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A review of zygomycosis due to Basidiobolus ranarum

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Abstract

Zygomycosis due to Basidiobolus ranarum (entomophthoromycosis basidiobolae, subcutaneous zygomycosis, subcutaneous phycomycosis, basidiobolomycosis) is a granulomatous infection of the skin and subcutaneous tissues characterized by the formation of fluctuant firm and non-tender swellings, generally on the extremities, trunk and rarely other parts of the body. The causative agent is common in soil, decaying vegetable matter, and the gastrointestinal tracts of amphibians, reptiles, fish and bats. It is presumed that infection is acquired through exposure to B. ranarum following minor trauma to skin or insect bites. The disease usually occurs in children, less often in adolescents and rarely in adults. Males are much more frequently affected than females. Laboratory diagnosis is based on histopathology and culture. The typical histopathological feature is the presence of thin-walled, broad often aseptate hyphae or hyphal fragments with an eosinophilic sheath, frequently phagocytized within giant cells. Basidiobolus ranarum is known to produce several enzymes, e.g. lipase and protease that probably play roles in the pathogenesis of infections caused by this mould. An immunological test has been developed for specific diagnosis of the disease. Though potassium iodide (KI) has been the traditional drug employed in the treatment of infections by B. ranarum, several other drugs, viz amphotericin B, cotrimoxazole, ketoconazole, itraconazole and fluconazole have been successfully tried.

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References

  1. Joe LK, Eng NIT, Pohan A, Van Der Muillen H, Emmons CW. Basidiobolus ranarum as a cause of subcutaneous mycosis in Indonesia. Arch Dermatol 1956; 74: 378–383.

    Google Scholar 

  2. Joe LK, Harsono T, Rukmonon, Eng NIT. Subcutaneous phycomycosis in man: Description of three new cases. Trop Med Hyg 1962; 65: 38–42.

    Google Scholar 

  3. Rippon JW. Medical Mycology: The pathogenic fungi and actinomycetes, 3rd edn, Philadelphia: WB Saunders Co., 1988: 681–713.

    Google Scholar 

  4. Kwon-Chung KJ, Bennet JE. Medical mycology. Philadelphia: Lea & Febiger, 1992: 447–463.

    Google Scholar 

  5. Burkitt DP, Wilson AMM, Jelliffe DB. Subcutaneous phycomycosis: A review of 31 cases seen in Uganda. Br Med J 1964; 1: 1669–1672.

    Google Scholar 

  6. Mugerwa JW. Entomophthoromycosis caused by Basidiobolus haptosporus. In: Waren KS, Mahmoud AF (eds), Tropical and geographic medicine. New York: McGraw-Hill, 1984: 968–970.

    Google Scholar 

  7. Clark BM. Epidemiology of subcutaneous phycomycosis: A Ciba Foundation Symposium. In: Wolsteinhome GEW, Porter R (eds), Systemic mycoses. London: J & A Churchill Ltd., 1968: 179–192.

    Google Scholar 

  8. Atonelli M, Vignetti P, Dahir M, Mohammed M, Favah AA. Entomophthoromycosis due to Basidiobolus in Somalia. Trans Roy Trop Med Hyg 1987; 81: 186–187.

    Google Scholar 

  9. Kelly S, Gill N, Hutt MSR. Subcutaneous phycomycosis in Sierra Leone. Trans Roy Trop Med Hyg 1980; 74: 396–397.

    Google Scholar 

  10. Vismer HF, DeBeer HA, Dreyer L. Subcutaneous phycomycosis caused by Basidiobolus haptosporus (Drechsler, 1947). S Afr Med J 1980; 58: 644–647.

    Google Scholar 

  11. Koshi G, Kurien T, Sundarsnam D, Selvapandian AJ, Mamen KE. Subcutaneous phycomycosis caused by Basidiobolus: Report of three cases. Sabouraudia 1972; 10: 237–247.

    Google Scholar 

  12. Thasnakorn P, Sriboonma V, Chantrkul N, Bhadrakom S. Subcutaneous phycomycosis due to Basidiobolus meristosporus: Report of a case. J Med Assoc Thai 1969; 53: 372–377.

    Google Scholar 

  13. Bittencourt Al, Londero AT, Aranjo MDG, Medenea N, Bastos JLA. Occurrence of subcutaneous Zygomycosis caused by Basidiobolus haptosporus in Brazil. Mycopathologia 1979; 62: 101–104.

    Google Scholar 

  14. Coremans-Pelsneer J. Isolation of Basidiobolus meristosporus from natural sources. Mycopath Mycol Appl 1973; 49: 173–176.

    Google Scholar 

  15. Gugnani HC, Okafor JI. Mycotic flora of the intestine and other internal organs of certain reptiles and amphibians with special reference to characterization of Basidiobolus isolates. Mycosen 1980; 23: 260–268.

    Google Scholar 

  16. Okafor JI, TeStrake D, Mushinsky HR, Yangco BG. A Basidiobolus sp. and its association with reptiles and amphibians in Southern Florida. Sabouraudia: J Med Vet Mycol 1984; 22: 47–51.

    Google Scholar 

  17. Okafor JI. Taxonomy, ecology and physiology of Basidiobolus species and Conidiobolus coronatus. Ph.D. Thesis, 1984, University of Nigeria, Nsukka, Nigeria.

    Google Scholar 

  18. Drechsler C. A southern Basidiobolus forming many sporangia from globose and from elongated conidia. J Wash Acad Sci 147; 74: 403–414.

  19. Chaturvedi VP, Randhawa HS, Khan ZU, Singh N, Kini S. Prevalence of Basidiobolus ranarum Eidam in intestinal tract of an insectivorous bat, Rhinopoma hardwickei hardwickei Gray in Delhi. Sabouraudia: J Med Vet Mycol 1984; 22: 185–189.

    Google Scholar 

  20. Spear S, Thomas AD. Kangaroos and wallabies as carriers of Basidiobolus haptosporus. Aust Vet J 1988; 62: 209–210.

    Google Scholar 

  21. Kamalam A, Thambiah AS. Muscle invasion by Basidiobolus haptosporus. Sabouraudia: J Med Vet Mycol 1982; 22: 273–277.

    Google Scholar 

  22. Kamalam A, Thambiah AS. Lymphoedema and elephantiasis in basidiobolosis. Mykosen 1982; 22: 508–511.

    Google Scholar 

  23. Bittencourt A, Sera G, Sadigarsky M, Araujo M, Campos MCS, et al. Subcutaneous Zygomycosis caused by Basidiobolus haptosporus. Presentation of a case mimicking Burkittt's lymphoma. Am J Trop Med Hyg 1982; 31: 370–373.

    Google Scholar 

  24. Dworzack DI, Pollack AS, Hodges GR, Barnes WG, Ajello L, Padhye AA. Zygomycosis of maxillary sinus and palate caused by Basidiobolus haptosporus. Arch Intern Med 1978; 138: 1274–1276.

    Google Scholar 

  25. Onuigbo WIB, Gugnani HC. Deep mycoses prevalent in the Igbos of Nigeria. Int J Dermatol 1976; 15: 432–437.

    Google Scholar 

  26. Bittencourt AJ, Ayala MAR, Ramos EAG. A new form of abdominal zygomycosis different from mucormycosis: Report of two cases and a review of the literature. Am J Trop Med Hyg 1979; 28: 564–569.

    Google Scholar 

  27. de Aguiar E, Moraes WC, Londero AT. Gastrointestinal entomophthoromycosis caused by Basidiobolus haptosporus. Mycopathologia 1980; 72: 101–105.

    Google Scholar 

  28. Schmidt JH, Howard RJ, Chen JL, Pierson K. First culture-proven gastrointestinal entomophthoromycosis in the United States. A case report and review of literature. Mycopathologia 1986; 95: 101–104.

    Google Scholar 

  29. Pasha TM, Leighton JA, Smilack JD, Heppel J, Colby TV, Kaufman L. Basidiobolomycosis: An unusual fungal infection mimicking inflammatory bowel disease. Gastroenterology 1997; 112: 250–254.

    Google Scholar 

  30. Nazir Z, Hasan R, Pervaiz S, Alam M, Moazam F. Invasive retroperitoneal infection due to Basidiobolus ranarum with response to potassium iodide-case report and review of literature. Ann Trop Paed 1997; 17: 161–164.

    Google Scholar 

  31. Khan ZU, Prakesh B, Kapoor MM, Modda JP, Chandy R. Basidiobolomycosis of the rectum masquerading as Crohn's disease: Case report and review. Clin Infect Dis 1998; 26: 521–523.

    Google Scholar 

  32. Bittenocourt M, Araujo MDGS, Paes M, Do SF. Occurrence of subcutaneous zygomycosis (entomophthoromycosis basidiobolae) caused by Basidiobolus haptosporus with pulmonary involvement. Mycopathologia 1980; 71: 155–158.

    Google Scholar 

  33. Edington GM. Phycomycosis in Ibadan, Western Nigeria: Two postmortem cases. Trans Roy Med Hyg 1964; 58: 242–245.

    Google Scholar 

  34. Miller RI, Campbell RSF. The comparative pathology of equine cutaneous phycomycosis. Vet Pathol 1984; 21: 325–332.

    Google Scholar 

  35. Owen WR, Miller RI, Haynes PF, Snider TG. III Phycomycosis caused by Basidiobolus haptosporus in two horses. J Am Vet Med Ass 1984; 186: 703–705.

    Google Scholar 

  36. Groff JM, Mughannam A, McDowell TS, Wong A, Dykstra MJ, Frye FL, Hedrick RP. An epizootic of cutaneous zygomycosis dwarf African clawed frogs (Hymenochris curtipes) due to Basidiobolus ranarum. J Med Vet Mycol 1991; 29: 215–253.

    Google Scholar 

  37. Yang BY. Basidiobolus meristosporus of Taiwan. Taiwania 1962; 8: 17–27.

    Google Scholar 

  38. Eades SM, Corbel MJ. Experimental cerebral lesions produced by inoculation with Basidiobolus strains. Mycopathologia 1979; 67: 187–192.

    Google Scholar 

  39. Goodman L, Rinaldi MG. Agents of zygomycosis. In: Balows A, Hausler Jr WI, Hermann Kl, et al. (eds), Manual of clinical microbiology, 5th edn. Washington DC: American Society for Microbiology, 1991: 674–692.

    Google Scholar 

  40. McGinnis MR. Recent developments and changes in medical mycology. Ann Rev Microbiol 1980; 34: 109–135.

    Google Scholar 

  41. Williams AO. Pathology of phycomycosis due to Entomophthora and Basidiobolus species. Arch Path 1969; 37: 13–20.

    Google Scholar 

  42. Shipton WA, Zahari P. Sporulation media for Basidiobolus species. J Med Vet Mycol 1987; 25: 323–327.

    Google Scholar 

  43. Echetebu CO, Ononogbu JC. Extracellular lipase and proteinase of Basidiobolus haptosporus: Possible role in subcutaneous mycosis. Mycopathologia 1982; 80: 171–177.

    Google Scholar 

  44. Okafor JI, Gugnani HC, TeStrake D, Yangco BG. Extracellular enzyme activities of Basidiobolus and Conidiobolus species. Mycoses 1987; 30: 404–407.

    Google Scholar 

  45. Okafor JI, Gugnani HC. Lipase activities of Basidiobolus and Conidiobolus species. Mycoses 1990; 33: 81–85.

    Google Scholar 

  46. Okafor JI. Purification and characterization of protease enzymes of Basidiobolus and Conidiobolus species. Mycoses 1994; 37: 265–269.

    Google Scholar 

  47. Yangco BG, Nettlow A, Okafor JI, Park J, TeStrake D. Comparative antigenic studies of species of Basidiobolus and other medically important fungi. J Clin Microbiol 1986; 23: 679–682.

    Google Scholar 

  48. Kaufman L, Mendoza L, Standard PG. Immunodiffusion test for serodiagnosing subcutaneous zygomycosis. J Clin Microbiol 1990; 28: 1887–1890.

    Google Scholar 

  49. Kamalam A, Thambia AS. Entomophthtorae basidiobolae successfully treated with KI. Mykoen 1979; 22: 82–84.

    Google Scholar 

  50. Fomufod AR, Antia AO. Successful treatment of subcutaneous phycomycosis with trimenhoprim-sulfamentoxazole (septrin). Trop Georg Med 1971; 23: 208–211.

    Google Scholar 

  51. Yangco BG, Okafor JI, TesStrake D. In vitro susceptibilities of human and wild-type isolates of Basidiobolus and Conidiobolus species. Antimicrob Agents Chemother 1984; 25: 413–416.

    Google Scholar 

  52. Van Cutsem J, Van Gerven F, Janssen PAJ. Activity of orally and parentally administered itraconazole in the treatment of superficial and deep mycoses: Animal models. Rev Infect Dis 1987; 9(Suppl 1): 515–532.

    Google Scholar 

  53. Randhawa HS, Budimulja U, Bazaz-Malik G, Bramono K, Hiruma M, Kullavanijaya P, Rohjanavanich V. Recent developments in the diagnosis and treatment of subcutaneous mycoses. J Med Vet Mycol 1994; 32(Suppl 1): 229–307.

    Google Scholar 

  54. Gugnani HC, Ezenolue BC, Khalil M, Amoha CD, Ajulu EU, Oyewo EA. Fluconazole in the therapy of tropical deep mycoses. Mycoses 1995; 38: 485–488.

    Google Scholar 

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  1. Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India

    H.C. Gugnani

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Gugnani, H. A review of zygomycosis due to Basidiobolus ranarum. Eur J Epidemiol 15, 923–929 (1999). https://doi.org/10.1023/A:1007656818038

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