Glycoconjugate Journal

, Volume 19, Issue 7, pp 451–458

The speciation of conger eel galectins by rapid adaptive evolution

Authors

    • Department of Biomolecular Science, Graduate School of Life SciencesTohoku University
  • Tsuyoshi Shirai
    • Department of Computational BiologyBiomolecular Engineering Research Institute
  • Clara Shionyu-Mitsuyama
    • Department of Computational BiologyBiomolecular Engineering Research Institute
  • Takashi Yamane
    • Department of Biotechnology and Biomaterial Chemistry, Graduate School of EngineeringNagoya University
  • Hisao Kamiya
    • School of Fisheries SciencesKitasato University
  • Koji Muramoto
    • Department of Biomolecular Science, Graduate School of Life SciencesTohoku University
Article

DOI: 10.1023/B:GLYC.0000014074.38755.1d

Cite this article as:
Ogawa, T., Shirai, T., Shionyu-Mitsuyama, C. et al. Glycoconj J (2002) 19: 451. doi:10.1023/B:GLYC.0000014074.38755.1d

Abstract

Many cases of accelerated evolution driven by positive Darwinian selection are identified in the genes of venomous and reproductive proteins. This evolutional phenomenon might have important consequences in their gene-products' functions, such as multiple specific toxins for quick immobilization of the prey and the establishment of barriers to fertilization that might lead to speciation, and in the molecular evolution of novel genes. Recently, we analyzed the molecular evolution of two galectins isolated from the skin mucus of conger eel (Conger myriaster), named congerins I and II, by cDNA cloning and X-ray structural analysis, and we found that they have evolved in the rapid adaptive manner to emergence of a new structure including strand-swapping and a unique new ligand-binding site. In this review article we summarize and discuss the molecular evolution, especially the rapid adaptive evolution, and the structure-function relationships of conger eel galectins. Published in 2004.

adaptive evolutionconger eeldomain swappinggalectinX-ray crystal structure

Copyright information

© Kluwer Academic Publishers 2002