, Volume 35, Issue 3, pp 393-397

Oxidative stress markers and C-reactive protein in end-stage renal failure patients on dialysis

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Abstract

Objective:The inflammatory status is awell-documented factor influencing thedevelopment of oxidative stress in dialysispatients. This study intends to evaluate theinflammatory activity and the plasma levels oftotal antioxidant capacity (TAC) and lipidperoxidation products in patients on peritonealdialysis (PD), by comparison with hemodialysis(HD) patients.Patients and Methods: Plasmaconcentration of TAC, lipid peroxidationproducts and C-reactive protein (CRP) weremeasured in 24 patients on PD, 32 HD patients(pre and post treatment) and 16normal controls (NC).Results: All patients had higher levelsof TAC and lipid peroxidation products than NC(p < 0.001). Patients on PD, had similar levelsto patients before HD but significantly higher(p < 0.001) than those post HD. The CRPconcentration was higher in HD than in PDpatients (p < 0.05). The percentage of patientswith CRP > 10 mg/l was 48% in HD patients and21% in PD patients. No correlation was observedbetween CRP and TAC nor CRP and MDA levels.Conclusions: We conclude thatalthough PD and HD patients show an equalsusceptibility in oxidative stress, CRPlevels are higher in HD patients and this isindicative of a higher degree of inflammatoryactivity in these patients.

An erratum to this article is available at http://dx.doi.org/10.1007/s11255-007-9248-0.