Pharmaceutical Research

, Volume 4, Issue 6, pp 445–449

The Influence of Drugs on Nasal Ciliary Movement

  • Walter A. J. J. Hermens
  • Frans W. H. M. Merkus

DOI: 10.1023/A:1016463118748

Cite this article as:
Hermens, W.A.J.J. & Merkus, F.W.H.M. Pharm Res (1987) 4: 445. doi:10.1023/A:1016463118748


Drugs in nasal preparations, for local use as well as for systemic use, should not interfere with the self-cleaning capacity of the nose, effectuated by the ciliary epithelium. Many drugs and additives, however, have a negative effect on nasal ciliary function. Examples of ciliotoxic agents are lipophilic and mercuric preservatives, local anesthetics, antihistamines, propranolol, and absorption enhancers such as the bile salts. Cholinergic drugs and β-adrenergic drugs exert a ciliostimulatory effect. It is the purpose of this review to summarize the present knowledge of ciliotoxicity of drugs and additives and to give recommendations for the use of ciliofriendly drugs in nasal preparations.

ciliary movementciliotoxicitynasal drug delivery

Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • Walter A. J. J. Hermens
    • 1
  • Frans W. H. M. Merkus
  1. 1.Center for Bio-Pharmaceutical SciencesLeiden UniversityRA LeidenThe Netherlands