Occupation and Bladder Cancer Risk in a Population-based Case-control Study in New Hampshire
10.1023/B:CACO.0000043426.28741.a2 Cite this article as: Colt, J.S., Baris, D., Stewart, P. et al. Cancer Causes Control (2004) 15: 759. doi:10.1023/B:CACO.0000043426.28741.a2 Abstract Objective: To identify occupations with excess bladder cancer risk in New Hampshire, where bladder cancer mortality rates have been elevated for decades. Methods: Lifetime occupational histories were obtained from interviews with 424 cases and 645 controls in a population-based case-control study.Unconditional logistic regression models were used to estimate odds ratios (Ors) and 95% confidence intervals (CI) for each occupation, adjusted for age and smoking. Analyses by duration of employment were carried out and interactions with smoking were examined. Results: Male tractor-trailer truck drivers had an elevated risk for bladder cancer (OR = 2.4, CI = 1.4-4.1), with a significant positive trend in risk with increasing duration of employment ( P trend= 0.0003). Male metal/plastic processing machine operators also had a significant excess (OR = 4.9, CI = 1.6-15.1), attributable mainly to molding/casting machine operators (OR = 16.6, CI = 2.1-131). Elevated risk was also observed for male fabricators, assemblers, and hand workers (OR = 1.8, CI = 1.0-3.4). Women in certain sales occupations (sales clerks, counter clerks, and cashiers) had a significant excess risk (OR = 2.2, CI = 1.3-3.9) and a significant trend with duration of employment ( P trend= 0.016), as did female health service workers (OR = 4.1, CI = 1.6-10.7; P trend= 0.014). There was a positive interaction between smoking and employment as a health service worker ( p= 0.036). Conclusions: These findings are generally consistent with previous studies. Elevated risks for male molding/casting machine operators, female salesworkers, and female health service workers, especially those with a history of smoking, require further investigation. bladder cancer occupation case-control study epidemiology References
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