Russian Journal of Organic Chemistry

, Volume 40, Issue 7, pp 976-981

First online:

An Efficient One-Pot Synthesis of Triamides and Amidodiesters

  • A. Shaabani
  • , M. B. Teimouri
  • , H. R. Bijanzadeh

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An efficient one-pot procedure has been proposed for the synthesis of compounds containing three carboxamide groups or one carboxamide and two ester groups. The procedure is based on three-component condensation of alkyl isocyanides with 5-alkylidene- or 5-arylmethylene-substituted Meldrum's acids in the presence of such nucleophiles as phenols and amines.