, unlike Caucasians, African Americans did not have an increased initial virological response when treated with an intensive, daily dose regimen. Levels of HCV RNA decreased more slowly during the first 12 weeks of therapy among African Americans. Nelson-Aalen cumulative hazard estimates for the different race and dose combinations revealed that Caucasians who received daily interferon were most likely to have an initial response (logrank, P < 0.001).

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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • Dickens Theodore
    • 1
  • Mitchell L. Shiffman
    • 2
  • Richard K. Sterling
    • 2
  • Christine J. Bruno
    • 3
  • Jeffrey Weinstein
    • 4
  • Jeffrey S. Crippin
    • 4
  • Gabriel Garcia
    • 5
  • Teresa L. Wright
    • 6
  • Hari Conjeevaram
    • 7
  • Rajender K. Reddy
    • 8
  • Frederick S. Nolte
    • 3
  • Michael W. Fried
    • 1
  1. 1.University of North Carolina at Chapel HillNorth Carolina
  2. 2.Medical College of VirginiaVirginia
  3. 3.Emory UniversityAtlantaGeorgia
  4. 4.Baylor UniversityDallasTexas
  5. 5.Stanford UniversityPalo AltoCalifornia
  6. 6.University of CaliforniaSan FranciscoCalifornia
  7. 7.University of MichiganMichigan
  8. 8.University of MiamiFloridaUSA