Case–control study of environmental risk factors for Parkinson's disease in Belgium
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The aetiology of Parkinson's disease (PD) is unknown and said to be multifactorial. We report on a retrospective epidemiological case control study, performed in Flanders during a 3-year period, investigating known and potential environmental risk factors for PD by means of questionnaires. We investigated 423 prevalent patients and 205 spouse-controls. We found familial occurrence in 15% of the patients, a mean age of onset of 58 years, and a clear male preponderance (male/female ratio 1.53). Our results suggest more nulliparity among female PD patients (95% CI: 1.08–5.76). We found a discrete clustering of patients in areas with intensive metallurgic activity. Patients were more frequently employed in metallurgy than controls (95% CI: 1.04–9.20). Furthermore, patients were clearly more exposed to zinc (95% CI: 1.51–90.90) and toluene (95% CI: 1.03–58.82). Male patients report more prostatectomy-surgery (95% CI: 1.54–17.24).
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About this Article
- Case–control study of environmental risk factors for Parkinson's disease in Belgium
European Journal of Epidemiology
Volume 18, Issue 12 , pp 1133-1142
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- Organophosphates and comorbidity
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- Author Affiliations
- 1. Laboratory of Neurobiology, Born Bunge Foundation, University of Antwerp, Wilrijk, Belgium
- 2. Department of Neurology, University Hospital of Antwerp, Edegem, Belgium
- 3. Department of Occupational Medicine, Neurotoxicology Section, University Hospital St. Raphaël, Belgium
- 4. Department of Neurology, AZ St. Lucas Ziekenhuis, Belgium
- 5. Department of Neurology, Ghent University Hospital, Gent, Belgium
- 6. Laboratory of Neuropathology, Born Bunge Foundation, University of Antwerp, Wilrijk, Belgium