Neurochemical Research

, Volume 29, Issue 3, pp 629–635

Substantial Linkage Disequilibrium Across the Dihydrolipoyl Succinyltransferase Gene Region Without Alzheimer's Disease Association

  • Abraham M. Brown
  • Derek Gordon
  • Hsinhwa Lee
  • Michael Caudy
  • Vahram Haroutunian
  • John P. Blass
Article

DOI: 10.1023/B:NERE.0000014833.54481.1d

Cite this article as:
Brown, A.M., Gordon, D., Lee, H. et al. Neurochem Res (2004) 29: 629. doi:10.1023/B:NERE.0000014833.54481.1d

Abstract

Association of the candidate gene DLST with late-onset Alzheimer's disease (LOAD) risk has been suggested on the basis of case-control studies. This gene, located on chromosome 24q24.3, encodes a subunit of a mitochondrial component known to be defective in AD, the α-ketoglutarate dehydrogenase complex. Positive reports have correlated different DLST alleles with LOAD, whereas other groups have failed to find any significant association. We therefore reexamined the association of DLST and LOAD in a more ethnically homogeneous series using three additional single nucleotide polymorphisms (SNP) located within or closely flanking either end of the DLST gene. Pairwise analysis of these SNPs indicated there was strong linkage disequilibrium across the DLST locus. Analysis of complex genotypes or haplotypes based upon all five SNP loci failed to identify a LOAD risk allele, suggesting that further studies of DLST in relation to AD are not warranted.

Energy metabolismmitochondriageneAlzheimer's diseasepolymorphism

Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • Abraham M. Brown
    • 1
    • 2
  • Derek Gordon
    • 5
  • Hsinhwa Lee
    • 1
  • Michael Caudy
    • 1
    • 3
  • Vahram Haroutunian
    • 6
  • John P. Blass
    • 1
    • 3
    • 4
  1. 1.Burke Medical Research InstituteWhite Plains
  2. 2.Department of BiochemistryWeill Medical College of Cornell UniversityNew York
  3. 3.Department of Neurology and NeuroscienceWeill Medical College of Cornell UniversityNew York
  4. 4.Department of MedicineWeill Medical College of Cornell UniversityNew York
  5. 5.Laboratory of Statistical GeneticsRockefeller UniversityNew York
  6. 6.Department of Psychiatry, Mount Sinai School of MedicineBronx Veterans Administration Medical CenterBronx