Role of reactive oxygen species (ROS) in apoptosis induction
- Cite this article as:
- Simon, HU., Haj-Yehia, A. & Levi-Schaffer, F. Apoptosis (2000) 5: 415. doi:10.1023/A:1009616228304
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Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.