Article

Inflammation

, Volume 27, Issue 3, pp 129-135

Forsythia fructus Inhibits the Mast-Cell-Mediated Allergic Inflammatory Reactions

  • Mi-Sun KimAffiliated withDepartment of Oriental Pharmacy, College of Pharmacy, Wonkwang UniversityDepartment of Pharmacology, College of Oriental Medicine, Kyung Hee University
  • , Ho-Jeong NaAffiliated withDepartment of Oriental Pharmacy, College of Pharmacy, Wonkwang UniversityDepartment of Pharmacology, College of Oriental Medicine, Kyung Hee University
  • , Seung-Woo HanAffiliated withDepartment of Oriental Pharmacy, College of Pharmacy, Wonkwang University
  • , Jong-Sik JinAffiliated withDepartment of Oriental Pharmacy, College of Pharmacy, Wonkwang University
  • , Un-Yong SongAffiliated withCollege of Oriental Medicine, Wonkwang University
  • , Eon-Jeong LeeAffiliated withCollege of Oriental Medicine, Wonkwang University
  • , Bong-Keun SongAffiliated withCollege of Oriental Medicine, Wonkwang University
  • , Seung-Heon HongAffiliated withDepartment of Oriental Pharmacy, College of Pharmacy, Wonkwang University
  • , Hyung-Min KimAffiliated withDepartment of Pharmacology, College of Oriental Medicine, Kyung Hee University

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Abstract

Mast cells are key as effector cells in the early phase allergic inflammation and in diverse immunological and pathological processes. Forsythia fructus (F. fructus) has used as a traditional medicine for inflammatory diseases. In the present study, we determined the effect of F. fructus extracts on compound 48/80-induced paw oedema and vascular permeability in vivo. In addition, we investigated in vitro whether F. fructus has inhibitory effects on compound 48/80-induced histamine releases from rat peritoneal mast cells (RPMC), and on phorbol 12-myristate 13-acetate (PMA) plus A23187-induced tumor necrosis factor-α (TNF-α) releases from human mast cells (HMC-1). In mice orally administrered F. fructus (100 μg/g) for 1 h, compound-48/80-induced oedema and vascular permeability were significantly reduced rather than those receiving intravenous injection of ketotifen, mast cell stabilizer. F. fructus dose-dependently inhibited the histamine release induced by compound 48/80 from RPMCs. Moreover, F. fructus had no cytotoxic effects on cell viability and had inhibitory effects on TNF-α secretion from HMC-1. These results suggest that F. fructus is a potential herb medicine for treatment of inflammatory diseases through downmodulating mast cell activation.

Forsythia fructus mast cells oedema histamine tumor necrosis factor-α