Glycoconjugate Journal

, Volume 19, Issue 7, pp 615-619

First online:

The involvement of galectin-1 in skeletal muscle determination, differentiation and regeneration

  • Diana J. WattAffiliated withDepartment of Anatomy, Brighton and Sussex Medical School Email author 
  • , Gareth E. JonesAffiliated withRandall Centre for Molecular Mechanisms of Cell Function, King's College London
  • , Kirstin GoldringAffiliated withUK Parkinson's Disease Society Tissue Bank at Imperial College, Division of Neuroscience & Psychological Medicine, Imperial College Faculty of Medicine

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The dogma that a cell is rigidly committed to one tissue type has been heavily challenged over the past few years with numerous reports of transdifferentiation of cells between different lineages. Cells capable of entering lineages other than that of their tissue of origin have been identified in several diverse tissues. Recently we have focussed on a non-committed myogenic cell within the dermis that is capable, under certain conditions, of expressing muscle specific markers and even fusing to the terminally differentiated stage of muscle cell development. We have identified galectin-1 as being a potent factor implicated in this process. In this review we discuss our findings and consider the involvement of galectin-1 in muscle determination, differentiation and regeneration. Published in 2004.

galectin-1 muscle development dermal fibroblasts