References
Barrett JC. A multistep model for neoplastic development: a role of genetic and epigenetic changes. In: Barrett JC, ed. Mechanisms of Environmental Carcinoegnesis, vol vn2 Multi-steps models of Carcinogenesis Boca Raton FL: CRC Press, 1987; 117–26.
Cairns J. The origin of human cancers. Nature, 1981; 289: 353–7.
Wintersberger U. Chemical carcinogenesis – the price for DNA repair? Naturwissenschaften 1982; 69: 107–13.
Haluska FG, Tsujimoto Y, Croce CM. Oncogene activation by chromosome translocation in human malignancy. Annu Rev Genet 1987; 21: 321–45.
Varmus HE. The molecular genetics of cellular oncogenes. Annu Rev Genet 1984; 18: 553–612.
Bishop JM. The molecular genetics of cancer. Science, 1987; 235: 305–11.
Hansen MF, Cavanee WK. Tumor suppressors: Recessive mutations that lead to cancer. Cell, 1988; 53: 172–3.
Ponder B. Gene losses in human tumors. Nature, 1988; 335: 400–2.
Mitelman F, Heim S. Chromosome abnormalities in cancer. Cancer Detection and Prevention 1990; 14: 527–37.
Sandberg AA. Chromosome abnormalities in human cancer and leukemia: Mutat. Res., 1991; 247: 231–40.
Barrett JC. Mechanism of multistep carcinogenesis and carcinogen risk assessment. Environm. Health Perpect. 1993; 100: 9–20.
Ramel C. Mutation spectrum in carcinogenicity, In: A. Kappas ed. Mechanosms of Environmental Mutagenesis-Carcinogenesis, New York: Plenum Press, 1990: 1–3.
Wügler FE. Recombination and gene conversion. Mutat Res 1992; 284: 3–14
Meyn MS. High spontaneous intrachromosomal recombination rates in ataxia telangiectasia. Science 1993; 260: 1327–30.
Malkin D, Li FP, Strong LC, Fraumeni JF Jr., Nelson CE, Kim DH, Kassel J, Gryka MA, Bischoff FZ, Tainsky MA, Friend SH. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas and other neoplasms. Science, 1990; 250: 1233–8.
Weinert T, Lydall D. Cell cycle checkpoints, genetic instability and cancer, Seminar in Cancer Biol. 1993; 4: 129–40.
Hartwell LH. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell 1992a; 71: 543–6.
Murnane JP. Role of induced genetic instability in the mutagenic effects of chemical and radiation. Mutation Res. 1996; 367: 11–23.
Watt PM, Hickson ID. Genome instability: Failure to unwind causes cancer. Current Biology 1996; 6: 265–7.
Yuspa SH, Poirier MC. Chemical carcinogenesis from animal models to molecular models in one decade. Adv Cancer Res 1988; 50: 25–70.
Grisham JW, Kaufmann WK, Kaufman DG. The cell cycle and the chemical carcinogenesis. Surv Synth Path Res 1983; 1: 49–66.
Kaufmann WK, Kaufman DG. Cell cycle control, DNA repair and initiation of carcinogenesis. FASEB J 1993; 7: 1188–91.
Hartwell LH. Role of yeast in cancer research. Cancer 1992b; 69(10): 2615–21.
Schiestl RH, Igarashi S, Hastings PJ. Analysis of the mechanism for reversion of a disrupted gene. Genetics 1988; 119: 237–47.
Schiestl RH. Nonmutagenic carcinogens induce intrachromosomal recombination in yeast. Nature 1989; 337: 285–8.
Schiestl RH, Gietz RD, Mehta RD, Hastings PJ. Carcinogens induce intrachromosomal recombination in yeast. Carcinogenesis 1989; 10: 1445–55.
Schiestl RH. Nonmutagenic carcinogens induce intrachromosomal recombination in dividing yeast cells. Env Health Perspect 1993; In press.
Carls N, Schiestl RH. Evaluation of the yeast DEL assay with ten compounds selected by the International Program on Chemical Safety for the evaluation of short-term tests for carcinogens. Mutat Res 1994; 320: 293–303.
Melnick RL, Huff J, Barrett JC, Maronpot RR, Lucier G, Portier JC. Cell proliferation and Chemical Carcinogenesis: a symposium overview. Mol Carcinog 1993; 7: 135–8.
Pringle JR, Hartwell LH. The Sacchromyces cerevisiae cell cycle, In: Stratern JN, Jones EW, Broach JR (eds), The molecular biology of the Yeast Saccharomyces, Cold Spring Harbor Laboratory. New York: Cold Spring Harbor NY, 1981: 97–142.
Tonaletti S, Pfeifer GP. UV damage and repair mechanisms in mammalian cells. BioEssays 1996; 18: 221–8.
Friedberg EC, Walker GC, Siede W. DNA repair and mutagenesis. ASM Press, Washington, DC: ASM Press, 1995.
Galli A, Schiestl RH. On the mechanism of UV and g-rays-induced intrachromosomal recombination in yeast cells synchronized in different stages of the cell cycle. Mol Gen Genet 1995a; 248: 301–10.
Galli A, Schiestl RH. Salmonella test positive and negative carcinogens show different effect on intrachromosomal recombination in G2 cell cycle arrested yeast cells. Carcinogenesis 1995; 16: 659–63.
IARC (1987) International Agency for Research on Cancer. Monographs on the evaluation of carcinogenic risks to humans, Supplement 7. Overall evaluation of carcinogenicity: an updating of selected IARC monographs from volume 1–42. Lyon, France.
Arcos JC, Argus MF. Chemical Induction of Cancer, vol II (A & B), New York: Academic Press, 1974.
McCann J, Choi E, Yamasaki E, Ames BN. Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals. Proc Natl Acad Sci USA, 1975; 72; 5135–9.
De Flora S, Zanacchi P, Camoirano A, Bemecelli C, Badolati GS. Genotoxic activity of 135 compounds in the Ames reversion test and in a bacterial DNA repair test. Mutat Res, 1984; 133: 161–98.
Ashby J, Tennant RW. Definitive relationship among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP, Mutat Res 1992; 275: 229–306.
Kaufmann WK, Paules RS. DNA damage and cell cycle checkpoints. FASEB J 1996; 10: 238–47.
Reddy MV, Randerath K. A comparison of DNA adductd formation in white blood cells and internal organs of mice exposed to benzo(a)pyrene, dibenzo(c,g)carbazole, safrole and cigarette smoke condensate. Mutat Res 1990; 241: 37–48.
Gupta KP, van Golen KL, Putman KL, Randerath K. Formation and persistence of safrole-DNA adducts over a 10,000-fold dose range in mouse liver. Carcinogenesis 1993; 14: 1517–21.
Chan VS, Caldwell J. Comparative induction of unscheduled DNA synthesis in cultured rat hepatocytes by allylbenzenes and their 1 0-hydroxy mrtabolites. Food Chem Toxicol 1992; 30: 8–836.
Foureman P, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compound tested for the National Toxicology Program. Environm. Mol. Mutag., 1994; 23: 51–63.
Zimmermann FK, Mohr A. Formaldehyde, glyoxal, urethane, methyl carbamate, 2,3-butanedione, 2,3-hexanedione, ethyl acrylate, dibromoacetonitrile and 2-hydroxypropionitrile induce loss in Saccharomyces cerevisiae. Mutation Res 1992; 270: 151–66.
Batiste-Alentorn M, Xamena N, Creus A, Marcos R. Genotoxicity studies with the unstable zeste-white (UZ) system of Drosophila melanogasters: Results with 10 carcinogenic compounds. Environm Mol Mutag 1991; 18: 120–5.
Frautz R, Forster R, Hechenberger CM, Hertner T, von der Hude W, Kaufman G, Madle H, Madle S, Miltenburger HG, Muller L et al. Report of comparative study of DNA damage and repair assays in primary rat hepatocytes with five coded chemicals. Mutat Res 1991; 260: 281–94.
Jackson MA, Stack HF, Wates MD. The genetic toxicology of putative nongenotoxic carcinagens. Mutat Res 1993; 296: 241–77.
Eastmond DA. Induction of micronuclei and aneuploidy by the quinone-forming agents benzene and o-phenylphenol. Toxicol Lett 1993; 67: 105–18.
Ward JB Jr, Ammenheuse MM, Ramanujam VM, Morris DL, Whorton EB Jr., Legator MS. The mutagenic effects of low level sub-acute inhalation exposure to benzene in CD-1 mice. Mutat Res 1992; 268: 49–57.
Low LK, Reddy MV, Blackburn GR, Mackerer CR. Final report: Benzene mechanistic research project. Environmental and health laboratory, Mobil Oil Corporation, Princeton NJ.
Klein HL. Genetic control of intrachromosomal recombination. BioEssays 1995; 17: 147–59.
Haber JE. Exploring the pathways of homologous recombination. Curr Opin Cell Biol 1992; 4: 401–12.
Belmaaza A, Chartrand P. One-sided invasion events in homologous recombination at double strand breaks. Mutation Res 1994; 314: 199–208.
Kadyk LC, Hartwell LH. Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae. Genetics 1992; 132: 382–402.
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Galli, A., Schiestl, R.H. Yeast strains to detect genomic deletions induced by carcinogens in cell-cycle arrested cells. Biotherapy 11, 129–133 (1998). https://doi.org/10.1023/A:1007978011313
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DOI: https://doi.org/10.1023/A:1007978011313