, Volume 6, Issue 3-4, pp 193-197

Ugi reaction in aqueous solutions: A simple protocol for libraries production

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Abstract

A reaction between levulinic acid, isocyanides and primary amines has been examined in distilled water and in surfactants solutions. It is demonstrated that the reaction gives good results at the different concentrations including one well above the solubility limit. A simple and eco-friendly protocol for libraries production is described.

This revised version was published online in June 2006 with corrections to the Cover Date.