Article

Cancer Causes & Control

, Volume 15, Issue 8, pp 759-769

Occupation and Bladder Cancer Risk in a Population-based Case-control Study in New Hampshire

  • Joanne S. ColtAffiliated withDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of HealthDepartment of Health and Human Services, Occupational And Environmental Epidemiology Branch
  • , Dalsu BarisAffiliated withDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
  • , Patricia StewartAffiliated withDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
  • , Alan R. SchnedAffiliated withDepartment of Community and Family Medicine, Dartmouth Medical School, Dartmouth College
  • , John A. HeaneyAffiliated withDepartment of Community and Family Medicine, Dartmouth Medical School, Dartmouth College
  • , Leila A. MottAffiliated withDepartment of Community and Family Medicine, Dartmouth Medical School, Dartmouth College
  • , Debra SilvermanAffiliated withDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
  • , Margaret KaragasAffiliated withDepartment of Community and Family Medicine, Dartmouth Medical School, Dartmouth College

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Abstract

Objective: To identify occupations with excess bladder cancer risk in New Hampshire, where bladder cancer mortality rates have been elevated for decades.

Methods: Lifetime occupational histories were obtained from interviews with 424 cases and 645 controls in a population-based case-control study.Unconditional logistic regression models were used to estimate odds ratios (Ors) and 95% confidence intervals (CI) for each occupation, adjusted for age and smoking. Analyses by duration of employment were carried out and interactions with smoking were examined.

Results: Male tractor-trailer truck drivers had an elevated risk for bladder cancer (OR = 2.4, CI = 1.4-4.1), with a significant positive trend in risk with increasing duration of employment (P trend= 0.0003). Male metal/plastic processing machine operators also had a significant excess (OR = 4.9, CI = 1.6-15.1), attributable mainly to molding/casting machine operators (OR = 16.6, CI = 2.1-131). Elevated risk was also observed for male fabricators, assemblers, and hand workers (OR = 1.8, CI = 1.0-3.4). Women in certain sales occupations (sales clerks, counter clerks, and cashiers) had a significant excess risk (OR = 2.2, CI = 1.3-3.9) and a significant trend with duration of employment (P trend= 0.016), as did female health service workers (OR = 4.1, CI = 1.6-10.7; P trend= 0.014). There was a positive interaction between smoking and employment as a health service worker (p= 0.036).

Conclusions: These findings are generally consistent with previous studies. Elevated risks for male molding/casting machine operators, female salesworkers, and female health service workers, especially those with a history of smoking, require further investigation.

bladder cancer occupation case-control study epidemiology