Cancer Causes & Control

, Volume 15, Issue 8, pp 771–780

Tobacco and Alcohol Consumption and the Risk of Non-Hodgkin Lymphoma

  • Eleanor V Willett
  • Alexandra G. Smith
  • Gareth J. Dovey
  • Gareth J. Morgan
  • Jan Parker
  • Eve Roman
Article

DOI: 10.1023/B:CACO.0000043427.77739.60

Cite this article as:
Willett, E.V., Smith, A.G., Dovey, G.J. et al. Cancer Causes Control (2004) 15: 771. doi:10.1023/B:CACO.0000043427.77739.60

Abstract

Objective: The aim was to test whether non-Hodgkin lymphoma (NHL) is associated with smoking or alcohol.

Methods: A case-control study recruited NHL cases aged 18-64 in parts of England between 1998 and 2001. One control was matched to each case on sex, date of birth and area of residence. Self-reported histories of tobacco and alcohol consumption were collected during face-to-face interviews.

Results: Among 700 cases and 915 controls, no association of smoking with the risk of NHL was observed [odds ratio (OR)= 1.04, 95% confidence interval (CI): 0.85-1.28]. Risks were not raised with age started smoking, number of years smoked, and number of years stopped smoking. Compared with persons who drank alcohol once or twice a week, neither abstainers (OR = 1.03, 95% CI: 0.64-1.67), nor consumers of alcohol one to five times a year (OR = 1.35, 95% CI: 0.95-1.93), one to two times a month (OR = 1.20, 95% CI: 0.87-1.65), three to four times a week (OR = 0.82, 95% CI: 0.62-1.10), or most days (OR = 0.94, 95% CI: 0.70-1.25) increased their risk of developing NHL. Average daily volume or high occasional alcohol consumption were not associated with NHL.

Conclusions: NHL was not associated with smoking or alcohol, but collaborative studies could further investigate the risks of rarer WHO subtypes following these exposures.

tobaccoalcoholnon-Hodgkin lymphomaepidemiologycase-control study

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Eleanor V Willett
    • 1
  • Alexandra G. Smith
    • 1
  • Gareth J. Dovey
    • 1
  • Gareth J. Morgan
    • 2
  • Jan Parker
    • 1
  • Eve Roman
    • 1
  1. 1.Department of Health Sciences, Leukaemia Research Fund Epidemiology and Genetics Unit, Seebohm Rowntree BuildingUniversity of YorkYorkUK
  2. 2.Institute of Cancer ResearchThe Royal MarsdenSurreyUK