Antonie van Leeuwenhoek

, Volume 81, Issue 1, pp 3–13

Defences against oxidative stress during starvation in bacteria

  • Diane McDougald
  • Lan Gong
  • Sujatha Srinivasan
  • Erika Hild
  • Lyndal Thompson
  • Kathy Takayama
  • Scott A. Rice
  • S. Kjelleberg
Article

DOI: 10.1023/A:1020540503200

Cite this article as:
McDougald, D., Gong, L., Srinivasan, S. et al. Antonie Van Leeuwenhoek (2002) 81: 3. doi:10.1023/A:1020540503200

Abstract

It now seems clear that starvation adaptation is important for cells to initiate long-term survival under conditions of not only nutrient depletion but to develop resistance to other stresses, most notably oxidative stress. Clearly, oxidative stress is a condition likely to be perceived by many bacteria, for example, in the form of reactive oxygen species derived from metabolic processes or from near-UV exposure. We have found evidence for a large degree of overlap in the cell's use of global regulators to deal with both starvation and oxidative stress. Both SpoT and AI-2 signalling pathways are important regulators of starvation and stress adaptation as well as the alternative sigma factor, RpoE. We also present evidence that suggests that AI-2 signalling can mediate starvation adaptation at the molecular level by increasing the stability of the mRNAs so that cells are prepared for rapid response to nutrient addition. Moreover, such extracellular signals mediate intraspecies communication to enable enhanced survival and stress resistance of neighbouring bacterial cells. It is likely that bacteria rely on a suite of effects between cells and on transcription, translation and post-translational processes, mediated by global regulators and signalling molecules, to meet their needs for growth and survival.

oxidative stressquorum sensingsigma factorssignalling systemsSpoTstarvationvibrio

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Diane McDougald
    • 1
  • Lan Gong
    • 1
  • Sujatha Srinivasan
    • 1
  • Erika Hild
    • 1
  • Lyndal Thompson
    • 1
  • Kathy Takayama
    • 1
  • Scott A. Rice
    • 1
  • S. Kjelleberg
    • 1
  1. 1.School of Biotechnology and Biomolecular Sciences, Microbiology and Immunology and The Centre for Marine Biofouling and Bio-InnovationUniversity of New South WalesSydneyAustralia