Neuroprotective Properties of Nootropic Dipeptide GVS-111 in in Vitro Oxygen-Glucose Deprivation, Glutamate Toxicity and Oxidative Stress
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- Andreeva, N.A., Stel'mashuk, E.V., Isaev, N.K. et al. Bulletin of Experimental Biology and Medicine (2000) 130: 969. doi:10.1023/A:1002828707337
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Argon anoxia and glucose deprivation were used for modeling of ischemic damage in the cultures of cerebellar granule cells. Protective effect of peptide piracetam analogue GVS-111 was demonstrated. GVS-111 prevented neurodegeneration induced by glutamate and oxidative stress. In contrast to GVS-111, piracetam did not attenuate neurocytotoxic effect of glutamate.