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Fungal Metabolism of 4-Methylprimaquine

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Abstract

4-Methylprimaquine (4-MPQ), an 8-aminoquinoline antimalarial drug, was subjected to microbial metabolism studies in an effort to isolate, identify, and predict the probable mammalian metabolite(s). Preliminary screening with a number of strains of Aspergillus indicated that several species were capable of metabolizing 4-MPQ to one major metabolite based on thin-layer chromatographic analysis. Preparative scale conversion of 4-MPQ using whole-cell suspensions of Aspergillus ochraceus afforded one major metabolite (4-MPQ-I). Based on spectroscopic and chemical evidence, the structure of the metabolite is proposed as 6-methoxy-8-(3-carboxyl-l-methylpropylamino)-lepidine.

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Authors and Affiliations

  1. Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677

    Alice M. Clark, James D. McChesney & Charles D. Hufford

Authors
  1. Alice M. Clark
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  2. James D. McChesney
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  3. Charles D. Hufford
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Clark, A.M., McChesney, J.D. & Hufford, C.D. Fungal Metabolism of 4-Methylprimaquine. Pharm Res 3, 170–172 (1986). https://doi.org/10.1023/A:1016318125534

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  • DOI: https://doi.org/10.1023/A:1016318125534

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