Solution-phase reductive cyclization of 2-quinoxalinol analogs: Systematic study of parallel synthesis
- Cite this article as:
- Wu, XH., Liu, G., Zhang, J. et al. Mol Divers (2004) 8: 165. doi:10.1023/B:MODI.0000025639.89179.60
- 158 Downloads
1,5-Difluoro-2,4-dinitrobenzene starting material was treated via primary and/or secondary substitution with a variety of amino acids or amines and the aromatic m-dinitro groups were then reductively cyclized provide the 2-quinoxalinol analogs. The conditions for 1,5-dialkylamino-2,4-dinitrobenzene reduction have been systematically studied and optimized in solution. Three effective methods are described for the high-throughout generation of 2-quinoxalinol analogs.