Article

Russian Chemical Bulletin

, Volume 51, Issue 5, pp 854-859

Application of the Thorpe—Ziegler reaction for the synthesis of functionalized thiophenes, thienopyrimidines, and thienotriazines

  • S. A. RyndinaAffiliated withState Scientific Center of the Russian Federation “Organic Intermediate Products and Dyes Institute” (NIOPIK)
  • , A. V. KadushkinAffiliated withState Scientific Center of the Russian Federation “Organic Intermediate Products and Dyes Institute” (NIOPIK)
  • , N. P. Solov"evaAffiliated withCenter of Drug Chemistry, All-Russian Research Chemical Pharmaceutical Institute
  • , V. G. GranikAffiliated withState Scientific Center of the Russian Federation “Organic Intermediate Products and Dyes Institute” (NIOPIK)

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Abstract

Approaches to the synthesis of 3-aminothiophene-2,4-dicarboxylic acid derivatives and to their conversions into thieno[3,4-d]pyrimidines, thieno[3,4-d]-1,2,3-triazines, and thieno[3,2-d]pyrimidines are developed.

enamines the Thorpe—Ziegler cyclization thiophenes pyrimidines 1,2,3-triazines