Pharmaceutical Research

, Volume 6, Issue 9, pp 743–747

Ion Pair Transport Across Membranes


  • Reinhard Neubert
    • Sektion Pharmazie derMartin-Luther-Universität

DOI: 10.1023/A:1015963128124

Cite this article as:
Neubert, R. Pharm Res (1989) 6: 743. doi:10.1023/A:1015963128124


The present review discusses drugs and counter ions suitable for ion pair transport (IPT). Ion pairing is shown to effectively increase the lipophilicity and transport rate of polar drugs across lipid membranes. The proposed mechanisms of IPT are discussed in detail. A marked change in drug properties upon ion pair formation is necessary to improve the bioavailability of hydrophilic ionizable drugs.

ion pair transport (IPT)mechanism of IPThydrophilic drugscounter ionseffects on pharmacokinetics

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© Plenum Publishing Corporation 1989