, Volume 120, Issue 1, pp 79–86

Molecular Polymorphism in Drosophila Melanogaster and D. Simulans: what have we Learned from Recent Studies?


  • Sylvain Mousset
    • Laboratoire d’EcologieUniversité Paris VI, CNRS UMR 7625
    • Laboratoire Biologie Intégrative des PopulationsÉcole Pratique des Hautes Études
    • Dept. Biology IILudwig-Maximilians-University
  • Nicolas Derome
    • Laboratoire Populations, Génétique et EvolutionCNRS UPR 9034
    • Laboratoire Biologie Intégrative des PopulationsÉcole Pratique des Hautes Études

DOI: 10.1023/B:GENE.0000017632.08718.df

Cite this article as:
Mousset, S. & Derome, N. Genetica (2004) 120: 79. doi:10.1023/B:GENE.0000017632.08718.df


We present a review of recent studies of molecular polymorphism in Drosophila melanogaster and D. simulans. The availability of African and non-African samples for these species makes it possible to compare microsatellite and DNA sequence polymorphism between these species, both inside and outside their native regions. There are four main results: (i) variability is larger in African populations; (ii) variation is usually higher on the autosomes, except for African D. melanogaster; (iii) DNA sequence variation is higher on D. simulans than on D. melanogaster autosomes; (iv) the ratio of replacement to silent polymorphisms is higher for D. melanogaster autosomal loci. We summarize the main hypotheses put forward to explain these results.

AfricaDNA sequence polymorphismDrosophila melanogasterDrosophila simulansmicrosatellite variationpopulation genetics

Copyright information

© Kluwer Academic Publishers 2004