Origins of life and evolution of the biosphere

, Volume 28, Issue 4, pp 501–514

Graded Autocatalysis Replication Domain (GARD): Kinetic Analysis of Self-Replication in Mutually Catalytic Sets

Authors

  • Daniel Segré
    • Department of Membrane Research and BiophysicsThe Weizmann Institute of Science
  • Doron Lancet*
    • Department of Membrane Research and BiophysicsThe Weizmann Institute of Science
  • Ora Kedem
    • Department of Membrane Research and BiophysicsThe Weizmann Institute of Science
  • Yitzhak Pilpel
    • Department of Membrane Research and BiophysicsThe Weizmann Institute of Science
Article

DOI: 10.1023/A:1006583712886

Cite this article as:
Segré, D., Lancet*, D., Kedem, O. et al. Orig Life Evol Biosph (1998) 28: 501. doi:10.1023/A:1006583712886

Abstract

A Graded Autocatalysis Replication Domain (GARD) model is proposed, which provides a rigorous kinetic analysis of simple chemical sets that manifest mutual catalysis. It is shown that catalytic closure can sustain self-replication up to a critical dilution rate, λc, related to the graded extent of mutual catalysis. We explore the behavior of vesicles containing GARD species whose mutual catalysis is governed by a previously published statistical distribution. In the population thus generated, some GARD vesicles display a significantly higher replication efficiency than most others. GARD thus represents a simple model for primordial chemical selection of mutually catalytic sets.

Copyright information

© Kluwer Academic Publishers 1998