Apoptosis

, Volume 5, Issue 5, pp 415–418

Role of reactive oxygen species (ROS) in apoptosis induction

  • H.-U. Simon
  • A. Haj-Yehia
  • F. Levi-Schaffer
Article

DOI: 10.1023/A:1009616228304

Cite this article as:
Simon, HU., Haj-Yehia, A. & Levi-Schaffer, F. Apoptosis (2000) 5: 415. doi:10.1023/A:1009616228304

Abstract

Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.

apoptosisdeath receptorsinflammationreactive oxygen species (ROS)

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • H.-U. Simon
    • 1
  • A. Haj-Yehia
    • 2
  • F. Levi-Schaffer
    • 2
  1. 1.Department of PharmacologyUniversity of BernBernSwitzerland
  2. 2.Department of Pharmaceutics, School of PharmacyThe Hebrew University-Hadassah Medical SchoolJerusalemIsrael