Veterinary Research Communications

, Volume 28, Issue 8, pp 669–680

Serum Levels of 25-Hydroxycholecalciferol and 1,25-Dihydroxycholecalciferol in Dogs with Hypercalcaemia

  • B. Gerber
  • B. Hauser
  • C.E. Reusch
Article

DOI: 10.1023/B:VERC.0000045954.71403.74

Cite this article as:
Gerber, B., Hauser, B. & Reusch, C. Vet Res Commun (2004) 28: 669. doi:10.1023/B:VERC.0000045954.71403.74

Abstract

1,25-Dihydroxycholecalciferol (1,25-(OH)2-D3) and 25-hydroxycholecalciferol (25-OH-D3) were measured among dogs with hypercalcaemia (total serum calcium >3.01 mmol/L) due to various causes. All values were compared to those of healthy control dogs. Serum 1,25-(OH)]2-D3 was measured by a radioimmunoassay test and serum 25-OH-D3 was measured by a protein binding assay. 1,25-(OH)2-D3 ranged from 26 to 332 pmol/L (median 110.0) in dogs with lymphoma (n = 12); from 61 to 398 pmol/L (median 248.0) in dogs with primary hyperparathyreoidism (n = 5); from 28 to 310 pmol/L (median 88.5) in dogs with chronic renal failure (n = 10); and from 60 to 239 pmol/L (median 157.5) in control dogs (n = 24).There was no significant difference in 1,25-(OH)2-D3 among dogs with different causes of hypercalcaemia. 25-OH-D3 ranged from 64 to 291 nmol/L (median 101.5) in dogs with lymphoma; from 66 to 298 nmol/L (median 91.0) in dogs with primary hyperparathyreoidism; from 35 to 184 nmol/L (median 67.0) in dogs with chronic renal failure; and from 48 to 350 nmol/L (median 306.5) in control dogs. 25-OH-D3 was significantly lower in dogs with lymphoma, primary hyperparathyroidism and chronic renal failure than in control dogs. 1,25-(OH)2-D3 and 25-OH-D3 are not predictable in dogs with hypercalcaemia.

1,25-dihydroxycholecalciferol dog 25-hydroxycholecalciferol hypercalcaemia vitamin D 

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • B. Gerber
    • 1
  • B. Hauser
    • 2
  • C.E. Reusch
    • 1
  1. 1.Clinic for Small Animal Internal MedicineUniversity of ZurichZurichSwitzerland
  2. 2.Institute of Veterinary PathologyUniversity of ZurichSwitzerland

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