Article

Journal of Mammary Gland Biology and Neoplasia

, Volume 8, Issue 4, pp 383-394

First online:

Integrins in Mammary Gland Development and Differentiation of Mammary Epithelium

  • Ilaria TaddeiAffiliated withUMR 144 CNRS-Institut Curie, Section de Recherche
  • , Marisa M. FaraldoAffiliated withUMR 144 CNRS-Institut Curie, Section de Recherche
  • , Jérôme TeulièreAffiliated withUMR 144 CNRS-Institut Curie, Section de Recherche
  • , Marie-Ange DeugnierAffiliated withUMR 144 CNRS-Institut Curie, Section de Recherche
  • , Jean Paul ThieryAffiliated withUMR 144 CNRS-Institut Curie, Section de Recherche
  • , Marina A. GlukhovaAffiliated withUMR 144 CNRS-Institut Curie, Section de Recherche Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Integrins are major extracellular matrix (ECM) receptors that can also serve for some cell–cell interactions. They have been identified as important regulators of mammary epithelial cell growth and differentiation. Their ability to promote cell anchorage, proliferation, survival, migration, and the induction of active ECM-degrading enzymes suggests that they play an essential role in normal mammary morphogenesis, but, on the other hand, reveals their potential to promote tumor progression.

integrins mammary epithelium differentiation morphogenesis tumor progression