Journal of Clinical Immunology

, Volume 24, Issue 2, pp 170–176

The Autoantibody Repertoire Against Copper- or Macrophage-Modified LDL Differs in Normolipidemics and Hypercholesterolemic Patients

  • Eva C. Fernvik
  • Daniel F. J. Ketelhuth
  • Momtchilo Russo
  • Magnus Gidlund
Article

DOI: 10.1023/B:JOCI.0000019782.67993.0b

Cite this article as:
Fernvik, E.C., Ketelhuth, D.F.J., Russo, M. et al. J Clin Immunol (2004) 24: 170. doi:10.1023/B:JOCI.0000019782.67993.0b

Abstract

We have analyzed the antibody repertoire from normo- and hypercholesterolemic subjects to investigate how it can be related to macrophage-dependent modification of low-density lipoproteins, in comparison to the commonly used copper-oxidized LDL. Preexisting natural antibodies in plasma from normo- and hypercholesterolemic individuals were tested for their reactivity against copper ion oxidized LDL and LDL modified by macrophages. A crosswise comparison between these two antigen preparations demonstrated a different antibody repertoire in normo- and hypercholesterolemic patients. This study suggest that the search for antibodies that can influence the progression or regression of an atherosclerotic process has to take into account the process by which LDL is modified, and the repertoire of antibodies that is generated in the normal population, in comparison to that with, or at risk for, coronary artery diseases.

Antibodies oxLDL atherosclerosis and macrophages 

Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • Eva C. Fernvik
    • 1
  • Daniel F. J. Ketelhuth
    • 1
  • Momtchilo Russo
    • 1
  • Magnus Gidlund
    • 1
  1. 1.Department of ImmunologyInstitute of Biomedical Sciences, University of São PauloSão PauloBrazil

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