Journal of Mammary Gland Biology and Neoplasia

, Volume 9, Issue 1, pp 39–53

Transcriptional Control of the Cell Cycle in Mammary Gland Development and Tumorigenesis

  • Ricardo D. Coletta
  • Paul Jedlicka
  • Arthur Gutierrez-Hartmann
  • Heide L. Ford
Article

DOI: 10.1023/B:JOMG.0000023587.40966.f6

Cite this article as:
Coletta, R.D., Jedlicka, P., Gutierrez-Hartmann, A. et al. J Mammary Gland Biol Neoplasia (2004) 9: 39. doi:10.1023/B:JOMG.0000023587.40966.f6

Abstract

Over the past several years it has become increasingly evident that normal development and cancer share many properties. Both processes involve alterations in cell proliferation and differentiation, cell death, neovascularization, and cell motility and invasion. Thus, genes involved in normal development are frequently utilized in neoplasia. During development, numerous transcriptional regulatory mechanisms are used to ensure tight control over cellular proliferation. In this review we focus on a number of transcription factor families (homeobox, STAT, and Ets), and on inhibitors of transcription factors (Id), which have been implicated in controlling the cell cycle not only in normal mammary gland development but also in breast tumorigenesis.

transcription factorshomeobox genesSix familySTATEtsIdcell cycle controlproliferationmammary gland developmentbreast cancer

Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • Ricardo D. Coletta
    • 1
    • 2
  • Paul Jedlicka
    • 3
    • 4
    • 5
  • Arthur Gutierrez-Hartmann
    • 3
    • 6
  • Heide L. Ford
    • 1
    • 6
  1. 1.Department of Obstetrics and GynecologyUniversity of Colorado Health Sciences CenterDenver
  2. 2.Discipline of PathologyUniversity of Campinas Dental SchoolPiracicaba, SPBrazil
  3. 3.Department of MedicineUniversity of Colorado Health Sciences CenterDenver
  4. 4.Department of PathologyUniversity of Colorado Health Sciences CenterDenverColorado
  5. 5.Department of PathologyThe Children's HospitalDenverColorado
  6. 6.Department of Biochemistry and Molecular GeneticsUniversity of Colorado Health Sciences CenterDenver