Journal of Fluorescence

, Volume 14, Issue 6, pp 677–679

Metal-Enhanced Fluorescence Solution-Based Sensing Platform

  • Kadir Aslan
  • Joseph R. Lakowicz
  • Henryk Szmacinski
  • Chris D. Geddes
Article

DOI: 10.1023/B:JOFL.0000047217.74943.5c

Cite this article as:
Aslan, K., Lakowicz, J.R., Szmacinski, H. et al. Journal of Fluorescence (2004) 14: 677. doi:10.1023/B:JOFL.0000047217.74943.5c

Abstract

In recent years our laboratories have reported the favorable effects for fluorophores placed in close proximity to surface immobilized silver nanostructures. These include; greater quantum yields, reduced lifetimes (increased photostability) and directional emission. However, while these findings are likely to find multifarious applications for surface assays based on enhanced fluorescence detection, a solution based enhanced sensing platform has yet to be realized. In this short, note, we show how SiO2-coated silver colloids, indeed provide for a solution based enhanced fluorescence sensing platform with a 3–5 fold enhancement typically observed.

Radiative decay engineering metal-enhanced fluorescence solution assays 

Copyright information

© Springer Science+Business Media, Inc. 2004

Authors and Affiliations

  • Kadir Aslan
    • 1
  • Joseph R. Lakowicz
    • 2
  • Henryk Szmacinski
    • 3
  • Chris D. Geddes
    • 1
  1. 1.Institute of Fluorescence, Medical Biotechnology CenterUniversity of Maryland Biotechnology InstituteBaltimoreMaryland
  2. 2.Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, Medical Biotechnology CenterUniversity of Maryland School of MedicineBaltimoreMaryland
  3. 3.Microcosm Inc.ColumbiaMaryland

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