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The Influence of Free Fatty Acid Formation on the pH of Phospholipid-Stabilized Triglyceride Emulsions

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REFERENCES

  1. P. K. Hansrani, S. S. Davis, and M. J. Groves. The preparation and properties of sterile intravenous emulsions. J. Parent. Sci. Technol. 37:145–150 (1983).

    Google Scholar 

  2. I. Håkansson. Physico-chemical changes in artificial fat emulsions during storage. Acta Chem. Scand. 20:2267–2281 (1966).

    Google Scholar 

  3. C. J. Herman. The Influence of Thermal Stress on the Properties of Phospholipid Stabilized Emulsions, Ph.D. thesis, University of Illinois at Chicago, Chicago, 1992.

  4. C. Washington and S. S. Davis. Ageing effects in parenteral fat emulsions: The role of fatty acids. Int. J. Pharm. 39:33–37 (1987).

    Google Scholar 

  5. J. M. A. Kemps and D. J. A. Crommelin. Chemical stability of phospholipids in pharmaceutical preparations: Hydrolysis of phospholipids in an aqueous medium. Pharm. Weekblad. 123:355–363 (1988).

    Google Scholar 

  6. C. J. Herman and M. J. Groves. Hydrolysis kinetics of phospholipids in thermally stressed intravenous lipid emulsion formulations. J. Pharm. Pharmacol. 44:539–542 (1992).

    Google Scholar 

  7. M. Grit, J. H. de Smidt, A. Struijke, and D. J. A. Crommelin. Hydrolysis of phosphatidylcholine in aqueous liposome dispersions. Int. J. Pharm. 50:1–6 (1989).

    Google Scholar 

  8. D. M. Lidgate, R. C. Fu, and J. S. Fleitman. Using a microfluidizer to manufacture emulsions. BioPharm. 45:28–33 (1989).

    Google Scholar 

  9. G. Lee, D. Dick, E. V. Vasquez, and K. Werner. pH measurements of suspensions. In M. H. Rubenstein (ed.), Pharmaceutical Technology: Drug Stability, Ellis Horwood, Chichester, UK, pp. 113–117.

  10. C. Paquot. Determination of the acid value and the acidity. In Standard Methods for the Analysis of Oils, Fat, and Derivatives, Pergamon, New York, 1979, pp. 52–55.

    Google Scholar 

  11. P. W. Atkins. Physical Chemistry, W. H. Freeman, New York, 1986.

    Google Scholar 

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Herman, C.J., Groves, M.J. The Influence of Free Fatty Acid Formation on the pH of Phospholipid-Stabilized Triglyceride Emulsions. Pharm Res 10, 774–776 (1993). https://doi.org/10.1023/A:1018932421357

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  • DOI: https://doi.org/10.1023/A:1018932421357

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