Article

Apoptosis

, Volume 5, Issue 5, pp 415-418

Role of reactive oxygen species (ROS) in apoptosis induction

  • H.-U. SimonAffiliated withDepartment of Pharmacology, University of Bern
  • , A. Haj-YehiaAffiliated withDepartment of Pharmaceutics, School of Pharmacy, The Hebrew University-Hadassah Medical School
  • , F. Levi-SchafferAffiliated withDepartment of Pharmaceutics, School of Pharmacy, The Hebrew University-Hadassah Medical School

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Abstract

Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.

apoptosis death receptors inflammation reactive oxygen species (ROS)