Inflammation

, Volume 27, Issue 3, pp 129–135

Forsythia fructus Inhibits the Mast-Cell-Mediated Allergic Inflammatory Reactions

Authors

  • Mi-Sun Kim
    • Department of Oriental Pharmacy, College of PharmacyWonkwang University
    • Department of Pharmacology, College of Oriental MedicineKyung Hee University
  • Ho-Jeong Na
    • Department of Oriental Pharmacy, College of PharmacyWonkwang University
    • Department of Pharmacology, College of Oriental MedicineKyung Hee University
  • Seung-Woo Han
    • Department of Oriental Pharmacy, College of PharmacyWonkwang University
  • Jong-Sik Jin
    • Department of Oriental Pharmacy, College of PharmacyWonkwang University
  • Un-Yong Song
    • College of Oriental MedicineWonkwang University
  • Eon-Jeong Lee
    • College of Oriental MedicineWonkwang University
  • Bong-Keun Song
    • College of Oriental MedicineWonkwang University
  • Seung-Heon Hong
    • Department of Oriental Pharmacy, College of PharmacyWonkwang University
  • Hyung-Min Kim
    • Department of Pharmacology, College of Oriental MedicineKyung Hee University
Article

DOI: 10.1023/A:1023865727780

Cite this article as:
Kim, M., Na, H., Han, S. et al. Inflammation (2003) 27: 129. doi:10.1023/A:1023865727780

Abstract

Mast cells are key as effector cells in the early phase allergic inflammation and in diverse immunological and pathological processes. Forsythia fructus (F. fructus) has used as a traditional medicine for inflammatory diseases. In the present study, we determined the effect of F. fructus extracts on compound 48/80-induced paw oedema and vascular permeability in vivo. In addition, we investigated in vitro whether F. fructus has inhibitory effects on compound 48/80-induced histamine releases from rat peritoneal mast cells (RPMC), and on phorbol 12-myristate 13-acetate (PMA) plus A23187-induced tumor necrosis factor-α (TNF-α) releases from human mast cells (HMC-1). In mice orally administrered F. fructus (100 μg/g) for 1 h, compound-48/80-induced oedema and vascular permeability were significantly reduced rather than those receiving intravenous injection of ketotifen, mast cell stabilizer. F. fructus dose-dependently inhibited the histamine release induced by compound 48/80 from RPMCs. Moreover, F. fructus had no cytotoxic effects on cell viability and had inhibitory effects on TNF-α secretion from HMC-1. These results suggest that F. fructus is a potential herb medicine for treatment of inflammatory diseases through downmodulating mast cell activation.

Forsythia fructusmast cellsoedemahistaminetumor necrosis factor-α
Download to read the full article text

Copyright information

© Plenum Publishing Corporation 2003