Article

Somatic Cell and Molecular Genetics

, Volume 24, Issue 3, pp 197-202

First online:

Chromosomal Mapping of a Skeletal Muscle Specific LIM-Only Protein FHL3 to the Distal End of the Short Arm of Human Chromosome 1

  • Simon Ming Yuen LeeAffiliated withDepartment of Biochemistry and The Hong Kong Bioinformatics Center, The Chinese University of Hong Kong
  • , Stephen Kwok Wing TsuiAffiliated withDepartment of Biochemistry and The Hong Kong Bioinformatics Center, The Chinese University of Hong Kong
  • , Kwok Keung ChanAffiliated withDepartment of Biochemistry and The Hong Kong Bioinformatics Center, The Chinese University of Hong Kong
  • , Masayo KotakaAffiliated withDepartment of Biochemistry and The Hong Kong Bioinformatics Center, The Chinese University of Hong Kong
  • , Hoi Yeung LiAffiliated withDepartment of Biochemistry and The Hong Kong Bioinformatics Center, The Chinese University of Hong Kong
  • , Stephen Siu Chung ChimAffiliated withDepartment of Biochemistry and The Hong Kong Bioinformatics Center, The Chinese University of Hong Kong
  • , Mary Miu Yee WayeAffiliated withDepartment of Biochemistry and The Hong Kong Bioinformatics Center, The Chinese University of Hong Kong
  • , Kwok Pui FungAffiliated withDepartment of Biochemistry and The Hong Kong Bioinformatics Center, The Chinese University of Hong Kong
  • , Cheuk Yu LeeAffiliated withDepartment of Biochemistry and The Hong Kong Bioinformatics Center, The Chinese University of Hong Kong

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Abstract

Four-and-a-halfLIM domain proteins (FHL) possess four tandem repeats of LIM domain and an extra zinc finger. FHL family LIM proteins are unique when compared with other LIM-only proteins because they possess an odd number of zinc fingers. In this study, the tissue distribution and chromosomal mapping of skeletal muscle LIM protein FHL3 were reported. When the FHL3 cDNA probe was used to hybridize with poly-(A) RNA of various human tissues, a very strong signal was detected in skeletal muscle, and virtually no signal could be detected in heart, brain, placenta, lung, liver, kidney and pancreas. Using radiation hybrid technique, FHL3 gene was mapped to the distal end of the short arm of chromosome 1 (123.26 cR from the top of the Chr1 linkage group) and this region (near 1p34) is related to several human malignancies.