Molecular Diversity

, Volume 8, Issue 2, pp 165–174

Solution-phase reductive cyclization of 2-quinoxalinol analogs: Systematic study of parallel synthesis

  • Xiang-Hong Wu
  • Gang Liu
  • Jing Zhang
  • Zhan-Guo Wang
  • Song Xu
  • Suo-De Zhang
  • Liang Zhang
  • Lin Wang
Article

DOI: 10.1023/B:MODI.0000025639.89179.60

Cite this article as:
Wu, XH., Liu, G., Zhang, J. et al. Mol Divers (2004) 8: 165. doi:10.1023/B:MODI.0000025639.89179.60

Abstract

1,5-Difluoro-2,4-dinitrobenzene starting material was treated via primary and/or secondary substitution with a variety of amino acids or amines and the aromatic m-dinitro groups were then reductively cyclized provide the 2-quinoxalinol analogs. The conditions for 1,5-dialkylamino-2,4-dinitrobenzene reduction have been systematically studied and optimized in solution. Three effective methods are described for the high-throughout generation of 2-quinoxalinol analogs.

aromatic nitro reductionm-dinitro benzeneparallel synthesis2-quinoxalinol analogreductive cyclizationsolution-phase

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Xiang-Hong Wu
    • 1
  • Gang Liu
    • 1
  • Jing Zhang
    • 1
  • Zhan-Guo Wang
    • 1
  • Song Xu
    • 1
  • Suo-De Zhang
    • 1
  • Liang Zhang
    • 1
  • Lin Wang
    • 1
  1. 1.Institute of Materia MedicaChinese Academy of Medical Sciences & Peking Union Medical CollegeBeijingP. R. China