Digestive Diseases and Sciences

, Volume 43, Issue 9, pp 1946–1950

Assessment of Intestinal Permeability with a Two-Hour Urine Collection


  • Sharmeen Akram
  • Samir Mourani
  • Ching-Nan Ou
  • Cheryl Rognerud
  • Raheela Sadiq
  • Richard W. Goodgame

DOI: 10.1023/A:1018826307489

Cite this article as:
Akram, S., Mourani, S., Ou, C. et al. Dig Dis Sci (1998) 43: 1946. doi:10.1023/A:1018826307489


The differential urinary excretion of orally administered lactulose and mannitol is used to evaluate intestinal permeability. This test usually involves a 5- to 6-hr urine collection. We hypothesized that a shorter collection time would give an equivalent result. Forty-three patients with a variety of gastrointestinal symptoms and diagnoses (group 1) and 42 patients with Crohn's disease (group 2) had a standard lactulose/mannitol permeability test. The lactulose and mannitol urinary excretion was calculated using the first urine (group 1) or the 1-hr and 2-hr urine (group 2) and was compared to the values calculated from the routine 5- or 6-hr collection. Lactulose excretion kinetics, expressed as the percent of the total urinary excretion within a given time period, were as follows: 21% in first hour (group 2), 29% in second hour (group 2), and 46% in first 2.5 hr (group 1). Mannitol urinary excretion kinetics were 16%, 31%, and 44%, respectively. The lactulose/mannitol ratio based on a standard urine collection correlated well with the ratio based on just the first urine produced by the patient (R2 = 0.94; P < 0.001; group 1) and the 2-hr urine (R2 = 0.464; P < 0.001; group 2). Future use of the lactulose/mannitol ratio to assess intestinal permeability may be able to be simplified by shortening the urine collection time.


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© Plenum Publishing Corporation 1998