Gastric and Duodenal Mucosal Protein Fractional Synthesis and Growth Factor Expression in Patients with H. pylori-Associated Gastritis Before and After Eradication of the Organism
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- Winter, T.A., Kidd, M., Kaye, P. et al. Dig Dis Sci (2004) 49: 925. doi:10.1023/B:DDAS.0000034550.08623.9b
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Our purpose was to study the effect of Helicobacter pylori (HP) on mucosal protein fractionalsynthesis (MPFS) and growth factor expression. 14 C-leucine incorporation, and TGF-α, β-FGF, andEGF-receptor levels were assessed in gastric and duodenal mucosa in 20 patients with HP-associatedgastritis and repeated after treatment of the gastritis, with or without eradication of the organism.At entry, MPFS in the fundus, antrum, and duodenum was 43.1, 38.2, and 28.3%/day, respectively.Following HP eradication, fundal and antral rates fell to 28.1 and 21.4%/day ( P < 0:05), whereasthe duodenum was unchanged. MPFS in the patient subset not eradicated remained similar to entryvalues (35.9, 31.6, and 25.4%/day). Expression of TGF-α, β-FGF, and EGFreceptors was unchanged.Eradication of HP results in reduction of gastric, but not duodenal, MPFS and has no effect on thegrowth factors measured. Increased MPFS associated with HP gastritis may relate to the potentialfor neoplastic transformation.