Metabolites of the Sea Isolate of Bacteria Streptomyces sp. 6167
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- Sobolevskaya, M.P., Fotso, S., Havash, U. et al. Chemistry of Natural Compounds (2004) 40: 282. doi:10.1023/B:CONC.0000039143.59854.6e
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Sea isolate of Streptomyces sp. 6167 was found to produce four macrolide antibiotics feigrisolides A, B, and D, and dinactin. The chemical structures of the compounds were determined using 1D and 2D NMR spectrometry and electrospray mass spectrometry (ESMS). It was shown that the feigrisolides are cytotoxic to Ehrlich carcinoma tumor cells and to egg-cells of the sea urchin Strongylocentrotus intermedius and antimicrobial to the bacteria Bacillus cereus and Escherichia coli.