Bulletin of Experimental Biology and Medicine

, Volume 133, Issue 3, pp 290–292

Effects of Epithalon on Activities Gastrointestinal Enzymes in Young and Old Rats

Authors

    • St. Petersburg Institute of Bioregulation and GerontologyNorthwestern Division of the Russian Academy of Medical Sciences
    • I. P. Pavlov Institute of PhysiologyRussian Academy of Sciences
  • V. V. Malinin
    • St. Petersburg Institute of Bioregulation and GerontologyNorthwestern Division of the Russian Academy of Medical Sciences
    • I. P. Pavlov Institute of PhysiologyRussian Academy of Sciences
  • N. M. Timofeeva
    • St. Petersburg Institute of Bioregulation and GerontologyNorthwestern Division of the Russian Academy of Medical Sciences
    • I. P. Pavlov Institute of PhysiologyRussian Academy of Sciences
  • V. V. Egorova
    • St. Petersburg Institute of Bioregulation and GerontologyNorthwestern Division of the Russian Academy of Medical Sciences
    • I. P. Pavlov Institute of PhysiologyRussian Academy of Sciences
  • A. A. Nikitina
    • St. Petersburg Institute of Bioregulation and GerontologyNorthwestern Division of the Russian Academy of Medical Sciences
    • I. P. Pavlov Institute of PhysiologyRussian Academy of Sciences
Article

DOI: 10.1023/A:1015807305791

Cite this article as:
Khavinson, V.K., Malinin, V.V., Timofeeva, N.M. et al. Bulletin of Experimental Biology and Medicine (2002) 133: 290. doi:10.1023/A:1015807305791

Abstract

Peroral administration of Epithalon (Ala-Glu-Asp-Gly) to male and female Wistar rats aging 3 and 11 months changed activity of enzymes hydrolyzing carbohydrates, proteins, and phosphoric acid esters in various portions of the gastrointestinal tract. The most pronounced activation of enzymes was observed in 11-month-old animals. This effect diminished the differences in enzyme activities between young and old rats (compared to untreated animals). Our results indicate that Epithalon modulates activity of gastrointestinal enzymes during aging.

Epithalon peptides digestive enzymes gastrointestinal tract aging

Copyright information

© Plenum Publishing Corporation 2002