Journal of Structural and Functional Genomics

, Volume 3, Issue 1, pp 195–199

Phylogenetic analysis of the mammalian Hoxc8 non-coding region

  • Chang-Bae Kim
  • Cooduvalli S. Shashikant
  • Kenta Sumiyama
  • Wayne C.H. Wang
  • Chris T. Amemiya
  • Frank H. Ruddle
Article

DOI: 10.1023/A:1022635623260

Cite this article as:
Kim, CB., Shashikant, C.S., Sumiyama, K. et al. J Struct Func Genom (2003) 3: 195. doi:10.1023/A:1022635623260

Abstract

The non-coding intergenic regions of Hox genes are remarkably conserved among mammals. To determine the usefulness of this sequence for phylogenetic comparisons, we sequenced an 800-bp fragment of the Hoxc9–Hoxc8 intergenic region from several species belonging to different mammalian clades. Results obtained from the phylogenetic analysis are congruent with currently accepted mammalian phylogeny. Additionally, we found a TC mini satellite repeat polymorphism unique to felines. This polymorphism may serve as a useful marker to differentiate between mammalian species or as a genetic marker in feline matings. This study demonstrates usefulness of a comparative approach employing non-coding regions of Hox gene complexes.

comparative genomics Hox genes mammalian phylogeny Hox genes mammalian phylogeny 

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Chang-Bae Kim
    • 1
  • Cooduvalli S. Shashikant
    • 2
  • Kenta Sumiyama
    • 1
  • Wayne C.H. Wang
    • 2
  • Chris T. Amemiya
    • 3
  • Frank H. Ruddle
    • 1
  1. 1.Department of Molecular, Cellular, and Developmental BiologyYale UniversityNew HavenUSA
  2. 2.Genetic Resources CenterKorea Research Institute of Bioscience and BiotechnologyTaejonKorea
  3. 3.Department of Dairy and Animal Science, College of Agricultural SciencesThe Pennsylvania State UniversityUniversity ParkUSA
  4. 4.Department of Molecular GeneticsVirginia Mason Research CenterSeattleUSA