Article

Digestive Diseases and Sciences

, Volume 45, Issue 5, pp 982-986

Prediction of Short-Term Outcome for Patients with Active Ulcerative Colitis

  • Nobuhide OshitaniAffiliated withThird Department of Internal Medicine, Osaka City University Medical SchoolOsaka Municipal Sumiyoshi Shimin Hospital
  • , Takayuki MatsumotoAffiliated withThird Department of Internal Medicine, Osaka City University Medical SchoolOsaka Municipal Sumiyoshi Shimin Hospital
  • , Yoshio JinnoAffiliated withThird Department of Internal Medicine, Osaka City University Medical SchoolOsaka Municipal Sumiyoshi Shimin Hospital
  • , Yoshinori SawaAffiliated withThird Department of Internal Medicine, Osaka City University Medical SchoolOsaka Municipal Sumiyoshi Shimin Hospital
  • , Junichi HaraAffiliated withThird Department of Internal Medicine, Osaka City University Medical SchoolOsaka Municipal Sumiyoshi Shimin Hospital
  • , Shiro NakamuraAffiliated withThird Department of Internal Medicine, Osaka City University Medical SchoolOsaka Municipal Sumiyoshi Shimin Hospital
  • , Tetsuo ArakawaAffiliated withThird Department of Internal Medicine, Osaka City University Medical SchoolOsaka Municipal Sumiyoshi Shimin Hospital
  • , Atsuo KitanoAffiliated withThird Department of Internal Medicine, Osaka City University Medical SchoolOsaka Municipal Sumiyoshi Shimin Hospital
  • , Tetsuo KurokiAffiliated withThird Department of Internal Medicine, Osaka City University Medical SchoolOsaka Municipal Sumiyoshi Shimin Hospital

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Abstract

We report results of a retrospective chart review to evaluate factors predicting short-term outcome of patients with ulcerative colitis treated by corticosteroids. Between January 1992 and December 1997, we treated 71 patients with ulcerative colitis (44 with severe and 27 with moderately severe disease). Forty-nine patients were treated by conventional prednisolone therapy and 22 patients by steroid pulse therapy. There were no differences in clinical or endoscopic improvement between the two treatments. Clinical examination showed that 41 patients entered remission, 17 patients improved, and 13 patients did not respond. Endoscopically, 26 patients entered remission, 30 patients improved, and 15 patients did not respond. Extent of disease, type of disease (first attack, relapsing, or chronic active type), and endoscopic findings were factors useful in predicting short-term outcome of medical treatment.

ulcerative colitis prognosis prediction corticosteroid outcome