Molecular and Cellular Biochemistry

, Volume 264, Issue 1, pp 99-102

First online:

Integrative signaling in angiogenesis

  • Michael SimonsAffiliated withAngiogenesis Research Center and Section of Cardiology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center

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Angiogenesis is a complex process requiring integration of multiple signals in order to achieve successful development of the new vasculature. While individual activities of numerous growth factors are well understood, the integration of their signaling at the cellular and tissue level is just beginning to be appreciated. This review focuses on these two process using vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) as examples. (Mol Cell Biochem 264: 99–102, 2004)

growth factors FGF VEGF arteriogenesis