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Competence Pheromones in Bacteria

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This article deals with general concepts concerning bacterial pheromones, including sex pheromones. The data on the structure and mode of action of competence pheromones in streptococci and bacilli are discussed, raising the question of the selective value of the process of genetic transformation for bacterial life activities and evolution.

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References

  1. Wirth, R., Muscholl, A., and Wanner, G., The Role of Pheromones in Bacterial Interactions, Trends Microbiol., 1996, vol. 4, no. 3, pp. 96–103.

    Google Scholar 

  2. Fuqua, W.C., Winans, S., and Greenberg, E., Quorum Sensing in Bacteria: The LuxR–LuxI Family of Cell Density–Responsive Transcriptional Regulators, J. Bacteriol., 1994, vol. 176, no. 2, pp. 269–275.

    Google Scholar 

  3. Parkinson, J.S., Kofoid, E.C., Communication Modules in Bacterial Signalling Proteins, Annu. Rev. Genet., 1992, vol. 26. pp. 71–112.

    Google Scholar 

  4. Stock, J.B., Ninfa, A.J., and Stock, A.N., Protein Phosphorylation and Regulation of Adaptive Responses in Bacteria, Microbiol. Rev., 1989, vol. 53, no. 4, pp. 450–490.

    Google Scholar 

  5. Kaiser, D., Losick, R., How and Why Bacteria Talk to Each Other, Cell, 1993, vol. 73, no. 2, pp. 873–885.

    Google Scholar 

  6. Salmond, G., Bycroft, B., Stewart, G., and Williams, P., The Bacterial “Enigma”: Cracking the Code of Cell–Cell Communication, Mol. Microbiol., 1995, vol. 16, no. 4, pp. 615–624.

    Google Scholar 

  7. Kleerebezem, M., Quadri, L., Kuipers, O.P., and de Vos, W., Quorum Sensing by Peptide Pheromones and Two-Component Signal-Transduction Systems in Gram-Positive Bacteria, Mol. Microbiol., 1997, vol. 24, no. 5, pp. 895–904.

    Google Scholar 

  8. Dubnau, D., Genetic Competence in Bacillus subtilis, Microbiol. Rev., 1991, vol. 55, no. 3, pp. 395–424.

    Google Scholar 

  9. Grossman, D.A., Genetic Networks Controlling the Initiation of Sporulation and the Development of Genetic Competence in Bacillus subtilis, Annu. Rev. Genet., 1995, vol. 29, pp. 477–508.

    Google Scholar 

  10. Prozorov, A.A., Cell Differentiation Related to Genetic Transformation in Bacteria and Its Regulation, Mikrobiologiya, 1997, vol. 66, no. 1, pp. 5–13.

    Google Scholar 

  11. Prozorov, A.A., DNA Uptake by the Bacterial Cell: The Natural Process and the Laboratory Methods, Genetika, 1998, vol. 34, no. 5, pp. 581–592.

    Google Scholar 

  12. Pakula, R., Piechovska, M., Bankowska, E., and Walczak, W., A Characteristic of DNA Mediated Transformation of Two Streptococcal Strains, Acta Microbiol. Polonica, 1962, vol. 11, no. 3, pp. 205–221.

    Google Scholar 

  13. Pakula, R., Cybulska, J., and Walczak, W., The Effect of Environmental Factors on Transformability of a Streptococcus, Acta Microbiol. Polonica, 1963, vol. 12, no. 4, pp. 245–258.

    Google Scholar 

  14. Pakula, R. and Walczak, W., On the Nature of Competence of Transformable Streptococci, J. Gen. Microbiol., 1963, vol. 31, no. 1, pp. 125–133.

    Google Scholar 

  15. Pakula, R., Production of Competence-Provoking Factor and Development of Competence of a Transformable Streptococcus in Serum-Free Media, Can. J. Microbiol., 1965, vol. 11, no. 5, pp. 811–822.

    Google Scholar 

  16. Leonard, G., Corley, D., and Cole, R., Transformation of Streptococci in Chemically Defined Media, Biochem. Biophys. Res. Com., 1967, vol. 26, no. 2, pp. 181–186.

    Google Scholar 

  17. Dobrzanski, W. and Osowiecku, H., Isolation and Some Properties of the Competence Factor from Group H Streptococcus Strain Challis, J. Gen. Microbiol., 1967, vol. 48, no. 2, pp. 299–304.

    Google Scholar 

  18. Horne, D. and Perry, D., Effect of Competence Induction on Macromolecular Synthesis in Group H Streptococcus, J. Bacteriol., 1974, vol. 118, no. 3, pp. 830–836.

    Google Scholar 

  19. Tomasz, A. and Hotchkiss, R., Regulation of the Transformability of Pneumococcal Cultures by Macromolecular Cell Products, Proc. Natl. Acad. Sci. USA, 1964, vol. 51, no. 3, pp. 480–486.

    Google Scholar 

  20. Tomasz, A., Control of the Competent State in Pneumococcus by a Hormone-Like Cell Product: An Example for a New Type of Regulatory Mechanism in Bacteria, Nature, 1965, vol. 208, no. 5006, pp. 155–159.

    Google Scholar 

  21. Cellular Metabolism in Genetic Transformation of Pneumoccocci: Requirement for Protein Synthesis during Induction of Competence, J. Bacteriol., 1970, vol. 101, no. 3, pp. 860–871.

  22. Tomasz, A. and Mosser, J., On the Nature of the Pneumococcal Activator Substance, Proc. Natl. Acad. Sci. USA, 1966, vol. 55, no. 1, pp. 58–66.

    Google Scholar 

  23. Morrison, D. and Baker, M., Competence for Genetic Transformation in Pneumococcus Depends on the Synthesis of a Small Set of Proteins, Nature, 1979, vol. 282, no. 5735, pp. 215–217.

    Google Scholar 

  24. Raina, J. and Ravin, A., Switches in Macromolecular Synthesis during Induction of Competence for Transformation of Streptococcus sanguis, Proc. Natl. Acad. Sci. USA, 1980, vol. 77, no. 10, pp. 6062–6066.

    Google Scholar 

  25. Morrison, D.A., Competence-Specific Protein Synthesis in Streptococcus pneumoniae, Transformation-1980, Polsinelli, M. and Mazza, G., Eds., Oxford: Cotswold, 1980, pp. 39–54.

    Google Scholar 

  26. Vijayakumar, M.N. and Morrison, D.A., Localization of Competence-Induced Proteins in Streptococcus pneumoniae, J. Bacteriol., 1986, vol. 165, no. 2, pp. 689–695.

    Google Scholar 

  27. Havarstein, L.S. and Morrison, D.A., Quorum-Sensing and Peptide Pheromones in Streptococcal Competence for Genetic Transformation, Dunny, C.M. and Winans, S.C., Eds., Washington: Am. Soc. Microbiol., 1999, pp. 9–26.

    Google Scholar 

  28. Havarstein, L.S., Coomaraswamy, G., and Morrison, D.A., An Unmodified Heptadecapeptide Pheromone Induces Competence for Genetic Transformation in Streptococcus pneumoniae, Proc. Natl. Acad. Sci. USA, 1995, vol. 92, no. 24, pp. 11140–11144.

    Google Scholar 

  29. Chen, J. and Morrison, D.A., Modulation of Competence for Genetic Transformation in Streptococcus pneumoniae, J. Gen. Microbiol., 1987, vol. 133, no. 5, pp. 1959–1967.

    Google Scholar 

  30. Lee, M. and Morrison, D.A., Identification of a New Regulator in Streptococcus pneumoniae Linking Quorum Sensing to Competence for Genetic Transformation, J. Bacteriol., 1999, vol. 181, no. 16, pp. 5004–5016.

    Google Scholar 

  31. Havarstein, L.S., Gaustad, P., Nes, I., and Morrison, D.A., Identification of the Streptococcal Competence Pheromone Receptor, Mol. Microbiol., 1996, vol. 21, no. 4, pp. 863–869.

    Google Scholar 

  32. Pestova, E.V., Havarstein, L.S., and Morrison, D.A., Regulation of Competence for Genetic Transformation in Streptococcus pneumoniae by an Auto-Induced Peptide Pheromones and a Two-Component Regulatory System, Mol. Microbiol., 1996, vol. 21, no. 4, pp. 853–862.

    Google Scholar 

  33. Campbell, E., Choi, S., and Masure, H.R., A Competence Regulon in Streptococcus pneumoniae Revealed by Genomic Analysis, Mol. Microbiol., 1998, vol. 27, no. 5, pp. 929–939.

    Google Scholar 

  34. Alloing, G., Granadel, C., Morrison, D.A., and Claverys, J.P., Competence Pheromone, Oligopeptide Permease, and Induction of Competence in Stretococcus pneumoniae, Mol. Microbiol., 1996, vol. 21, no. 3, pp. 471–478.

    Google Scholar 

  35. Alloing, G., Martin, B., Granadel, G., and Claveris, J.P., Development of Competence in Streptococcus pneumoniae: Pheromone Autoinduction and Control of Quorum-Sensing by the Oligopeptide Permease, Mol. Microbiol., 1998, vol. 9, no. 1, pp. 75–83.

    Google Scholar 

  36. Ween, O., Gaustad, P., and Havarstein, L.S., Identification of DNA Binding Sites for ComE, a Key Regulator of Natural Competence in Streptococcus pneumoniae, Mol. Microbiol., 1999, vol. 33, no. 4, pp. 817–827.

    Google Scholar 

  37. Pearce, B.J., Naughton, A., and Masure, H., Peptide Permeases Modulate Transformation in Streptococcus pneumoniae, Mol. Microbiol., 1994, vol. 21, no. 6, pp. 881–892.

    Google Scholar 

  38. Pozzi, G., Masala, L., Jannelli, F., Manganelli, R., Havarstein, L.S., Piccoli, L., Simon, D., and Morrison, D.A., Competence for Genetic Transformation in Encapsulated Strains of Streptococcus pneumoniae: Two Allelic Variants of the Peptide Pheromone, J. Bacteriol., 1996, vol. 178, no. 20, pp. 6087–6090.

    Google Scholar 

  39. Havarstein, L.S., Hakenbeck, R., and Gaustad, P., Natural Competence in the Genus Streptococcus: Evidence That Streptococci Can Change Pherotype by Interspecies Recombinational Exchange, J. Bacteriol., 1997, vol. 179, no. 21, pp. 6589–6594.

    Google Scholar 

  40. Charpac, M. and Dedonder, R., Production d'un “facteur competence” soluble par Bacillus subtilis Marburg 168, Compt. Rend. Acad. Sci., 1965, vol. 260, no. 21, pp. 5638–5641.

    Google Scholar 

  41. Pariiskaya, A.A. and Pukhova, E.S., On the Competence Factor of Bacillus subtilis, Mikrobiologiya, 1967, vol. 36, no. 3, pp. 456–463.

    Google Scholar 

  42. Akrigg, A., Ayad, S., and Barker, G., The Nature of a Competence-Inducing Factor in Bacillus subtilis, Biochem. Biophys. Res. Com., 1967, vol. 28, no. 6, pp. 1062–1067.

    Google Scholar 

  43. Arkigg, A. and Ayad, S., The Competence-Inducing Factor of Bacillus subtilis, Biochem. J., 1969, vol. 112, no. 1, pp. 13–16.

    Google Scholar 

  44. Ayad, S. and Scimmin, E., The Existence of Two Forms of the Competence Factor in Bacillus subtilis, Biochem. Soc. Trans., 1973, vol. 1, no. 3, pp. 705–707.

    Google Scholar 

  45. Ayad, S. and Shimmin, E., The Lytic Properties of the Two Forms of the Competence-Inducing Factor in Bacillus subtilis, Biochem. Soc. Trans., 1973, vol. 1, no. 4, pp. 864–866.

    Google Scholar 

  46. Joenje, H., Graber, M., and Venema, G., Stimulation of the Development of Competence by Culture Fluids in Bacillus subtilis Transformation, Biochim. Biophys. Acta, 1972, vol. 262, no. 2, pp. 189–199.

    Google Scholar 

  47. Finn, Ch. and Landman, O., Competence Related Proteins in the Supernatant of Competence Cells of Bacillus subtilis, Mol. Gen. Genet., 1985, vol. 198, no. 2, pp. 329–335.

    Google Scholar 

  48. Goldsmith, M., Havas, S., Ma, R.-J., and Kallenbach, N., Intercellular Effect on Development of Competence in Bacillus subtilis, J. Bacteriol., 1970, vol. 102, no. 3, pp. 774–783.

    Google Scholar 

  49. Magnuson, R., Solomon, J., and Grossman, A.D., Biochemical and Genetic Characterization of a Competence Pheromone from Bacillus subtilis, Cell, 1994, vol. 77, no. 2, pp. 207–216.

    Google Scholar 

  50. Solomon, J., Magnuson, R., Srivastava, A., and Grossman, A.D., Convergent Sensing Pathways Mediate Response to Two Extracellular Competence Factors in Bacillus subtilis, Gene Devel., 1995, vol. 9, no. 5, pp. 547–558.

    Google Scholar 

  51. Solomon, J. and Grossman, A.D., Who's Competent and When: Regulation of Natural Genetic Competence in Bacteria, Trends Genet., 1996, vol. 12, no. 1, pp. 150–155.

    Google Scholar 

  52. Albano, M., Hahn, J., and Dubnau, D., Expression of Competence Genes in Bacillus subtilis, J. Bacteriol., vol. 169, no. 11, pp. 3110–3117.

  53. Prozorov, A.A., The Bacterial Genome: Nucleoid, Chromosome, and Nucleotide Map, Mikrobiologiya, 1998, vol. 67, no. 4, pp. 437–451.

    Google Scholar 

  54. Chan Kam Van, Kuzin, Yu. Yu., Kozlovskii, Yu.E., and Prozorov, A.A., A Study of the Capacity for Genetic Transformation in Soil Isolates Close to Bacillus subtilis 168, Genetika, 1985, vol. 21, no. 12, pp. 1953–1959.

    Google Scholar 

  55. Prozorov, A.A., Horizontal Gene Transfer in Bacteria: Laboratory Modeling, Natural Populations, and Data from Genome Analysis, Mikrobiologiya, 1999, vol. 68, no. 5, pp. 632–646.

    Google Scholar 

  56. Lacks, S.A., DNA Uptake by Transformable Bacteria, Transport of Molecules across Microbial Membranes, Broome-Smith, J. et al., Eds., Cambridge Univ. Press, 1999, pp. 139–188.

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Prozorov, A.A. Competence Pheromones in Bacteria. Microbiology 70, 1–9 (2001). https://doi.org/10.1023/A:1004851316966

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