Glycoconjugate Journal

, Volume 19, Issue 7, pp 583–591

Seeing strangers or announcing “danger”: Galectin-3 in two models of innate immunity


DOI: 10.1023/

Cite this article as:
Sato, S. & Nieminen, J. Glycoconj J (2002) 19: 583. doi:10.1023/


Recent investigations on the molecular mechanisms by which our immune system recognizes infections and initiates defense against those infections have led to the proposition of two models explaining the way our innate immunity system functions; the self-nonself model and the Danger model. In this review, the roles of galectin-3 in innate immunity against infections—host-pathogen interactions—will be discussed. We will shed light on the potential contribution of a β-galactoside binding mammalian lectin, galectin-3 as a molecule implicated in innate immunity from the angle of both the self-nonself model and the Danger model. Published in 2004.

galectin-3innate immunityinfectious diseasesthe danger modelthe self-nonself model

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  1. 1.Glycobiology Laboratory, Research Centre for Infectious DiseasesLaval University, Medical Centre, Centre Hospitalier Universitaire de QuébecSte-FoyCanada