European Journal of Epidemiology

, Volume 19, Issue 3, pp 225–230

Increased risk for cardiovascular mortality in psoriasis inpatients but not in outpatients

Authors

    • Dermatology UnitKarolinska Hospital
  • Olof Akre
    • Clinical Epidemiology Unit, Department of MedicineKarolinska Institute
  • Fredrik Granath
    • Clinical Epidemiology Unit, Department of MedicineKarolinska Institute
  • Li Yin
    • Clinical Epidemiology Unit, Department of MedicineKarolinska Institute
  • Bernt Lindelöf
    • Clinical Epidemiology Unit, Department of MedicineKarolinska Institute
  • Anders Ekbom
    • Clinical Epidemiology Unit, Department of MedicineKarolinska Institute
  • Mona Ståhle-Bäckdahl
    • Clinical Epidemiology Unit, Department of MedicineKarolinska Institute
Article

DOI: 10.1023/B:EJEP.0000020447.59150.f9

Cite this article as:
Mallbris, L., Akre, O., Granath, F. et al. Eur J Epidemiol (2004) 19: 225. doi:10.1023/B:EJEP.0000020447.59150.f9

Abstract

We have conducted a historical cohort study to assess cardiovascular mortality among psoriasis patients. Using the Swedish Inpatient Registry, we selected 8991 patients hospitalized for psoriasis at dermatological wards. To represent an outpatient cohort, 19,757 members of the Swedish Psoriasis Association were selected. Mortality from cardiovascular diseases was compared with the general population. We found no increased cardiovascular mortality among outpatients with psoriasis (standardized mortality ratio, SMR 0.94; 95% confidence interval, CI: 0.89–0.99). The overall risk among inpatients admitted at least once was increased by 50%(SMR 1.52; 95% CI: 1.44–1.60). The excess risk increased with increasing number of hospital admissions (p for trend <0.001). Cardiovascular mortality was higher among those admitted at younger ages (p for trend <0.001; SMR 2.62, 95% CI: 1.91–3.49, for patients aged 20 to 39 years at first admission). Young age at first admission appeared to further increase the risk among those who were repeatedly admitted. We conclude that a diagnosis of psoriasis per se does not appear to increase the risk for cardiovascular mortality. Severe psoriasis, however, here measured as repeated admissions, and early age at first admission, is associated with increased risk for cardiovascular death.

AtherosclerosisCardiovascular deathEpidemiologyInflammationPsoriasis

Copyright information

© Kluwer Academic Publishers 2004