Glycoconjugate Journal

, Volume 20, Issue 1, pp 39–47

Glycosphingolipids and cell death

Article

DOI: 10.1023/B:GLYC.0000016741.88476.8b

Cite this article as:
Bektas, M. & Spiegel, S. Glycoconj J (2003) 20: 39. doi:10.1023/B:GLYC.0000016741.88476.8b

Abstract

Sphingolipids have been implicated in various cellular processes including growth, cell-cell or ligand-receptor interactions, and differentiation. In addition to their importance as reservoirs of metabolites with important signaling properties, sphingolipids also help provide structural order to plasma membrane lipids and proteins within the bilayer. Glycosylated sphingolipids, and sphingomyelin in particular, are involved in the formation of lipid rafts. Although it is well accepted that ceramide, the backbone of all sphingolipids, plays a critical role in apoptosis, less is known about the biological functions of glycosphingolipids. This review summarizes current knowledge of the involvement of glycosphingolipids in cell death and in other pathological processes and diseases. Published in 2004.

glycosphingolipids apoptosis GD3 glucosylceramide 

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  1. 1.Department of BiochemistryVirginia Commonwealth University School of MedicineRichmondUSA

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