Skip to main content
SpringerLink
Log in

New trends in biological monitoring: application of biomarkers to genetic ecotoxicology

  • Published:
Biotherapy

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Wogan GN, Gorelick NJ. Chemical and biochemical dosimetry to exposure to genotoxic chemicals. Environ Health Perspec 1985; 62: 5–18.

    Google Scholar 

  2. Kohn H.W. The significance of DNA-damaging assays in toxicity and carcinogenicity assessment. Ann NY Acad Sci 1983; 407: 106–18.

    Google Scholar 

  3. Committee on Biological Markers of the National Research Council:Biological markers in environmental health research. Environ Health Perspec 1987; 74: 3–9.

    Google Scholar 

  4. Shugart LR. Biological monitoring: testing for genotoxicity. In: McCarthy J. and Shugart L. (eds). Biological Markers of Environmental Contaminants, Boca Raton, FL: Lewis Publishers Inc, 1990: 205–16.

    Google Scholar 

  5. Shugart LR, McCarthy JF, Halbrook RS. Biological markers of environmental and ecological contamination: an overview. Risk Analysis 1992; 12: 353–60.

    Google Scholar 

  6. Martineau D, Lagace A, Beland P, Higgins R, Armstrong D, Shugart LR. Pathology of stranded beluga whales (Delphinapterus leucas) from the St. Lawrence Estuary, Quebec, Canada. J Comp Path 1988; 98: 287–311.

    Google Scholar 

  7. Shugart LR. Detection and quantitation of benzo[a]pyrene-DNA adducts in brain and liver tissues of beluga whales (Delphinapterus leucas) from the St. Lawrence and Mackenzie estuaries. In: Proceeding of the international forum for the future of the beluga. Quebec: Presses de l'Universite du Quebec, 1990; 219–23.

    Google Scholar 

  8. Shugart LR, Holland J, Rahn R. Dosimetry of PAH carcinogenesis: covalent binding of BaP to mouse epidermal DNA. Carcinogenesis 1983; 4: 195–8.

    Google Scholar 

  9. Shugart LR, Bickham J, Jackim G, McMahon G, Ridley W, Stein J, Steiner S. DNA alterations. In: Huggett R, Kimerle R, Mehrle P, Bergman H, (eds). Biomarkers: Biochemical, Physiological, and Histological Markers of Anthropogenic Stress, Boca Raton, FL: Lewis Publishers Inc, 1992: 127–53.

    Google Scholar 

  10. Shugart LR. Quantitation of chemically induced damage to DNA of aquatic organisms by alkaline unwinding assay. Aquatic Tox 1998; 13: 43–52.

    Google Scholar 

  11. Meyers-Schone L, Shugart LR, Beauchamp JJ, Walton BT. Comparison of two freshwater turtle species as monitors of radionuclide and chemical contamination: DNA damage and residue analysis.Environ Tox Chem 1993; 12: 1487–96.

    Google Scholar 

  12. Lamb T, Bickham JW, Gibbons JW, Smolen MJ, McDowell S. Genetic damage in a population of slider turtles (Trachemys scripta) inhabiting a radioactive reservoir. Arch Environ Contam Tox 1991; 20: 138–42.

    Google Scholar 

  13. Shugart LR. DNA damage as an indicator of pollutant-induced genotoxicity. In: Landis WG, van der Schalie WH. (eds). 13th Symposium on Aquatic Toxicology and Risk Assessment: Sublethal Indicators of Toxic Stress, Philadelphia, PA: ASTM, 1990: 348–55.

    Google Scholar 

  14. Theodorakis CW, D'surney SJ, Bickham JW, Lyne TB, Bradley BP, Hawkins WE, Farkas WL, McCarthy JF, Shugart LR. Sequential expression of biomarkers in bluegill sunfish exposed to contaminated sediment. Ecotoxicology 1992; 1: 45–73.

    Google Scholar 

  15. Theodorakis CW, D'surney SJ, Shugart LR. Detection of genotoxic insult as DNA strand breaks in fish blood cells by agarose gel electrophoresis. Environ. Tox. Chem., 1994; 13: 1023–31.

    Google Scholar 

  16. Cicerone RJ. Changes in stratospheric ozone. Science 1987; 237: 35–42.

    Google Scholar 

  17. Caldwell MM. Plant life and ultraviolet radiation: some perspectives in the history of the earth's UV climate.BioScience 1970; 29: 520–5.

    Google Scholar 

  18. McEvers JA, Hileman MS, Edwards NT. Air pollution effects field research facility: 3. UV-B exposure and monitoring system. ORNL/TM-11607, 1993.

  19. D'surney SJ, Tschaplinski TJ, Edwards NT, and Shugart LR. Biological responses of two soybean cultivars exposed to enhanced UVB radiation. Environ Exp Botany 1993; 33: 347–56.

    Google Scholar 

  20. Anderson S, Sadinski W, Shugart L, Brussard P, Depledge M, Ford T, Hose J, Stegeman J, Suk W, Wirgin I, Wogan G. Genetic and molecular ecotoxicology: a research framework. Environ. Health Perspec., 1994; 102: 3–8. bibitemThaler DS. The evolution of genetic intelligence. Science 1994; 264: 224–5.

    Google Scholar 

  21. Guengerich FP. Cytochrome P450 enzymes. Am. Sci., 1993; 81: 440–7.

    Google Scholar 

  22. Shugart LR. Molecular and biochemical responses to toxic agents. In: Newman MC, Jagoe CH, (eds.), Quantitative Ecotoxicology: A Hierarchical Approach Boca Raton, FL: Lewis Publishers Inc., 1995: 133–61.

    Google Scholar 

  23. Brusick, D. Principles of Genetic Toxicology, New York, NY: Plenum Press, 1980.

    Google Scholar 

  24. Thilly WG, Call KM. Genetic toxicology, In: Klaassen DD, Amdur MO, Doull J, (eds.) Third Edition of Casarett and Doull's Toxicology, New York, NY: Macmillan Publishing Co., 1986: 174–9.

    Google Scholar 

  25. Clive D. Genetic toxicology: from theory to practice. Clin. Res. Drug Development, 1987; 1: 11–41.

    Google Scholar 

  26. Wurgler FE, Kramers PGN. Environmental effects of genotoxins (ecogenotoxicology). Mutagenesis, 1992; 7: 321–7.

    Google Scholar 

  27. Bickham JW, Smolen MJ. Somatic and heritable effects of environmental genotoxins and the emergence of evolutionary toxicology. Environ. Health Perspec., 1994; 102: 25–8.

    Google Scholar 

  28. Depledge MH. The rational basis for the use of biomarkers as ecotoxicological tools, In: Fossi MC, Leonzio C. eds. Nonde-structive Biomarkers in Vertebrates, Boca Raton, FL: Lewis Publishers Inc., 1992: 271–95.

    Google Scholar 

  29. Theodorakis CW, Shugart LR. Genetic Ecotoxicology I: DNA integrity and reproduction in mosquitofish exposed in situ to radionuclides. Ecotoxicology, 1996, in press

  30. Shugart LR, Theodorakis C. Environmental genotoxicity: probing the underlying mechanisms, Environ. Health Perspec., 1994; 102: 13–7.

    Google Scholar 

  31. Shugart LR, Theodorakis C. Genetic ecotoxicology: The genotypic diversity approach, Comp Biochem Physiol, 1996; 113: 273–276.

    Google Scholar 

  32. Shugart LR. State of the art-ecological biomarkers. In: Travis CC. (ed). Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants, New York: Plenum Press, 1993: 237–45.

    Google Scholar 

  33. McCarthy JF, Shugart LR (eds.) Biomarkers of Environmental Contamination, Boca Raton, FL: Lewis Publishers Inc., 1990.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. LR Shugart and Associates, Inc., P.O. Box 5564, Oakridge, TN, 37831-5564, USA

    Lee Shugart & Christopher Theodorakis

Authors
  1. Lee Shugart
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christopher Theodorakis
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shugart, L., Theodorakis, C. New trends in biological monitoring: application of biomarkers to genetic ecotoxicology. Biotherapy 11, 119–127 (1998). https://doi.org/10.1023/A:1007911027243

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1007911027243

Keywords

Search

Navigation