Digestive Diseases and Sciences

, Volume 49, Issue 6, pp 982–989

The Bile Acid Nuclear Receptor FXR and the Bile Acid Binding Protein IBABP Are Differently Expressed in Colon Cancer

  • Andrea De Gottardi
  • Fethi Touri
  • Christoph A. Maurer
  • Anne Perez
  • Oliver Maurhofer
  • Giovanni Ventre
  • Craig L. Bentzen
  • Eric J. Bentzen
  • Jean-Francois Dufour
Article

DOI: 10.1023/B:DDAS.0000034558.78747.98

Cite this article as:
De Gottardi, A., Touri, F., Maurer, C.A. et al. Dig Dis Sci (2004) 49: 982. doi:10.1023/B:DDAS.0000034558.78747.98

Abstract

Bile acids have been implicated in the development of colorectal cancers. We investigated the ex-pressionof the transcription factor regulated by bile acids, farnesoid X receptor (FXR), as well asother components of this pathway in human colorectal tumors and cell lines. The most significantchanges were a decrease in FXR mRNA levels in adenomas (5-fold average) and carcinomas (10fold average) and an increase in peroxisome proliferator activated receptor-γ (2-fold average). FXRwas not expressed in undifferentiated colon adenocarcinoma SW480 cells and metastasis derivedSW620 cells. In Caco-2 and HT-29 cells, the level of FXR expression increased with the degree ofdifferentiation. Intestinal bile acid binding protein was activated by chenodeoxycholic acid and thesynthetic FXR agonist GW4064 in Caco-2 and HT-29 but not in SW cells unless FXR was trans-fected.The down-regulation of the nuclear receptor FXR in colon cancer might be of clinical andpharmacological importance.

farnesoid X receptorbile acid nuclear receptorcolon cancerintestinal bile acid binding proteincolorectal cancer

Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • Andrea De Gottardi
    • 1
  • Fethi Touri
    • 2
  • Christoph A. Maurer
    • 3
  • Anne Perez
    • 2
  • Oliver Maurhofer
    • 2
  • Giovanni Ventre
    • 2
  • Craig L. Bentzen
    • 2
  • Eric J. Bentzen
    • 2
  • Jean-Francois Dufour
    • 4
  1. 1.Division of Gastroenterology and HepatologyUniversity HospitalGeneva
  2. 2.ILEX Oncology ResearchVersoix
  3. 3.Department of SurgeryKantonsspitalLiestal
  4. 4.Department for Clinical PharmacologyUniversity of BernBernSwitzerland