Digestive Diseases and Sciences

, Volume 49, Issue 7, pp 1128–1135

Double-Peaked High-Pressure Zone at the Esophagogastric Junction in Controls and in Patients with a Hiatal Hernia: A Study Using High-Resolution Manometry

  • A. J. Bredenoord
  • B. L. A. M. Weusten
  • S. Carmagnola
  • A. J. P. M. Smout
Article

DOI: 10.1023/B:DDAS.0000037799.29678.94

Cite this article as:
Bredenoord, A.J., Weusten, B.L.A.M., Carmagnola, S. et al. Dig Dis Sci (2004) 49: 1128. doi:10.1023/B:DDAS.0000037799.29678.94

Abstract

The lower esophageal high-pressure zone (HPZ) consists of the intrinsic lower esophageal sphincter (LES) and the diaphragmatic sphincter. In patients with a hiatal hernia these constituents are separated. We performed high-resolution manometry of the esophagogastric HPZ in six controls, six patients with a small hernia, and six patients with a large hernia. Prevalence of a double-peak pressure profile of the HPZ was noted. Pressures and distances between the peaks were assessed. Prevalence of the double-peak profile was similar between patients with a small hernia and controls, but patients with a large hernia showed a higher prevalence with inspiration (P<0.05) than the others. The distance between the two peaks was larger in patients with a large hernia (P<0.05). In conclusion, high-resolution manometry makes it possible to distinguish the diaphragmatic pressure component from the LES. Two pressure peaks can be found both in hernia patients and in healthy volunteers.

hiatal hernia high-resolution manometry esophagogastric junction esophageal manometry esophageal motility 

Copyright information

© Springer Science+Business Media, Inc. 2004

Authors and Affiliations

  • A. J. Bredenoord
    • 1
  • B. L. A. M. Weusten
    • 1
  • S. Carmagnola
    • 2
  • A. J. P. M. Smout
    • 2
  1. 1.Department of GastroenterologySint Antonius HospitalNieuwegeinThe Netherlands
  2. 2.Gastrointestinal Research Unit, Department of GastroenterologyUniversity Medical CenterUtrechtThe Netherlands

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