, Volume 21, Issue 3, pp 185-189

ICAM-1 supports adhesion of human small-cell lung carcinoma to endothelial cells

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Adhesion of tumor cells to endothelium via cell-adhesion molecules constitutes a crucial step in metastasis, which is largely responsible for the poor prognosis of small-cell lung carcinoma (SCLC). Patients with SCLC were reported to have elevated levels of intercellular adhesion molecule-1 (ICAM-1). The present study therefore focuses on endothelial ICAM-1 in tumor-cell adhesion. We found that the adherence of SCLC cells (cell lines H24, H69, H82) to cultured vascular endothelium in stasis and flow depends on the expression of ICAM-1. After blocking endothelial ICAM-1 with monoclonal antibodies, adhesion was significantly reduced. These results pinpoint ICAM-1 for the first time as a molecule crucially involved in SCLC cell-endothelial adhesion.

Abbreviations: ECGS – endothelial cell growth supplement; FCS – fetal calf serum; HUVECs – human umbilical vein endothelial cells; ICAM-1 – intercellular adhesion molecule-1; IL-1β– Interleukin-1β; SCLC – small-cell lung carcinoma

This revised version was published online in July 2006 with corrections to the Cover Date.